The Library

CEPHEUS Trial: Daratumumab-VRd Quadruplet Sets New Standard in Transplant-Ineligible Myeloma Nature medicine 2025 Landmark-class BENEFIT Trial: Isatuximab-VRd Quadruplet Doubles MRD Negativity in Transplant-Ineligible Myeloma Nature medicine 2024 Landmark-class DESTINY-Breast03 Long-Term Data Confirm T-DXd Superiority Over T-DM1 in HER2-Positive Breast Cancer Nature medicine 2024 Landmark-class AI-Based Digital Pathology Predicts Immunotherapy Response in Hepatocellular Carcinoma The Lancet. Oncology 2023 Landmark-class NCI-MATCH Trial: Lessons from the Largest Tumour-Agnostic Precision Oncology Study Nature medicine 2023 Landmark-class CPIC Guideline Expands Pharmacogenomic Recommendations for Serotonin Reuptake Inhibitor Antidepressants Clinical pharmacology and therapeutics 2023 Landmark-class Revumenib in KMT2A-Rearranged Leukaemia: MRD Clearance Validates Menin Inhibition Nature 2023 Landmark-class Tucatinib Extends Survival by 9 Months in HER2-Positive Breast Cancer Brain Metastases JAMA oncology 2023 Landmark-class DESTINY-Breast03: HER2 Testing Underpins Landmark ADC Trial Results Lancet (London, England) 2022 Landmark-class Cross-Ancestry Stroke GWAS Identifies 89 Risk Loci and Highlights Drug Targets Including F11 and PROC Nature 2022 Landmark-class DPYD Genotyping Before Fluoropyrimidine Chemotherapy: Clinical Evidence Supports Upfront Testing Clinical pharmacology and therapeutics 2022 Landmark-class Expanded NGS Biomarker Panel Identifies PI3K/AKT/PTEN-Altered Breast Cancers That Benefit from AKT Inhibition The Lancet. Oncology 2022 Landmark-class BRIDGES Study Maps Tumor Pathology Across Nine Breast Cancer Susceptibility Genes JAMA oncology 2022 Landmark-class CPIC Guideline for SLCO1B1, ABCG2, and CYP2C9 Genotypes Links Pharmacogenomics to Statin Safety Clinical pharmacology and therapeutics 2022 Landmark-class CPIC 2022 Update: CYP2C19 Genotype Now Drives Broader Antiplatelet Therapy Recommendations for Clopidogrel Clinical pharmacology and therapeutics 2022 Landmark-class Preimplantation Genetic Testing for Aneuploidy Does Not Improve Cumulative IVF Live-Birth Rates The New England journal of medicine 2021 Landmark-class Ticagrelor Beats Clopidogrel in CYP2C19 Loss-of-Function Carriers After Minor Stroke The New England journal of medicine 2021 Landmark-class Afirma vs ThyroSeq for Indeterminate Thyroid Nodules: Randomized Head-to-Head Trial JAMA oncology 2021 Landmark-class Tazemetostat Shows Durable Responses in EZH2-Mutant Follicular Lymphoma The Lancet. Oncology 2020 Landmark-class First-in-Human Trial of CRISPR-Edited PD-1 Knockout T Cells in Lung Cancer Nature medicine 2020 Landmark-class TOPARP-B Validates Olaparib Activity in Prostate Cancer with DNA Repair Defects The Lancet. Oncology 2019 Landmark-class POPular Genetics Trial Validates CYP2C19-Guided Antiplatelet Selection After Primary PCI The New England journal of medicine 2019 Landmark-class PERCH Study Maps Pneumonia Aetiology in Children Using Multiplex PCR Across Seven Countries Lancet (London, England) 2019 Landmark-class Metagenomic NGS of Cerebrospinal Fluid Improves Diagnosis of Meningitis and Encephalitis The New England journal of medicine 2019 Landmark-class PAGE Study: Prenatal Exome Sequencing Identifies Genetic Diagnoses in 8.5% of Fetal Anomalies Lancet (London, England) 2019 Landmark-class CPIC Guideline: TPMT and NUDT15 Genotyping Essential for Safe Thiopurine Dosing Across Ancestries Clinical pharmacology and therapeutics 2019 Landmark-class DPYD Genotype-Guided Fluoropyrimidine Dosing Improves Safety in Cancer Patients The Lancet. Oncology 2018 Landmark-class NEJM Review: Next-Generation Sequencing for Diagnosing Suspected Genetic Disorders The New England journal of medicine 2018 Landmark-class TNT Trial: BRCA1/2 Mutation Status Predicts Carboplatin Response in Triple-Negative Breast Cancer Nature medicine 2018 Landmark-class CPIC Guideline Update: DPYD Genotyping Before Fluoropyrimidine Chemotherapy to Prevent Severe Toxicity Clinical pharmacology and therapeutics 2017 Landmark-class Seven Molecular Subgroups of Medulloblastoma Refine Risk Stratification Beyond Standard Four The Lancet. Oncology 2017 Landmark-class DNA Methylation Profiling Outperforms WHO Grading for Meningioma Prognosis The Lancet. Oncology 2017 Landmark-class Genomic Loss of Heterozygosity by NGS Predicts PARP Inhibitor Response in Ovarian Cancer The Lancet. Oncology 2016 Landmark-class 2016 WHO Classification of Myeloid Neoplasms and Acute Leukemia: Key Revisions Blood 2016 Landmark-class HPV 16/18 Genotyping by Real-Time PCR Provides Clear Risk Stratification in Women with Normal Cytology Journal of clinical microbiology 2026 Landmark-class Multiplex Droplet Digital PCR Covers 10 NPM1 Mutations for AML Measurable Residual Disease Clinical chemistry 2026 Landmark-class Oral PCSK9 Inhibitor Enlicitide Slashes LDL-C by 58% in Familial Hypercholesterolaemia JAMA 2026 Landmark-class Multiplex Serology Assay Distinguishes Mpox Infection from Vaccinia Vaccination Using Ortholog Ratios Journal of clinical microbiology 2025 Landmark-class Dual-Target Measles PCR on Panther Fusion Differentiates Wild-Type from Vaccine Strains Amid US Outbreak Journal of clinical microbiology 2025 Landmark-class Whole-Genome Sequencing for AMR Surveillance: Methodologies, Validation, and Standardization Challenges Clinical microbiology reviews 2025 Landmark-class Expert Consensus: Routine NGS Not Warranted in All Sarcoma Patients, Expert Centers Essential JAMA oncology 2025 Landmark-class Machine Learning on MALDI-TOF Spectra Predicts Antimicrobial Resistance but Requires Local Retraining Journal of clinical microbiology 2025 Landmark-class Lung Cancer in Never-Smokers: NGS-Driven Genomic Profiling Guides Targeted Therapy JAMA 2025 Landmark-class Cefazolin Non-Inferior to Cloxacillin for MSSA Bacteraemia with Better Tolerability Lancet (London, England) 2025 Landmark-class Nordic Consensus Recommendations for Clinical Bioinformatics in Whole-Genome Sequencing Diagnostics Genome medicine 2025 Landmark-class DNA Methylation Markers ZNF582 and ASCL1 Predict Progression to Anal Cancer in High-Risk Patients EBioMedicine 2025 Landmark-class Revumenib Shows Meaningful Responses in NPM1-Mutated Relapsed/Refractory AML Blood 2025 Landmark-class Cancer of Unknown Primary: Molecular Profiling Transforms a Diagnostic Dead End Nature reviews. Clinical oncology 2025 Landmark-class Personalised Cancer Vaccines: NGS-Guided Neoantigen Targeting Enters Pivotal Trials Cancer discovery 2025 Landmark-class Mast Cell Heterogeneity Predicts Anti-PD-1 Response in Triple-Negative Breast Cancer Nature medicine 2025 Landmark-class Blood-Based Biomarkers for Neurological Disorders: From Simoa to Clinical Implementation Annals of laboratory medicine 2025 Landmark-class Venetoclax-Decitabine Non-Inferior to Intensive Chemotherapy in Young AML Patients Blood 2025 Landmark-class Noninvasive Prenatal Testing for Red Blood Cell and Platelet Antigens Enters Clinical Practice Blood 2025 Landmark-class Broad 324-Gene Panel Identifies More Matched Therapies but No Outcome Gain in Advanced Cancers Nature medicine 2025 Landmark-class Molecular Testing Now Indispensable for WHO Classification of CNS Tumors JAMA oncology 2025 Landmark-class Largest Bipolar Disorder GWAS Identifies 298 Risk Loci and Implicates GABAergic Interneurons Nature 2025 Landmark-class pi-HuB: International Initiative Maps the Complete Human Proteome for Precision Medicine Nature 2024 Landmark-class DeepGEM: Deep Learning Predicts Gene Mutations from Routine Histology Slides in Lung Cancer The Lancet. Oncology 2024 Landmark-class Synthetic Lethality: From PARP Inhibitors to a New Generation of Targeted Cancer Therapies Nature reviews. Clinical oncology 2024 Landmark-class Triple Epigenetic-Immunotherapy Overcomes Anti-PD-1 Resistance in Hodgkin Lymphoma Blood 2024 Landmark-class Obinutuzumab Outperforms Rituximab in Mantle Cell Lymphoma with Better MRD Clearance Blood 2024 Landmark-class EFLM Updates European Urinalysis Guideline with New Performance Standards Clinical chemistry and laboratory medicine 2024 Landmark-class Lancet Prostate Cancer Commission: Projected Case Surge Demands Diagnostic Capacity Scale-Up Lancet (London, England) 2024 Landmark-class Triple Combination of Anti-PD-1, HDAC Inhibitor, and Anti-VEGF Active in MSS Colorectal Cancer Nature medicine 2024 Landmark-class Niacin Metabolites 2PY and 4PY Linked to Cardiovascular Disease Risk via Vascular Inflammation Nature medicine 2024 Landmark-class Preemptive Pharmacogenomic Testing Cuts Psychiatric Adverse Events and Costs in Landmark PREPARE Trial EBioMedicine 2024 Landmark-class Microbiome-Derived Metabolites Show Promise for Pancreatic Cancer Risk Assessment Clinical chemistry 2024 Landmark-class Cannabis Exposure in Pregnancy Linked to Placental Dysfunction by LC-MS/MS-Confirmed Urine Testing JAMA 2023 Landmark-class Dual HER2 Blockade with Pyrotinib-Trastuzumab-Docetaxel Doubles PFS in Metastatic Breast Cancer BMJ (Clinical research ed.) 2023 Landmark-class BIOFIRE Joint Infection Panel Detects 39 Targets in Synovial Fluid in About One Hour Journal of clinical microbiology 2023 Landmark-class Molecular Tumor Boards: Evolving Role in Precision Oncology and Biomarker Interpretation Nature reviews. Clinical oncology 2023 Landmark-class PharmVar Tutorial Standardises CYP2D6 Structural Variant Detection and Reporting Clinical pharmacology and therapeutics 2023 Landmark-class Primary Brain Tumours: Molecular Diagnostics Drive the WHO 2021 CNS Classification Lancet (London, England) 2023 Landmark-class NTRK Fusion Testing in Thyroid Carcinoma: Expert Consensus on a Diagnostic Algorithm JAMA oncology 2023 Landmark-class Simplexa Congenital CMV Direct PCR Achieves Near-Perfect Agreement for Newborn Screening in Saliva and Urine Journal of clinical microbiology 2023 Landmark-class Updated UK Guidelines for HER2 Assessment in Breast Cancer Journal of clinical pathology 2022 Landmark-class LC-MS/MS in Clinical Diagnostics: A Primer on Implementation and Quality Management Nature reviews. Methods primers 2022 Landmark-class Multi-Omics Machine Learning Classifies Endocrine Hypertension Subtypes with 92% Accuracy EBioMedicine 2022 Landmark-class CPIC Guideline: G6PD Genotyping to Classify Medication-Induced Haemolysis Risk Clinical pharmacology and therapeutics 2022 Landmark-class Pharmacogenomic Testing Reduces Drug-Gene Interactions in Depression but Shows Modest Remission Benefit JAMA 2022 Landmark-class AI Predicts Genetic Alterations from H&E Slides: Systematic Review of the Evidence The Journal of pathology 2022 Landmark-class NIH SAVE Programme Defines Framework for Real-Time SARS-CoV-2 Variant Risk Assessment Nature 2022 Landmark-class Cancer Proteogenomics Integrates Protein Data With Genomics to Reveal New Therapeutic Targets Nature reviews. Cancer 2022 Landmark-class Beyond the Exome: A Guide to Diagnosing Rare and Undiagnosed Diseases Genome medicine 2022 Landmark-class Meta-Analysis Confirms ADT Prolongation Improves Metastasis-Free Survival in Prostate Cancer Radiotherapy The Lancet. Oncology 2022 Landmark-class Candida auris Detection: From Sequencing to MALDI-TOF and Rapid Molecular Tests Journal of clinical microbiology 2022 Landmark-class Deep Learning in Oncology: From Digital Pathology to Multi-Omics Integration Genome medicine 2021 Landmark-class Carboplatin Improves Survival in High-Risk Group 3 Medulloblastoma JAMA oncology 2021 Landmark-class Bacterial Meningitis: Conjugate Vaccines Reduce Incidence but Diagnostic Challenges Persist Lancet (London, England) 2021 Landmark-class CPIC Guideline: MT-RNR1 Genotyping to Prevent Aminoglycoside-Induced Hearing Loss Clinical pharmacology and therapeutics 2021 Landmark-class IDH Mutations as a Therapeutic Target Across Multiple Cancer Types Nature reviews. Clinical oncology 2021 Landmark-class 67% of MSI-High RAS/BRAF Wild-Type Colorectal Cancers Harbor Targetable Kinase Fusions Detectable by IHC and FISH Human pathology 2021 Landmark-class NTRK Fusions Across Solid Tumours: Biology, Prevalence, and Testing Strategies Human pathology 2021 Landmark-class CPIC Opioid Guideline: CYP2D6 Genotyping Recommended for Codeine and Tramadol Prescribing Clinical pharmacology and therapeutics 2021 Landmark-class Best Practices for Variant Calling in Clinical Next-Generation Sequencing Genome medicine 2020 Landmark-class Advances in Molecular Diagnostics for Tuberculosis Detection and Drug Resistance Journal of clinical microbiology 2020 Landmark-class CPIC Guideline: CYP2C19 Genotype-Guided Proton Pump Inhibitor Dosing Clinical pharmacology and therapeutics 2020 Landmark-class TAILOR-PCI Trial: Genotype-Guided P2Y12 Inhibitor Selection Narrowly Misses Primary Endpoint JAMA 2020 Landmark-class Hereditary Diffuse Gastric Cancer: Updated CDH1 Genetic Testing Guidelines The Lancet. Oncology 2020 Landmark-class Genetics of MDS-to-Secondary AML Progression Mapped by Next-Generation Sequencing Blood 2020 Landmark-class CheckMate 143: Nivolumab Does Not Improve Survival Over Bevacizumab in Recurrent Glioblastoma JAMA oncology 2020 Landmark-class MET-Dependent Solid Tumours: Diagnostic Approaches and Targeted Therapy Landscape Nature reviews. Clinical oncology 2020 Landmark-class Stool-Based PCR Achieves 96% Sensitivity for Noninvasive H. pylori Detection and Clarithromycin Resistance Testing Journal of clinical microbiology 2020 Landmark-class Genomic Risk Stratification Could Transform Smoldering Myeloma Management JAMA oncology 2020 Landmark-class Albumin RNA In Situ Hybridization Distinguishes Intrahepatic Cholangiocarcinoma from Metastatic Adenocarcinoma Journal of clinical pathology 2019 Landmark-class Lancet Genomic Medicine Series: Pharmacogenomics for Individualizing Drug Therapy Lancet (London, England) 2019 Landmark-class Building the Evidence Base for Genomic Medicine in Routine Clinical Care Lancet (London, England) 2019 Landmark-class WINTHER Trial Shows Combined DNA and RNA Profiling Improves Precision Oncology Matching Nature medicine 2019 Landmark-class Proteogenomics Adds Clinical Value Beyond Genomics-Only Cancer Profiling Nature reviews. Clinical oncology 2019 Landmark-class Somatic and Germline Genomics Reshape Childhood ALL Classification and Risk Stratification Nature reviews. Clinical oncology 2019 Landmark-class Rapid Respiratory Virus PCR Cuts Hospital Stay by 21 Hours and Reduces Unnecessary Testing Journal of clinical microbiology 2019 Landmark-class Apolipoprotein Profiling by Mass Spectrometry Enables Precision Cardiovascular Risk Assessment Annals of clinical biochemistry 2019 Landmark-class The Microbiome as a Modulator of Cancer Therapy Response Nature medicine 2019 Landmark-class Molecular Markers of Regulated Necrosis Enable Pathological Detection of Targetable Cell Death Pathways The Journal of pathology 2019 Landmark-class Genomic Landscape of Myelodysplastic Syndromes: A Comprehensive Review Blood 2019 Landmark-class Pan-Trk Immunohistochemistry Is 97% Sensitive and 98% Specific for NTRK Fusions in Pediatric Mesenchymal Tumors The American journal of surgical pathology 2018 Landmark-class Molecular Rapid Diagnostics with Stewardship Are Cost-Effective for Bloodstream Infections Clinical microbiology reviews 2018 Landmark-class The Cancer Genome as Biomarker: DNA Repair Deficiency and PARP Inhibitor Response The Journal of pathology 2018 Landmark-class Real-Time PCR Assay for Candida auris Surveillance Cuts Detection Time from 14 Days to 4 Hours Journal of clinical microbiology 2018 Landmark-class Beyond BRCA Founders: Panel Sequencing Uncovers Additional Cancer Risk in Ashkenazi Jewish Women JAMA oncology 2017 Landmark-class Bevacizumab Plus Lomustine Fails to Improve Overall Survival in Recurrent Glioblastoma The New England journal of medicine 2017 Landmark-class Syndromic Multiplex Panels Reshape Clinical Microbiology Practice Clinical microbiology reviews 2017 Landmark-class CPIC Guideline Links CYP2C19 Genotype to Voriconazole Dosing Clinical pharmacology and therapeutics 2017 Landmark-class TP53 and SMAD4 Inactivation Are Late Events in Pancreatic Cancer Progression The Journal of pathology 2017 Landmark-class Molecular Genetics of Gliomas Drives New Classification and Therapy Paradigm Nature reviews. Clinical oncology 2016 Landmark-class Clinical NGS in Pediatric Oncology Yields Actionable Findings in Two-Thirds of High-Risk Cases Genome medicine 2016 Landmark-class Tumour Heterogeneity Reshapes Precision Treatment in Colorectal Cancer Nature reviews. Clinical oncology 2016 Landmark-class CYP2C19 Loss-of-Function Alleles Eliminate Clopidogrel-Aspirin Benefit After Minor Stroke JAMA 2016 Landmark-class NHS Implementation Study Shows NIPT for Down Syndrome Reduces Invasive Testing by Thousands Annually BMJ (Clinical research ed.) 2016 Landmark-class Newer Line Probe Assays Prove Non-Inferior for Rapid MDR-TB Detection Journal of clinical microbiology 2016 Landmark-class Systemic Amyloidosis: Advances in Mass Spectrometry Typing and Diagnostic Imaging Lancet (London, England) 2015 Landmark-class FDA Outlines Regulatory Path for Clinical Mass Spectrometry Devices Clinical chemistry 2015 Landmark-class Antimicrobial Resistance Mechanisms in M. tuberculosis: A Translational Framework Clinical microbiology reviews 2026 Significance 7/10 Three Key Practice Updates in Non-Hodgkin Lymphoma Classification for 2026 Human pathology 2025 Significance 7/10 Prediabetes Remission Without Weight Loss Prevents Type 2 Diabetes via Visceral Fat Redistribution Nature medicine 2025 Significance 7/10 Methylcobalamin Halves Severe Hand-Foot Syndrome During Capecitabine Therapy BMJ (Clinical research ed.) 2025 Significance 7/10 Senolytics Combined with Anti-PD-1 Therapy Show Promise in Head and Neck Cancer Nature medicine 2025 Significance 7/10 QIAstat-Dx GI Panel 2 Detects 17 Enteric Pathogens with Over 90% Agreement in Multicenter Trial Journal of clinical microbiology 2025 Significance 7/10 Laboratory Medicine Central to CKD-MBD Management: PTH, Vitamin D, and Bone Turnover Markers Reviewed Clinical chemistry and laboratory medicine 2025 Significance 7/10 Large UK Cohort Maps KRAS Mutation Landscape in Non-Small Cell Lung Cancer Journal of clinical pathology 2025 Significance 7/10 GWAS Identifies First Genetic Locus for Drug-Resistant Focal Epilepsy EBioMedicine 2025 Significance 7/10 Pharmacogenomic Testing Evolves From Targeted Genotyping Toward Sequencing-Based Approaches Annals of laboratory medicine 2025 Significance 7/10 Urine-Based HPV Testing by Real-Time PCR Achieves 82% Sensitivity in Meta-Analysis of 15 Studies Journal of clinical microbiology 2025 Significance 7/10 Exemestane Cross-Reacts with All Androstenedione Immunoassays, Causing Falsely Elevated Results Annals of laboratory medicine 2025 Significance 7/10 Metabolomic Biomarkers Show Promise for Breast Cancer Diagnosis and Prognosis Annals of laboratory medicine 2025 Significance 7/10 Molecular Profiling Defines High-Risk Mantle Cell Lymphoma and Guides Therapy Selection Blood 2025 Significance 7/10 Practical Guide for Implementing DPYD Genotyping in Fluoropyrimidine Prescribing Clinical pharmacology and therapeutics 2025 Significance 7/10 Managing Post-Immunotherapy Relapse in B-ALL: Antigen Escape and Lineage Switch Blood 2025 Significance 7/10 Philadelphia Chromosome-Like ALL: NGS-Guided Targeted Therapy Strategies Blood 2025 Significance 7/10 Plasma Proteomics Identifies Mortality-Associated Protein Signatures in Sepsis EBioMedicine 2024 Significance 7/10 Rethinking UTI Diagnostics: The Case for Rapid, Culture-Independent Testing Clinical microbiology reviews 2024 Significance 7/10 Mass Spectrometry Transforms Clinical Immunoglobulin Analysis and M-Protein Detection Clinical chemistry 2024 Significance 7/10 Hybridization Bait Capture: Target Enrichment Advances Public Health Microbiology Clinical microbiology reviews 2024 Significance 7/10 Multiplexed Tissue Imaging Poised to Transform Precision Oncology Workflows Cancer discovery 2024 Significance 7/10 Molecular Diagnostics in CSF: Comprehensive Review of PCR Methods for CNS Infections Clinical microbiology reviews 2024 Significance 7/10 Capivasertib-Fulvestrant Maintains Quality of Life While Improving PFS in HR-Positive Breast Cancer The Lancet. Oncology 2024 Significance 7/10 Updated Guidance for Processing CF Respiratory Samples in the CFTR Modulator Era Clinical microbiology reviews 2024 Significance 7/10 Antiviral Resistance Testing in 2024: Shifting From Phenotypic to Genotypic Methods Journal of clinical microbiology 2024 Significance 7/10 Small-Cell Lung Cancer: Molecular Subtypes Open New Diagnostic and Therapeutic Windows Nature reviews. Clinical oncology 2024 Significance 7/10 CPIC Guideline: CYP2D6 Genotyping for Metoprolol Dose Adjustment Clinical pharmacology and therapeutics 2024 Significance 7/10 Computational Framework Proposed to Bridge RNA-Seq Signatures into PCR-Based Clinical Diagnostics EBioMedicine 2024 Significance 7/10 CPIC Finds Insufficient Evidence to Change Methadone Dosing Based on CYP2B6 Genotype Clinical pharmacology and therapeutics 2024 Significance 7/10 First-in-Human KAT6A/B Inhibitor Shows Durable Activity in ER-Positive Breast Cancer Nature medicine 2024 Significance 7/10 Laboratory Diagnostics for Endocrine Hypertension: From Current Biomarkers to Omics Clinical chemistry 2024 Significance 7/10 Validated Candida auris PCR Screening Assay Cuts Turnaround from Days to Hours Journal of clinical microbiology 2024 Significance 7/10 Automated NeuMoDx Mpox Assay Differentiates Clade I from Clade II with 99% Sensitivity Journal of clinical microbiology 2024 Significance 7/10 Microbiologic Diagnosis of Implant-Associated Infections: From Culture to NGS Clinical microbiology reviews 2024 Significance 7/10 Validating Biological Age Biomarkers: From Epigenetic Clocks to Multi-Omics Predictors Nature medicine 2024 Significance 7/10 Urine Albumin Measurement Standardization Critical for CKD Diagnosis Clinical chemistry 2024 Significance 7/10 NeoPACT: Anthracycline-Free Chemoimmunotherapy Shows Promise in Triple-Negative Breast Cancer JAMA oncology 2024 Significance 7/10 EGFR and MET Expression as Predictive Biomarkers for Amivantamab-Lazertinib in Osimertinib-Resistant NSCLC Nature medicine 2023 Significance 7/10 QIAstat-Dx Meningitis/Encephalitis Panel Matches BioFire FilmArray in Multicenter Evaluation Journal of clinical microbiology 2023 Significance 7/10 Direct-from-Blood Pathogen Detection: Molecular Technologies Challenge the Blood Culture Paradigm Journal of clinical microbiology 2023 Significance 7/10 Metagenomic Sequencing for Agnostic Viral Pathogen Detection: Promise and Barriers to Clinical Adoption Clinical microbiology reviews 2023 Significance 7/10 Parathyroid Hormone Measurement Evolves from Immunoassay to LC-MS/MS Clinical chemistry and laboratory medicine 2023 Significance 7/10 Cepheid Xpert GBS LB XC Test Validated in Multicenter Study for Prenatal GBS Screening Journal of clinical microbiology 2022 Significance 7/10 Lancet Seminar Reviews Precision Medicine Opportunities in Type 2 Diabetes Including Pharmacogenomics Lancet (London, England) 2022 Significance 7/10 Systematic Review Finds Most Pharmacogenomic Tests Are Cost-Effective Clinical pharmacology and therapeutics 2022 Significance 7/10 LC-MS/MS Operations Guide Covers Validation, QA, and Troubleshooting for Clinical Labs Annals of laboratory medicine 2022 Significance 7/10 Systematic Review Establishes Best Practices for LC-MS/MS Calibration in Clinical Labs Annals of laboratory medicine 2022 Significance 7/10 MSI/dMMR Testing in Pancreatic and Ampullary Carcinomas: Prevalence, Histotype Correlations, and Immunotherapy Implications Human pathology 2022 Significance 7/10 Radiotheranostics Enter Mainstream Oncology: A Clinical Pharmacology Primer Clinical pharmacology and therapeutics 2022 Significance 7/10 Acuitas AMR Gene Panel Accurately Detects 28 Resistance Markers in Cultured Bacterial Isolates Journal of clinical microbiology 2022 Significance 7/10 Digital PCR for SARS-CoV-2: Lessons for Future Pandemic Diagnostics Clinical microbiology reviews 2022 Significance 7/10 Comprehensive Guide to LC-MS/MS Method Development for Clinical Diagnostic Assays Annals of laboratory medicine 2022 Significance 7/10 Genetic and Epigenetic Landscape of Cutaneous T-Cell Lymphoma Mapped by NGS Blood 2022 Significance 7/10 COVID-19 Pandemic Innovations Fuel Next Generation of Infectious Disease Diagnostics Clinical biochemistry 2022 Significance 7/10 Rapid Antimicrobial Susceptibility Testing: Where Technology Stands and What Is Still Needed Clinical chemistry 2021 Significance 7/10 Inflammation Downregulates Drug-Metabolising Enzymes: Implications for Therapeutic Drug Monitoring Clinical pharmacology and therapeutics 2021 Significance 7/10 Pharmacogenetics of Antipsychotics: From CYP2D6 Dosing to Tardive Dyskinesia Risk Genes Clinical pharmacology and therapeutics 2021 Significance 7/10 Can Lab Tests Predict SARS-CoV-2 Infectivity? A Review of PCR, Antigen, and Subgenomic RNA Approaches Journal of clinical microbiology 2021 Significance 7/10 Race-Conscious Pharmacogenomics: Ancestry-Specific Variants and Equity in Drug Response Clinical pharmacology and therapeutics 2021 Significance 7/10 Immunopharmacogenomics: Mechanisms Behind HLA-Linked Drug Hypersensitivity Reactions Clinical pharmacology and therapeutics 2021 Significance 7/10 Pharmacogenetics Implementation Demands Broader Evidence Beyond RCTs Clinical pharmacology and therapeutics 2021 Significance 7/10 MRI Radiomics Plus Machine Learning Predicts Axillary Lymph Node Status in Breast Cancer EBioMedicine 2021 Significance 7/10 qPCR Kit Outperforms Microscopy for Early Detection of Congenital Chagas Disease EBioMedicine 2021 Significance 7/10 Computational Tools for Interpreting Rare Pharmacogenomic Variants from NGS Data Clinical pharmacology and therapeutics 2021 Significance 7/10 Rare VWF Gene Variants Predict von Willebrand Factor Antigen Levels Beyond Known Pathogenic Mutations Blood 2021 Significance 7/10 PERMED-01 Trial: Extensive Molecular Profiling Finds Actionable Targets in 71% of Advanced Cancers Genome medicine 2021 Significance 7/10 SARS-CoV-2 Detection Technologies: From PCR to Point-of-Care Biosensors Clinical microbiology reviews 2021 Significance 7/10 Epigenetic Combination Therapy Highly Active in T-Cell Lymphoma, NGS Identifies Mutation-Response Correlation Blood 2021 Significance 7/10 ALK and ROS1 Rearrangement Testing in NSCLC: IHC, FISH, and the Path to NGS Journal of clinical pathology 2021 Significance 7/10 Multi-Omics Pipelines Transform Diagnosis of Mitochondrial Disease The Journal of pathology 2021 Significance 7/10 Single-Cell Meta-Analysis Maps SARS-CoV-2 Entry Gene Expression Across Tissues and Demographics Nature medicine 2021 Significance 7/10 Unyvero BAL Panel Identifies Pneumonia Pathogens and Resistance Markers in 4.5 Hours Journal of clinical microbiology 2021 Significance 7/10 Cancer Epigenomics: Proper Controls and the Road to Clinical Translation Genome medicine 2021 Significance 7/10 Glioma Intratumoral Heterogeneity Challenges Molecular Diagnostics and Targeted Therapy Cancer discovery 2021 Significance 7/10 Clinical Metagenomic Sequencing for Pathogen Detection: When to Test and How to Interpret Clinical chemistry 2020 Significance 7/10 Largest Genomic Study of Low-Grade Serous Ovarian Carcinoma Identifies Actionable Targets in 90% of Cases The Journal of pathology 2020 Significance 7/10 16S rRNA Gene Sequencing for Bacterial Identification: Performance, Limits, and the Road to NGS Clinical microbiology reviews 2020 Significance 7/10 Xpert Carba-R Detects Carbapenemase Genes Directly from Sputum in Under 2 Hours Journal of clinical microbiology 2020 Significance 7/10 Sarcoma Epigenomics: Chromatin Pathway Alterations as Diagnostic and Therapeutic Targets Nature reviews. Cancer 2020 Significance 7/10 When to Order NGS in Oncology: A Practical Guide to Precision Medicine in Clinical Practice EClinicalMedicine 2020 Significance 7/10 Mass Spectrometry Outperforms Immunoassays for Cortisol in Cushing's Syndrome Screening Annals of laboratory medicine 2020 Significance 7/10 MALDI Mass Spectrometry: From Principles to Expanding Clinical Applications Clinical chemistry and laboratory medicine 2020 Significance 7/10 New Diagnostics for Invasive Fungal Infections: From Antigen Testing to Molecular Assays and VOC Detection Journal of clinical microbiology 2020 Significance 7/10 Proteomic Mass Spectrometry Expands Its Role Across Pathology and Laboratory Medicine Clinical biochemistry 2020 Significance 7/10 CPIC Guideline: CYP2C9 Genotyping for Safer NSAID Prescribing Clinical pharmacology and therapeutics 2020 Significance 7/10 BD Phoenix CPO Detect Accurately Identifies and Classifies Carbapenemases During Routine Susceptibility Testing Journal of clinical microbiology 2020 Significance 7/10 Molecular Diagnostics and Targeted Therapy Transform Management of Advanced Systemic Mastocytosis Blood 2020 Significance 7/10 ePlex Blood Culture ID Gram-Positive Panel Identifies 20 Pathogens and 4 Resistance Genes with High Accuracy Journal of clinical microbiology 2020 Significance 7/10 Mass Spectrometry Advances as the Gold Standard for Sex Hormone Measurement Clinical biochemistry 2020 Significance 7/10 LC-MS/MS Matures into Routine Clinical Diagnostics After a Decade of Growth Clinical biochemistry 2020 Significance 7/10 Lab Consolidation Enables AI-Driven Genomics and Transformative Diagnostic Platforms Clinical microbiology reviews 2020 Significance 7/10 Rapid Immunochromatographic Test Detects and Serogroups N. meningitidis from CSF in Under 15 Minutes Journal of clinical microbiology 2020 Significance 7/10 Digital PCR in Clinical Microbiology: Advantages, Limitations, and Practical Considerations Clinical chemistry 2020 Significance 7/10 Policy Challenges in Genomic Medicine: Reimbursement, FDA Oversight, and Gene Patent Threats Clinical chemistry 2020 Significance 7/10 Non-Driver Mutations in TP53 and Splicing Genes Predict Disease Transformation in Hydroxycarbamide-Resistant Essential Thrombocythemia Blood 2019 Significance 7/10 Clinical Mass Spectrometry Expands Across Pathology Disciplines Journal of clinical pathology 2019 Significance 7/10 Molecular Classification of CNS Tumors: Recurrent Genetic Alterations Since WHO 2016 Human pathology 2019 Significance 7/10 First US Surveillance Finds 7.5% Macrolide-Resistant Mycoplasma pneumoniae with Regional Variation Journal of clinical microbiology 2019 Significance 7/10 Novel PCR Assay Simultaneously Detects M. genitalium and Fluoroquinolone Resistance Journal of clinical microbiology 2019 Significance 7/10 8-Aminoquinoline Therapy for Latent Malaria: G6PD Testing Remains the Critical Bottleneck Clinical microbiology reviews 2019 Significance 7/10 MALDI Imaging Mass Spectrometry Poised to Complement IHC in Pathology Workflows Journal of clinical pathology 2019 Significance 7/10 International Consensus Criteria Standardise T-PLL Diagnosis and Response Assessment Blood 2019 Significance 7/10 Mass Spectrometry Serum Disaccharide Assay Shows Promise as Panfungal Diagnostic Across Six European Centers Journal of clinical microbiology 2019 Significance 7/10 Multiplex PCR Tracks Rapid Emergence of Fluoroquinolone-Resistant E. coli ST1193 Across the US Journal of clinical microbiology 2019 Significance 7/10 Aberrant Glycosylation as a Source of Cancer Biomarkers: Analytical Advances and Clinical Potential Clinical chemistry and laboratory medicine 2019 Significance 7/10 Single-Cell Genomics: From Research Tool to Clinical Laboratory Reality Clinical chemistry 2019 Significance 7/10 Framework for Developing Anti-Metastatic Agents: From Biology to Clinical Strategy Nature reviews. Clinical oncology 2019 Significance 7/10 TP53 Mutation Screening in CLL: NGS Detects Clinically Relevant Subclonal Mutations Missed by Sanger Journal of clinical pathology 2019 Significance 7/10 Current Landscape of MDS Treatment: From Hypomethylating Agents to Novel Targets Blood 2019 Significance 7/10 Fusion Sarcomas: Diagnostic Markers and Detection Methods for Newly Defined Entities Human pathology 2019 Significance 7/10 Personalized Neoantigen Vaccine Generates Intratumoral T Cell Responses in Glioblastoma Nature 2018 Significance 7/10 Phenotypic Assays for Carbapenemase Detection: A Practical Laboratory Review Journal of clinical microbiology 2018 Significance 7/10 Fentanyl Analog Detection: Analytical Challenges in the Synthetic Opioid Epidemic Clinical chemistry 2018 Significance 7/10 Laboratory Testing and Monitoring of Direct Oral Anticoagulants: Current State and Debate Blood 2018 Significance 7/10 FilmArray Meningitis Panel Detects Enterovirus in 25% of Young Infants Evaluated for CNS Infection Journal of clinical microbiology 2018 Significance 7/10 Pathogenesis of T-Cell Lymphomas Revealed by NGS and Gene Expression Profiling Blood 2018 Significance 7/10 Whole-Exome Sequencing Uncovers Diverse Genetic Mechanisms Beyond Familial HLH Genes in Pediatric Hemophagocytic Lymphohistiocytosis Blood 2018 Significance 7/10 European DPWG Guidelines Advance Pharmacogenomic Implementation Across the Continent Clinical pharmacology and therapeutics 2018 Significance 7/10 BCOR Internal Tandem Duplication Defines a New Subtype of High-Grade Uterine Sarcoma The American journal of surgical pathology 2018 Significance 7/10 Alere i Molecular Test Outperforms BD Veritor Antigen Assay for Rapid Strep A Detection Journal of clinical microbiology 2018 Significance 7/10 Proteomic Methods Unlock Tumour Heterogeneity Analysis in Archival FFPE Tissues The Journal of pathology 2018 Significance 7/10 DeepMelt Assay Detects 0.01% Isoniazid-Resistant TB Mutants Through Selective Wild-Type Clamping Journal of clinical microbiology 2018 Significance 7/10 Combined BAL Fractions Essential for Optimal Aspergillus and Mucorales PCR Sensitivity Journal of clinical microbiology 2018 Significance 7/10 Multiplex PCR Identifies Meningitis Pathogens in Culture-Negative CSF Within Hours Journal of clinical microbiology 2018 Significance 7/10 95-Gene Expression Classifier Identifies Primary Tumor Origin in Metastatic Cancers with 84% Accuracy Journal of clinical pathology 2017 Significance 7/10 Dried Blood Spots Cover Over 2,000 Analytes Across All Major Analytical Platforms Clinical chemistry 2017 Significance 7/10 De Novo Mutations in Neurodevelopmental Disorders: Patterns, Databases, and Clinical Impact Genome medicine 2017 Significance 7/10 CARD11 Mutations Predict Ibrutinib Resistance in Relapsed Follicular Lymphoma Blood 2017 Significance 7/10 ROS1 Fusions in NSCLC: Detection Methods for the Clinical Laboratory Journal of clinical pathology 2017 Significance 7/10 Precision Medicine in Biliary Tract Cancers: Actionable Mutations and Emerging Targeted Therapies Cancer discovery 2017 Significance 7/10 Multiplex PCR Simultaneously Identifies N. gonorrhoeae and Predicts Ciprofloxacin Susceptibility Journal of clinical microbiology 2017 Significance 7/10 Daratumumab Plus Pomalidomide-Dexamethasone: Deep MRD Responses in Heavily Treated Myeloma Blood 2017 Significance 7/10 Genome-Wide vs. Panel vs. Single-Gene Testing: Choosing the Right Approach in Hematologic Malignancies Blood 2017 Significance 7/10 Preanalytical Best Practices for LC-MS Analysis of Blood Specimens Clinical biochemistry 2017 Significance 7/10 TaqMan Array Card Tests CSF for 21 Meningitis Pathogens in a Single 2.5-Hour Run Journal of clinical microbiology 2017 Significance 7/10 CPIC Updates Warfarin Dosing Guideline with CYP4F2 and Ancestry-Specific Recommendations Clinical pharmacology and therapeutics 2017 Significance 7/10 Digital PCR Enters the Clinical Microbiology Lab: Advantages Over qPCR Journal of clinical microbiology 2017 Significance 7/10 Idylla Automated PCR Platform Shows 100% Concordance with NGS for Colorectal Cancer Mutation Testing Journal of clinical pathology 2017 Significance 7/10 NGS and GWAS Reshape the Genetic Landscape of Dilated Cardiomyopathy and Heart Failure Genome medicine 2017 Significance 7/10 CPIC Updates Guideline for CYP2D6/CYP2C19-Guided Tricyclic Antidepressant Dosing Clinical pharmacology and therapeutics 2017 Significance 7/10 Portrait Staph ID/R Panel Achieves 99.4% Agreement for Rapid Staphylococcus Identification from Blood Cultures Journal of clinical microbiology 2017 Significance 7/10 Genomic Evolution of Ductal Carcinoma In Situ: Clonal Models of Invasion The Journal of pathology 2016 Significance 7/10 Chronic Kidney Disease: Laboratory Diagnostics from GFR Estimation to Novel Biomarkers Lancet (London, England) 2016 Significance 7/10 Decoding Cancer Evolution Through Genomic Analysis of Tumour Clonal Dynamics The Journal of pathology 2016 Significance 7/10 MALDI-TOF MS Revolutionises Identification of Clinically Important Molds Journal of clinical microbiology 2016 Significance 7/10 NGS Drives Gene Discovery in Mitochondrial Disease: Over 250 Genes Now Implicated The Journal of pathology 2016 Significance 7/10 Digital PCR Outperforms qPCR for Viral Load Quantification Without Calibration Curves Clinical chemistry and laboratory medicine 2016 Significance 7/10 Deutetrabenazine RCT Shows Significant Chorea Reduction in Huntington Disease JAMA 2016 Significance 7/10 Point-of-Care Microbiology Labs: Bringing Rapid PCR Diagnostics Closer to Patients Clinical microbiology reviews 2016 Significance 7/10 Acute Bacterial Meningitis in Adults: Multiplex PCR and Novel Platforms Accelerate Diagnosis Lancet (London, England) 2016 Significance 7/10 Measuring Monoclonal Proteins: From Electrophoresis Limitations to LC-MS/MS Precision Clinical chemistry and laboratory medicine 2016 Significance 7/10 Mass Spectrometry and Free Light Chain Assays Transform Monoclonal Gammopathy Detection Clinical chemistry and laboratory medicine 2016 Significance 7/10 LC-MS/MS in Therapeutic Drug Monitoring: Current Status and Future Directions Clinical biochemistry 2016 Significance 7/10 Lynch Syndrome Screening in Gynecologic Cancers: Current Algorithms and Future Directions The American journal of surgical pathology 2016 Significance 7/10 Detecting Intestinal Carriage of Carbapenemase Producers: Culture vs Molecular Methods Clinical microbiology reviews 2016 Significance 7/10 NGS-Guided Targeted Therapies Reshape the Treatment Landscape for Acute Myeloid Leukemia Blood 2015 Significance 7/10 MALDI-TOF MS Set to Expand Beyond Microbiology Into Broader Clinical Chemistry Clinical chemistry 2015 Significance 7/10 Ambient Ionization Mass Spectrometry for Real-Time Cancer Diagnosis and Surgical Margins Clinical chemistry 2015 Significance 7/10 Anyplex Multiplex PCR Validated for Rapid TB Detection and Isoniazid Resistance in Pulmonary and Extrapulmonary Specimens Journal of clinical microbiology 2015 Significance 7/10 IQ Consortium Reviews Human Mass Balance Study Designs Including Microtracer and AMS Approaches Clinical pharmacology and therapeutics 2026 Significance 6/10 Multicenter Validation of Clonit Toxoplasma PCR Kit Shows 94.7% Clinical Sensitivity Journal of clinical microbiology 2025 Significance 6/10 Twenty Years of Human Bocavirus: From Diagnostic Puzzle to Confirmed Respiratory Pathogen Clinical microbiology reviews 2025 Significance 6/10 Non-Diphtheriae Corynebacterium: An Underestimated Clinical Pathogen Requiring MALDI-TOF Identification Journal of clinical microbiology 2025 Significance 6/10 VMAT2 Inhibitors in Movement Disorders: Pharmacogenetics Shapes Personalised Dosing Lancet (London, England) 2025 Significance 6/10 AI and Molecular Biomarkers Drive Precision Diagnosis in Lupus Nephritis EBioMedicine 2025 Significance 6/10 Primary Renal Ewing Sarcoma: 24-Case Series Identifies Rare EWSR1::ETV4 Fusion The American journal of surgical pathology 2025 Significance 6/10 Novel Diagnostics for Urinary Tract Infections: Molecular Methods and NGS Enter the Lab Journal of clinical microbiology 2025 Significance 6/10 Angioimmunoblastic T-Cell Lymphoma: Diagnostic Pathology and Molecular Landscape Human pathology 2024 Significance 6/10 Cystatin C as a GFR Biomarker: Adoption Challenges and Standardisation Gaps Clinical biochemistry 2024 Significance 6/10 Emerging Technologies in Paediatric Laboratory Medicine: From Microassays to Machine Learning Clinical chemistry and laboratory medicine 2024 Significance 6/10 Laboratory Testing for Prenatal Substance Exposure: Methods, Matrices, and Interpretation Pitfalls Clinical chemistry 2024 Significance 6/10 Micronuclei as Cancer Biomarkers: From Chromosomal Instability to Clinical Application Cancer discovery 2024 Significance 6/10 AUC-Guided Vancomycin TDM With Bayesian Forecasting Recommended for All Paediatric Populations Clinical biochemistry 2024 Significance 6/10 AI Models Show Strong Performance Across Urinalysis Applications Clinical chemistry 2023 Significance 6/10 Immunoassay vs LC-MS for Androgen Measurement: Pitfalls and Clinical Guidance Clinical chemistry 2023 Significance 6/10 Systemic Lupus Erythematosus: Autoantibody Panels and Molecular Diagnostics in SLE BMJ (Clinical research ed.) 2023 Significance 6/10 Co-Occurring Genomic Alterations in Sarcomas: Secondary Hits That Drive Sarcomagenesis The Journal of pathology 2023 Significance 6/10 Genetics of Human Infertility: Expanding Demand for Reproductive Genomic Testing Science (New York, N.Y.) 2023 Significance 6/10 Molecular Approaches Transform Discrimination of Multiple Primary vs Metastatic Lung Cancers EBioMedicine 2023 Significance 6/10 Practical Guide to Investigating Lead, Mercury, and Arsenic Poisoning in General Practice Journal of clinical pathology 2022 Significance 6/10 Updated Review: Nocardia Identification Transformed by MALDI-TOF and Whole Genome Sequencing Clinical microbiology reviews 2022 Significance 6/10 Two Decades of Clinical Mass Spectrometry Progress: From Neonatal Screening to Protein Biomarkers Clinical chemistry and laboratory medicine 2022 Significance 6/10 HIV-1 Drug Resistance Testing From Proviral DNA: Methods, Dynamics, and Clinical Utility Clinical microbiology reviews 2022 Significance 6/10 Synthetic Norovirus RNA Reference Materials Enable Quality Control Across Commercial Detection Kits Annals of laboratory medicine 2022 Significance 6/10 Scoping Review Maps Current State of Pharmacogenomic Clinical Decision Support Clinical pharmacology and therapeutics 2022 Significance 6/10 PharmVar Standardises SLCO1B1 Star Allele Nomenclature for Statin Safety Testing Clinical pharmacology and therapeutics 2022 Significance 6/10 Hepatoid Tumors of the GI Tract: Immunohistochemical and Molecular Profiles for Differential Diagnosis Human pathology 2022 Significance 6/10 NGS Expands the Genetic Landscape of Inherited Thrombocytopenias to Over 40 Genes Blood 2022 Significance 6/10 Advances in HIV Diagnostics: From Rapid Tests to NGS for Ending the Epidemic Clinical biochemistry 2022 Significance 6/10 Molecular Testing Resolves High Diagnostic Discrepancy Rates in Endometrial Stromal Sarcoma Human pathology 2022 Significance 6/10 Simplexa VZV Direct Assay Detects Varicella-Zoster Virus Without Nucleic Acid Extraction Journal of clinical microbiology 2022 Significance 6/10 Laboratory Biomarkers for Multiple Sclerosis: From Oligoclonal Bands to Neurofilament Light Clinical biochemistry 2021 Significance 6/10 Variant Classification Challenges in Hereditary Hemochromatosis Diagnostics Clinical chemistry 2021 Significance 6/10 Treatment Landscape for Malignant Pleural Mesothelioma: Current Options and Future Directions The New England journal of medicine 2021 Significance 6/10 Cancer-Associated Fibroblasts: Emerging Biomarker and Therapeutic Target in the Tumour Microenvironment Nature reviews. Clinical oncology 2021 Significance 6/10 How-To Guide for Building Pharmacogenomic Clinical Decision Support Systems Clinical pharmacology and therapeutics 2021 Significance 6/10 Decade of Pharmacogenomic GWAS: Trends, Discoveries, and the Road to Biobank-Scale Studies Clinical pharmacology and therapeutics 2021 Significance 6/10 PharmVar Catalogues CYP2C9 Star Alleles Critical for Warfarin and NSAID Safety Clinical pharmacology and therapeutics 2021 Significance 6/10 Pharmacogenetic-Guided Antidepressant Prescribing: Clinical Reality and Implementation Barriers Clinical pharmacology and therapeutics 2021 Significance 6/10 Nanopore Sequencing for Tuberculosis: Promise and Gaps in Current Evidence Journal of clinical microbiology 2021 Significance 6/10 Abbott RealTime and Alinity m SARS-CoV-2 Assays Validated with Head-to-Head Platform Comparison Journal of clinical microbiology 2021 Significance 6/10 Burkitt Lymphoma in Adults: Genomic Landscape and Treatment Challenges Blood 2021 Significance 6/10 Ewing Sarcoma: Molecular Pathogenesis, Diagnosis, and Emerging Therapeutic Targets The New England journal of medicine 2021 Significance 6/10 PD-L1 Expression Predicts Avelumab Response in Relapsed NK/T-Cell Lymphoma Blood 2020 Significance 6/10 Culturing the Uncultured: New Strategies for Growing Human Microbiota in the Sequencing Era Clinical microbiology reviews 2020 Significance 6/10 Targeted NGS Reveals Distinctive Mutational Profile of Primary Cutaneous Follicle Center Lymphoma Human pathology 2020 Significance 6/10 Lung Microbiome Challenges Traditional Ventilator-Associated Pneumonia Paradigms EBioMedicine 2020 Significance 6/10 Congenital Dyserythropoietic Anemias: NGS Transforms Diagnosis of Rare Inherited Anemias Blood 2020 Significance 6/10 Sex and Gender Differences in Diagnostics: Implications for Laboratory Reference Ranges Lancet (London, England) 2020 Significance 6/10 HEARTBiT Blood-Based Gene Profiling Assay Validated for Heart Transplant Rejection Monitoring Clinical chemistry 2020 Significance 6/10 JCTLM Task Force Assesses Metrological Traceability Using Creatinine as a Model Measurand Clinical chemistry and laboratory medicine 2020 Significance 6/10 PharmVar GeneFocus: CYP2C19 Nomenclature Underpinning Clopidogrel and PPI Guidelines Clinical pharmacology and therapeutics 2020 Significance 6/10 Comprehensive Review of Cannabinoid Analysis Across Biological Matrices by LC-MS/MS Clinical chemistry 2020 Significance 6/10 Mass Spectrometry Imaging for Predicting Bone Fracture Healing and Cartilage Repair Outcomes Clinical chemistry and laboratory medicine 2020 Significance 6/10 In-House vs. Kit-Based LC-MS/MS Methods: A Practical Guide for Clinical Laboratories Clinical chemistry and laboratory medicine 2020 Significance 6/10 Revogene Strep A Molecular Assay Delivers 98% Sensitivity in Multicenter Evaluation Journal of clinical microbiology 2020 Significance 6/10 COVID-19 Diagnostics: Real-Time PCR and NGS Enable Early Pathogen Detection Clinical microbiology reviews 2020 Significance 6/10 Mass Spectrometry Reveals How Gut Microbial Metabolites Drive Disease Clinical chemistry and laboratory medicine 2020 Significance 6/10 Revogene C. difficile Test Demonstrates 85% Sensitivity for Toxin B Gene Detection in Multicenter Trial Journal of clinical microbiology 2020 Significance 6/10 PharmVar GeneFocus: CYP2D6 Star Allele Nomenclature for the Most-Tested Pharmacogene Clinical pharmacology and therapeutics 2019 Significance 6/10 16-Gene Panel Characterizes Mutational Landscape of Breast Fibroepithelial Lesions in International Cohort The Journal of pathology 2019 Significance 6/10 Metabolomics Enters Clinical Pharmacology: Biomarker Discovery to Drug Response Prediction Clinical pharmacology and therapeutics 2019 Significance 6/10 SR-BI P376L Variant Linked to Dysfunctional HDL and Increased Cardiovascular Risk Clinical biochemistry 2019 Significance 6/10 High-Dose Vitamin C Targets Redox Imbalance, Epigenetics, and Oxygen Sensing in Cancer Nature reviews. Cancer 2019 Significance 6/10 False Positives Plague Widely Used Dientamoeba fragilis PCR Assay Across Multiple Platforms Journal of clinical microbiology 2019 Significance 6/10 Multiplex RT-PCR Distinguishes Wild-Type Measles from Vaccine Strains in a Single Reaction Journal of clinical microbiology 2019 Significance 6/10 Multiplex PCR for Shigella flexneri Serotyping Validated Across Seven International Laboratories Journal of clinical microbiology 2019 Significance 6/10 NeuMoDx GBS Assay Matches CDC Culture Method with 96.9% Sensitivity for Antepartum Screening Journal of clinical microbiology 2019 Significance 6/10 Epilepsy Diagnostics: From EEG to Genomic Testing and Pharmacogenomics Lancet (London, England) 2019 Significance 6/10 Triplex PCR Algorithm Validated for Rapid Bordetella Species Identification in Pediatric Whooping Cough Journal of clinical microbiology 2019 Significance 6/10 Automated Urinalysis Advances: From Flow Cytometry to MALDI-TOF Pathogen ID Annals of laboratory medicine 2019 Significance 6/10 Immunogenomics of Glioblastoma: Molecular Subtyping Reveals Distinct Immune Evasion Mechanisms NPJ precision oncology 2018 Significance 6/10 Whole Exome Sequencing Reveals Wnt Pathway Mutations in Biliary Papillary Neoplasms The American journal of surgical pathology 2018 Significance 6/10 NGS Applications in Biodefense: Biosurveillance, Forensics, and Biothreat Diagnostics Clinical chemistry 2018 Significance 6/10 JAMA Review: Pharmacogenetics Not Yet Ready for Personalizing Alcohol Use Disorder Treatment JAMA 2018 Significance 6/10 Molecular Diagnosis of Bacterial Vaginosis: Objective Testing Beyond Microscopy Journal of clinical microbiology 2018 Significance 6/10 Luminex Aries GBS Assay Achieves 96% Sensitivity with Minimal Hands-On Time Journal of clinical microbiology 2018 Significance 6/10 Multi-Omics Approaches Open New Avenues for Alzheimer's Disease Biomarker Discovery Clinical biochemistry 2018 Significance 6/10 NGS Identifies Recurrent Targetable Mutations in Cervical Small Cell Neuroendocrine Carcinoma The American journal of surgical pathology 2018 Significance 6/10 Experimental Design, Randomisation, and Validation: Foundations for Reliable Biomarker Discovery Clinical chemistry 2018 Significance 6/10 QuantiFERON-CMV Assay Predicts Post-Transplant CMV Infection Risk in Heart Recipients Journal of clinical microbiology 2018 Significance 6/10 cobas Cdiff PCR Validated for Active Surveillance of Asymptomatic C. difficile Carriers Journal of clinical microbiology 2018 Significance 6/10 Pulmonary Arterial Hypertension: Biomarkers from BNP to Molecular Subtypes BMJ (Clinical research ed.) 2018 Significance 6/10 Preemptive Pharmacogenomic Testing Shows Clinical Benefit When Linked to EHR Decision Support Clinical pharmacology and therapeutics 2018 Significance 6/10 Cartridge-Based PCR Achieves 100% Sensitivity for Coccidioides in Lower Respiratory Specimens Journal of clinical microbiology 2018 Significance 6/10 Population Pharmacokinetics of Polymyxin B Characterised by LC-MS/MS Clinical pharmacology and therapeutics 2018 Significance 6/10 Neuropeptides as Biomarkers and Drug Targets in Obesity: From Bench to Bedside Clinical chemistry 2017 Significance 6/10 BD Max Extended Enteric Panel Validated for Yersinia, ETEC, Vibrio, and Plesiomonas Detection in Stool Journal of clinical microbiology 2017 Significance 6/10 Metaplasia as a Precursor to Dysplasia and Cancer: Mechanisms and Screening Implications Nature reviews. Cancer 2017 Significance 6/10 Hypothesis-Free Molecular Microbiology: The Case for a Universal Sequencing-Based Diagnostic Test Journal of clinical microbiology 2017 Significance 6/10 Genotyping Strategies for Medically Important Fungi: MLST, Microsatellites, and NGS Clinical microbiology reviews 2017 Significance 6/10 GBS Detection Modernised With MALDI-TOF, Molecular Assays, and Chromogenic Media Journal of clinical microbiology 2017 Significance 6/10 Quality Control Materials for Pharmacogenomic Testing: Current Sources and Future Needs Clinical chemistry and laboratory medicine 2017 Significance 6/10 Response-Tailored HCV Treatment Using On-Treatment PCR Monitoring Proves Non-Inferior to Fixed 12-Week Course EBioMedicine 2017 Significance 6/10 miRNA Assays for Clinical Diagnostics: Detection Technologies, Workflows, and Automation Clinical chemistry and laboratory medicine 2017 Significance 6/10 Biological Age Predictors: Epigenetic Clocks Lead the Multi-Omics Race EBioMedicine 2017 Significance 6/10 Cortisol Measurement Across Matrices: Immunoassay Limitations and the LC-MS/MS Advantage Annals of clinical biochemistry 2017 Significance 6/10 Toxoplasma ELITe MGB Commercial PCR Kit Shows 89% Sensitivity but Extraction Method Matters Journal of clinical microbiology 2017 Significance 6/10 LINE-1 Retrotransposon as an Emerging Cancer Biomarker: Methylation, RNA, and Protein Markers Clinical chemistry 2017 Significance 6/10 Roche HCV RNA Assays on cobas 6800/8800 Show Excellent Sensitivity and Cross-Platform Agreement Journal of clinical microbiology 2017 Significance 6/10 Ciliopathies Reclassified: From Clinical Syndromes to Functional Modules of the Cilium The Journal of pathology 2017 Significance 6/10 SYBR Green qPCR on Noninvasive Swabs Matches Biopsy Accuracy for Leishmaniasis Diagnosis Journal of clinical microbiology 2016 Significance 6/10 NGS Uncovers New Pathogenic Mechanisms in Tuberous Sclerosis Complex Tumours The Journal of pathology 2016 Significance 6/10 Pharmacogenomics of Cardiovascular Drugs: Statins, P2Y12 Inhibitors, and Anticoagulants Clinical chemistry 2016 Significance 6/10 BD Max Enteric Parasite PCR Panel Matches or Exceeds Microscopy for Giardia, Crypto, and Entamoeba Journal of clinical microbiology 2016 Significance 6/10 Persistent Diarrhoea: How Multiplex PCR Is Changing Diagnostic Workup JAMA 2016 Significance 6/10 Real-Time PCR with High-Resolution Melting Detects Gonorrhoea Resistance Markers in 90 Minutes Journal of clinical microbiology 2016 Significance 6/10 Dried Blood Spot Analysis by Mass Spectrometry for Therapeutic Drug Monitoring Clinical biochemistry 2016 Significance 6/10 Personalised Thrombosis Medicine: Genomics Has Not Yet Replaced Functional Coagulation Testing Blood 2016 Significance 6/10 Consolidating Antibiotic Resistance Gene Databases for Clinical Microbiology Journal of clinical microbiology 2016 Significance 6/10 Ion Mobility Spectrometry Emerges as Rapid Bedside Screening Tool for Clinical Labs Clinical chemistry 2015 Significance 6/10 Mass Spectrometry of Exhaled Breath Nonvolatiles: An Emerging Biomarker Source Clinical chemistry 2015 Significance 6/10 Mass Spectrometry as a Phenotypic Complement to Pharmacogenomics in Precision Medicine Clinical chemistry 2015 Significance 6/10 Mass Spectrometry Delivers Cost-Effective Solutions Across Expanding Clinical Applications Clinical chemistry 2015 Significance 6/10 Ambient Ionization Mass Spectrometry Targets Point-of-Care Diagnostics Clinical chemistry 2015 Significance 6/10 Single-Dose Lysergide (MM120) Shows Dose-Dependent Anxiety Reduction in GAD Trial JAMA 2025 Significance 5/10 Advancing Anaerobic Microbial Cultivation to Complement NGS-Based Microbiome Research Nature biotechnology 2025 Significance 5/10 PharmVar Defines 14 Novel CYP4F2 Star Alleles Affecting Warfarin and Vitamin K Metabolism Clinical pharmacology and therapeutics 2024 Significance 5/10 EWSR1::NFATC2 Round Cell Sarcoma: A Four-Case Series Supports Classification as a Distinct Entity Diagnostic pathology 2024 Significance 5/10 Phase III MDMA-Assisted Therapy Shows Significant PTSD Symptom Reduction Nature medicine 2023 Significance 5/10 Hypertriglyceridaemia: Genetic Diagnosis and the Role of NGS in Lipid Disorders Journal of clinical pathology 2022 Significance 5/10 PharmVar Updates CYP3A5 Nomenclature for Tacrolimus Dose Optimisation Clinical pharmacology and therapeutics 2022 Significance 5/10 Idiotype Vaccine Plus Adoptive T-Cell Transfer Shows Enhanced Immune Reconstitution in Myeloma Blood 2022 Significance 5/10 Sublingual Dexmedetomidine Rapidly Reduces Acute Agitation in Bipolar Disorder JAMA 2022 Significance 5/10 Mendelian Randomisation Links Kidney Damage to Brain Cortical Thinning EBioMedicine 2021 Significance 5/10 MDMA-Assisted Therapy for PTSD: Phase 3 Trial and Implications for Drug Testing Laboratories Nature medicine 2021 Significance 5/10 PharmVar Catalogues CYP2B6 Variation Impacting Efavirenz, Methadone, and Ketamine Clinical pharmacology and therapeutics 2021 Significance 5/10 Historical Controls in Clinical Trials: Promise and Pharmacogenomic Pitfalls Clinical pharmacology and therapeutics 2020 Significance 5/10 Favipiravir Pharmacokinetics and Drug Interaction Concerns for COVID-19 Trials Clinical pharmacology and therapeutics 2020 Significance 5/10 Real-Time PCR for Tuberculous Meningitis: High Specificity but Limited Sensitivity in CSF Clinical chemistry and laboratory medicine 2019 Significance 5/10 Best Practices for Reporting Pharmacogenomics Studies: A PharmGKB Perspective Clinical pharmacology and therapeutics 2019 Significance 5/10 Neuregulin-1 mRNA Levels Downregulated in Autism Spectrum Disorder and Linked to Executive Function Deficits EBioMedicine 2018 Significance 5/10 HIV-TB Coinfection in Children and Pregnant Women: Pharmacogenomic and Drug Interaction Challenges Clinical pharmacology and therapeutics 2018 Significance 5/10 Subpopulation Primer Strategy Achieves Exhaustive H5 Avian Influenza Detection by LAMP Journal of clinical microbiology 2018 Significance 5/10 Rickettsioses Diagnostics Evolve Beyond Serology With Molecular and MS-Based Methods Journal of clinical microbiology 2018 Significance 5/10 Genetic Counseling Faces New Complexity in the NGS Era Annals of laboratory medicine 2018 Significance 5/10 SMART Therapy Reduces Asthma Exacerbations: Systematic Review and Meta-Analysis JAMA 2018 Significance 5/10 Nocardia Identification Challenges: Taxonomy Complexity Demands Molecular Methods Journal of clinical microbiology 2017 Significance 5/10 NGS Reveals Recurrent MED12 Mutations in Breast Fibroadenomas, Aiding Phyllodes Tumor Distinction Journal of clinical pathology 2017 Significance 5/10 Biochemistry of the Menopause: Diagnostic Assays and Hormone Reference Intervals Annals of clinical biochemistry 2017 Significance 5/10 Measuring Vitamin K in Blood: HPLC and LC-MS/MS Methods Compared Clinical chemistry and laboratory medicine 2017 Significance 5/10 Novel Multiplex PCR Enables Rapid Screening for Multidrug-Resistant E. coli ST648 Journal of clinical microbiology 2017 Significance 5/10 BD Max Open System Validated for Multiplex Mycobacterial Detection Directly from Clinical Specimens Journal of clinical microbiology 2016 Significance 5/10 Home-Based Transcranial Direct Current Stimulation Shows Efficacy in Major Depression Trial Nature medicine 2024 Significance 4/10 NEJM Review: Neuroleptic Malignant Syndrome Diagnosis and Management The New England journal of medicine 2024 Significance 4/10 Network Meta-Analysis: High-Dose Psilocybin Outperforms Placebo for Depression, But Effect Is Small BMJ (Clinical research ed.) 2024 Significance 4/10 PharmVar GeneFocus: CYP2A6 Nomenclature for Nicotine Metabolism and Drug Interactions Clinical pharmacology and therapeutics 2024 Significance 4/10 Persistent Physical Symptoms: Biomarker Gaps in Somatic Symptom Disorders Lancet (London, England) 2024 Significance 4/10 Behcet's Syndrome: Diagnostic Challenges Without Pathognomonic Biomarkers Lancet (London, England) 2024 Significance 4/10 Schizophrenia: Neuroimaging and Biomarker Challenges in Psychiatric Diagnosis Lancet (London, England) 2022 Significance 4/10 Novel HK1 Variant Identified as Cause of Hereditary Hemolytic Anemia via Whole-Exome Sequencing Journal of clinical pathology 2020 Significance 4/10 First Reported Primary Adenocarcinoma of the Spermatic Cord with SMARCB1 Deficiency Diagnostic pathology 2024 Significance 3/10 First TP53-Mutant Low-Grade Papillary Schneiderian Carcinoma Documented Without DEK::AFF2 Fusion Diagnostic pathology 2023 Significance 3/10 Anxiety Disorders: The Search for Objective Diagnostic Biomarkers Lancet (London, England) 2021 Significance 3/10

MINDACT Trial: 70-Gene Signature Spares 46% of High-Clinical-Risk Breast Cancer Patients From Chemotherapy The New England journal of medicine 2016 Landmark-class SYSUCC-001 Ten-Year Update: Metronomic Capecitabine Benefits Triple-Negative Breast Cancer, FOXC1 Predicts Response The Lancet. Oncology 2025 Landmark-class ASAP trial: genetic risk, not remission status, predicts transplant outcomes in AML Blood 2025 Landmark-class Clinical Exome and Genome Sequencing Yields 39% Diagnostic Rate in 2,700 Adults Genome medicine 2025 Landmark-class New CORE Score Outperforms FIB-4 for Predicting 10-Year Cirrhosis Risk Using Routine Lab Tests BMJ (Clinical research ed.) 2025 Landmark-class Mutant KRAS ctDNA at 160 Copies/mL Predicts Survival in Pancreatic Cancer Clinical chemistry 2025 Landmark-class Review: Using ctDNA to Map Resistance Mechanisms to Targeted Therapy in NSCLC Nature reviews. Clinical oncology 2025 Landmark-class Polygenic Risk Scores Poised to Reshape Precision Medicine Across Diseases Clinical chemistry 2025 Landmark-class Oncolytic Virus Plus Nivolumab Achieves 42% Complete Response in Bladder Cancer, Guided by E2F and TMB Biomarkers Nature medicine 2024 Landmark-class Plasma Cell-Free DNA Sequencing Now Detects Antimicrobial Resistance Markers Directly from Blood Journal of clinical microbiology 2024 Landmark-class T-cell receptor therapy afami-cel achieves durable responses in MAGE-A4-positive sarcomas Lancet (London, England) 2024 Landmark-class Blood-Based Biomarkers Are Transforming Alzheimer's Disease Diagnostics Clinical chemistry and laboratory medicine 2024 Landmark-class EUCAST Wild-Type MIC Distributions Provide the Reference Point for Resistance Detection Clinical microbiology reviews 2023 Landmark-class Whole-Genome Sequencing Finds Actionable Cancer Variants in 15% of Patients Where Standard Testing Failed Genome medicine 2023 Landmark-class RNA-Based Molecular Subtypes of Colorectal Liver Metastases Validated in Phase 3 Trial JAMA oncology 2023 Landmark-class Spatial Immune Cell Analysis in Cancer: Methods Compendium and Path to Clinical Utility The Journal of pathology 2023 Landmark-class Computational Pathology Promises Automation but Faces Major Adoption Hurdles The Journal of pathology 2023 Landmark-class Blood Neurofilament Light Predicts Progressive MS Disability After Anti-CD20 Therapy EBioMedicine 2023 Landmark-class EU IVDR Reshapes Companion Diagnostic Regulation: New Framework, New Challenges Clinical pharmacology and therapeutics 2023 Landmark-class ISO 15189 Can Satisfy IVDR Requirements for Laboratory Developed Tests, Expert Analysis Argues Clinical chemistry and laboratory medicine 2023 Landmark-class Practical Guide to Using Circulating Tumor DNA in Cancer Treatment Decisions JAMA oncology 2022 Landmark-class PET Imaging Biomarkers Predict Response to Lutetium-PSMA Therapy in Prostate Cancer The Lancet. Oncology 2022 Landmark-class Blood-based TMB fails primary endpoint as biomarker for atezolizumab in NSCLC Nature medicine 2022 Landmark-class Tertiary Lymphoid Structures Predict Immunotherapy Response in Soft-Tissue Sarcoma Nature medicine 2022 Landmark-class B-F1RST Trial: Blood-Based TMB Shows Promise but Needs Refinement for Immunotherapy Selection Nature medicine 2022 Landmark-class Atezolizumab Shows 38% Response Rate in TMB-High Tumors Across Multiple Cancer Types Cancer discovery 2022 Landmark-class Blood-Based Mass Spectrometry MRD Rivals Bone Marrow NGS in Multiple Myeloma Clinical chemistry 2021 Landmark-class What Lab Professionals Must Know About High-Sensitivity Troponin Assay Performance Clinical chemistry and laboratory medicine 2020 Landmark-class Personalised TB Risk Predictor Outperforms Crude Group-Based Approaches Nature medicine 2020 Landmark-class National Academies Workshop: Best Practices for Computational Methods in Precision Oncology JAMA oncology 2020 Landmark-class Pre-Salvage PSA Level Guides Hormone Therapy Benefit After Prostatectomy for Prostate Cancer JAMA oncology 2020 Landmark-class Folate Receptor Alpha Emerges as a Versatile Oncology Target and Predictive Biomarker Nature reviews. Clinical oncology 2020 Landmark-class Molecular Profiling for Precision Oncology: From NGS Panels to Liquid Biopsies Genome medicine 2020 Landmark-class Circulating Tumour Cells Move Beyond Counting to Multi-Omic Characterisation Clinical chemistry 2020 Landmark-class Procalcitonin Underperforms CRP and IL-6 for Pneumonia Diagnosis in Dyspnoea Patients Clinical chemistry 2019 Landmark-class Best Practices for Neoantigen Prediction in Personalised Cancer Vaccines Genome medicine 2019 Landmark-class Molecular Targets in Endometrial Cancer: From Histological to Genomic Subtyping Nature reviews. Cancer 2019 Landmark-class DNA Damage Response Biomarkers Guide Synthetic Lethal Cancer Therapy Beyond BRCA Nature reviews. Clinical oncology 2019 Landmark-class MGMT Methylation Independently Predicts Outcomes in Low-Grade Glioma Treated With Temozolomide JAMA oncology 2018 Landmark-class 28-Gene Hypoxia Signature Validated as Prognostic Biomarker in Localized Prostate Cancer EBioMedicine 2018 Landmark-class HER3 mRNA Expression Predicts Panitumumab Benefit in RAS Wild-Type Colorectal Cancer JAMA oncology 2018 Landmark-class Nucleotyping: Pan-Cancer Chromatin Biomarker Validated Across Seven Tumour Types The Lancet. Oncology 2018 Landmark-class Whole-Body MRI Detects Localized Cancers in 7% of Li-Fraumeni Patients at Baseline JAMA oncology 2017 Landmark-class Gene-Expression Signatures in Early Breast Cancer: Comparing Oncotype DX, MammaPrint, and Beyond Nature reviews. Clinical oncology 2017 Landmark-class Europe's U-PGx Consortium Launches Landmark Multi-Gene Pharmacogenomics Implementation Trial Clinical pharmacology and therapeutics 2017 Landmark-class BRCA Testing Must Expand Beyond Family History to Guide PARP Inhibitor Therapy in Ovarian Cancer Nature reviews. Clinical oncology 2016 Landmark-class Predictive Biomarkers for Checkpoint Immunotherapy: Beyond PD-L1 Alone The Lancet. Oncology 2016 Landmark-class Coronary Artery Calcium Found in One-Third of Low-Risk Women, Predicts Cardiovascular Events JAMA 2016 Landmark-class Crowdsourced DREAM Challenge Produces Superior Prognostic Model for Metastatic Prostate Cancer The Lancet. Oncology 2016 Landmark-class Ventana PD-L1 SP263 Assay Validated for NSCLC and Head and Neck Cancer Diagnostics Diagnostic pathology 2016 Landmark-class PD-L1 Testing in Lung Cancer: Multiple Assays and No Consensus Create a Biomarker Dilemma JAMA oncology 2016 Landmark-class Genetic Counselling Framework Proposed for Moderate-Penetrance Cancer Mutations Nature reviews. Clinical oncology 2016 Landmark-class AI and Machine Learning Transform Predictive Biomarker Discovery in Oncology Nature reviews. Clinical oncology 2026 Significance 7/10 Meta-Analysis of 10,000 Patients Defines Optimal Androgen Deprivation Duration for Prostate Cancer JAMA oncology 2026 Significance 7/10 From PKU to Genomics: Six Decades of Newborn Screening Evolution Clinical chemistry 2025 Significance 7/10 Biomarker-Driven Therapy in Urothelial Cancer: From FGFR3 Mutations to ctDNA Monitoring Nature reviews. Clinical oncology 2025 Significance 7/10 Metagenomic Sequencing for TB Diagnosis: Promise and Practical Barriers Journal of clinical microbiology 2025 Significance 7/10 Tumor-Infiltrating Lymphocytes Gain Ground as a Cost-Effective Breast Cancer Biomarker Human pathology 2025 Significance 7/10 Novel Methylglyoxal-Albumin Biomarker Predicts New-Onset Diabetes in Prediabetic Patients Clinical chemistry 2025 Significance 7/10 Pharmacogenomic Testing in Practice: Who, When, and Which Model to Use Clinical pharmacology and therapeutics 2025 Significance 7/10 Genomic Signatures May Enable Personalized Radiotherapy Decisions in Breast Cancer JAMA oncology 2025 Significance 7/10 Multi-Centre Italian Study Validates In-House HRD Testing as Reliable Alternative to Outsourced Assays Journal of clinical pathology 2024 Significance 7/10 Neural Antibody Testing for Autoimmune CNS Disorders: Assays, Panels, and Clinical Utility Clinical biochemistry 2024 Significance 7/10 Polygenic Risk Scores Near Clinical Use but Equity and Standardisation Lag Behind Genome medicine 2024 Significance 7/10 Anti-EGFR Antibody SCT200 Shows Promise in Refractory Colorectal Cancer; ctDNA Clearance Predicts Outcomes EBioMedicine 2024 Significance 7/10 Machine Learning for Personalized Drug Dosing: Systematic Review Finds High Potential but Poor Validation Clinical pharmacology and therapeutics 2023 Significance 7/10 International Working Group Identifies Key Pitfalls in ML-Based TIL Assessment for Breast Cancer The Journal of pathology 2023 Significance 7/10 ISUP Consensus: Bladder Cancer Molecular Subtypes Not Yet Ready for Routine Use The American journal of surgical pathology 2023 Significance 7/10 Regression Models Outperform Machine Learning for Breast Cancer Mortality Prediction BMJ (Clinical research ed.) 2023 Significance 7/10 Lipid Testing Is Evolving: Sampson-NIH Equation, ApoB, and Lp(a) Gain Ground Over Traditional LDL-C Clinical chemistry 2023 Significance 7/10 Ki67 in Breast Cancer: Pragmatic Use Despite Persistent Scoring Challenges Journal of clinical pathology 2023 Significance 7/10 Unified Framework Exposes Evidence Gaps in Neurological Protein Biomarkers EBioMedicine 2023 Significance 7/10 Removing Ethnicity from eGFR Equations: Rationale, Impact, and Remaining Questions Annals of clinical biochemistry 2023 Significance 7/10 Rethinking IVD Quality Control: A Two-Component IQC Model Tied to Clinical Performance Specs Clinical chemistry and laboratory medicine 2022 Significance 7/10 HCV Core Antigen Test Shows High Accuracy for Screening HIV-Coinfected Patients Journal of clinical microbiology 2022 Significance 7/10 USPSTF Evidence Review Finds Uncertain Benefit of Screening for Obstructive Sleep Apnea JAMA 2022 Significance 7/10 DAXX/ATRX Loss and ALT as Prognostic Biomarkers in Pancreatic Neuroendocrine Tumors Human pathology 2022 Significance 7/10 Extracellular Vesicle PD-L1 Emerges as Liquid Biopsy Biomarker for Immunotherapy Response NPJ precision oncology 2022 Significance 7/10 Comprehensive Review of Antimicrobial Susceptibility Testing Methods for Enterococci Journal of clinical microbiology 2022 Significance 7/10 CMV Cell-Mediated Immunity Assays Show Promise for Personalizing Transplant Management Journal of clinical microbiology 2022 Significance 7/10 Korean Pan-Cancer Sequencing Reveals Genomic Diversity Versus Western Cohorts Cancer discovery 2022 Significance 7/10 Combining Type I and Type II KIT Inhibitors Shows Promise in Refractory GIST, Guided by ctDNA Monitoring JAMA oncology 2021 Significance 7/10 Postoperative ctDNA Predicts Recurrence After Colorectal Cancer Liver Metastasis Resection EBioMedicine 2021 Significance 7/10 Pharmacogenomics in colorectal cancer: from DPYD testing to companion diagnostics Clinical pharmacology and therapeutics 2021 Significance 7/10 SMAD4 Alteration Plus Low MAPK9 Expression Predicts Erlotinib Benefit in Resected Pancreatic Cancer EBioMedicine 2021 Significance 7/10 Patient-Derived Models Reshape Biomarker Validation in Colorectal Cancer Cancer discovery 2021 Significance 7/10 Clinically Applicable 53-Gene Assay Predicts Survival and Chemotherapy Benefit in Gastric Cancer EBioMedicine 2020 Significance 7/10 Viral Load Testing in Transplant Medicine Hampered by Poor Assay Standardisation Journal of clinical microbiology 2020 Significance 7/10 Tumour Budding Validated as Prognostic Biomarker Across Solid Cancers Nature reviews. Clinical oncology 2020 Significance 7/10 Combining MRI and Gene-Based Hypoxia Biomarkers Improves Chemoradiotherapy Failure Prediction in Cervical Cancer EBioMedicine 2020 Significance 7/10 Polygenic Risk Scores: Promising but Not Yet Ready for Clinical Diagnostics Genome medicine 2020 Significance 7/10 Epigenetic Mutations in CREBBP and IDH2 Predict Poor Outcomes in Peripheral T-Cell Lymphoma Genome medicine 2020 Significance 7/10 ST2 Biomarker Predicts Non-Relapse Mortality After Stem Cell Transplant in Children and Adults Blood 2020 Significance 7/10 Phase 3 ANNOUNCE Trial: Olaratumab Fails to Confirm Survival Benefit in Soft Tissue Sarcoma JAMA 2020 Significance 7/10 Immunotherapy in Small-Cell Lung Cancer: Biomarker Strategies Remain Elusive Nature reviews. Clinical oncology 2020 Significance 7/10 Targeted NGS Panel Validates TMB as Predictor of Checkpoint Inhibitor Response in NSCLC The Journal of pathology 2019 Significance 7/10 Making the Case for Advanced Microbiology Tests: A Framework for Demonstrating Clinical Utility to Payers Journal of clinical microbiology 2019 Significance 7/10 Off-Label Predictive Biomarkers in GI Cancers: When Should Pathologists Say Yes? Diagnostic pathology 2019 Significance 7/10 Lung Tumor Microenvironment as a Source of Prognostic Biomarkers and Therapeutic Targets Nature reviews. Cancer 2019 Significance 7/10 Circulating Non-Coding RNAs as Cancer Biomarkers: From miRNAs to Xeno-miRNAs Nature reviews. Clinical oncology 2018 Significance 7/10 Tumor-Normal Sequencing Uncovers Secondary Germline Findings in Cancer Patients The Journal of pathology 2018 Significance 7/10 Dual PET/CT Imaging Reveals Prognostic Tumour Heterogeneity in Castration-Resistant Prostate Cancer JAMA oncology 2018 Significance 7/10 Nivolumab plus ipilimumab shows promise in specific sarcoma subtypes The Lancet. Oncology 2018 Significance 7/10 Companion diagnostics in oncology: 20 years of FDA-approved assays reviewed Clinical pharmacology and therapeutics 2017 Significance 7/10 FOXP1 Protein Expression Predicts Outcome in Rituximab-Treated Follicular Lymphoma Blood 2017 Significance 7/10 Umbrella, Basket, and Platform Trials: What Oncology Has Learned From New Biomarker-Driven Designs Clinical pharmacology and therapeutics 2017 Significance 7/10 MAF Amplification Predicts Zoledronic Acid Benefit in Breast Cancer, Potential Companion Diagnostic The Lancet. Oncology 2017 Significance 7/10 HER2-Positive Breast Cancer Lacks Validated Predictive Biomarkers Beyond HER2 Itself Nature reviews. Clinical oncology 2017 Significance 7/10 KRAS-Variant Germline Mutation Predicts Cetuximab Benefit in Head and Neck Cancer JAMA oncology 2017 Significance 7/10 Blood-Based Protein Signatures Could Enable Early Cancer Detection Nature reviews. Cancer 2017 Significance 7/10 Glasgow Blatchford Score Best at Predicting Need for Intervention in Upper GI Bleeding BMJ (Clinical research ed.) 2017 Significance 7/10 Metabolic Imaging Biomarkers Offer a Non-Invasive Window into Brain Tumor Biology Nature reviews. Clinical oncology 2016 Significance 7/10 Meta-Analysis Finds (-2)proPSA Accuracy for Prostate Cancer Remains Uncertain Clinical chemistry and laboratory medicine 2016 Significance 7/10 SPAG5 Identified as Amplified Prognostic and Chemotherapy-Predictive Biomarker in Breast Cancer The Lancet. Oncology 2016 Significance 7/10 Beyond EpCAM: Non-Epithelial Methods for Capturing Circulating Tumor Cells Clinical chemistry 2016 Significance 7/10 Autoantibody Testing in Neuromuscular Disease: Assays, Interpretation, and Clinical Impact Clinical biochemistry 2026 Significance 6/10 HOXA gene dysregulation in AML: from molecular mechanisms to menin inhibitor resistance NPJ precision oncology 2025 Significance 6/10 Vimseltinib achieves 40% response rate in tenosynovial giant cell tumour phase 3 trial Lancet (London, England) 2024 Significance 6/10 Cardiac Troponin and BNP Show Untapped Potential for Cardiovascular Risk Assessment in Pregnancy Clinical chemistry and laboratory medicine 2023 Significance 6/10 Creatinine vs. Cystatin C: A Practical Guide to Renal Biomarkers and eGFR Equations Annals of laboratory medicine 2023 Significance 6/10 How to Measure Clinical Utility of Diagnostic Tests: A Methods Review for Lab Professionals Clinical biochemistry 2023 Significance 6/10 Systematic Review Maps Prognostic Biomarker Landscape for Male Breast Cancer The Lancet. Oncology 2023 Significance 6/10 DAXX/ATRX and ALT Testing Refines Pancreatic Neuroendocrine Tumor Classification (Reprint) Human pathology 2023 Significance 6/10 Rethinking Histopathology Reporting: Focus on What Changes Patient Management Journal of clinical pathology 2022 Significance 6/10 Breast Pathology Data That Drives Treatment: A Clinical Utility Guide for Reporting Pathologists Journal of clinical pathology 2022 Significance 6/10 PAX8 and CDX2 Can Stain Positive in Breast Cancer, Risking Misdiagnosis of Tumor Origin Human pathology 2022 Significance 6/10 PD-L1-Positive Circulating Tumour Cells Emerge as Prognostic Marker in Advanced NSCLC Clinical chemistry 2021 Significance 6/10 Pembrolizumab-cetuximab combination shows 45% response rate in head and neck cancer The Lancet. Oncology 2021 Significance 6/10 Novel Biomarkers Show Promise for Monitoring Anti-TNF Therapy in IBD EBioMedicine 2021 Significance 6/10 Patient-Derived Organoids as Predictive Biomarker for Cancer Treatment Response NPJ precision oncology 2021 Significance 6/10 suPAR Combined With NT-proBNP and HEART Score Achieves 99% Negative Predictive Value in Chest Pain Clinical biochemistry 2021 Significance 6/10 Canadian Consensus Guidance on SARS-CoV-2 Serology Testing and Reporting Clinical biochemistry 2020 Significance 6/10 M2BPGi Emerges as a Versatile Serum Marker for Liver Fibrosis and HCC Risk Annals of laboratory medicine 2020 Significance 6/10 Cardiac Troponin in COVID-19: Elevated but Mostly Stable, Not Acute Coronary Syndrome Annals of clinical biochemistry 2020 Significance 6/10 suPAR Predicts Non-Cardiac Mortality After Primary PCI for STEMI Clinical biochemistry 2020 Significance 6/10 T-VEC Plus Pembrolizumab Achieves 35% Response Rate in Advanced Sarcoma JAMA oncology 2020 Significance 6/10 Pathologists Need Consensus on CD30 Detection and Reporting in Lymphoma The American journal of surgical pathology 2020 Significance 6/10 Breast Cancer Immunoassays Shift Toward Electrochemiluminescence and Automation Clinical biochemistry 2020 Significance 6/10 Hyperprogression on Immunotherapy: Identifying Patients Whose Tumours Accelerate Under Checkpoint Blockade Genome medicine 2019 Significance 6/10 Ethical Framework for Returning Epigenetic Research Results to Participants Genome medicine 2019 Significance 6/10 IMP3 Plus L1CAM Immunohistochemistry Optimises Grading of Endometrial Carcinomas Human pathology 2019 Significance 6/10 Avelumab Shows Modest Activity in Heavily Pretreated Ovarian Cancer, PD-L1 Status Explored JAMA oncology 2019 Significance 6/10 Alternative Medicine Labs Sell Unvalidated Tests With Misleading Interpretations Annals of clinical biochemistry 2019 Significance 6/10 Thyroid Laboratory Testing: A Practical Guide to Pitfalls and Clinical Interpretation Annals of laboratory medicine 2019 Significance 6/10 PACE Framework Aims to Make Preemptive Pharmacogenomics Testing Routine Clinical pharmacology and therapeutics 2018 Significance 6/10 Serum SETD7 Emerges as Novel Diagnostic Biomarker for Colorectal Cancer EBioMedicine 2018 Significance 6/10 Hair Cortisol Analysis Offers a Unique Window Into Long-Term Stress Hormones Clinical biochemistry 2018 Significance 6/10 Dasatinib Shows Activity in Imatinib-Resistant GIST; pSRC May Identify Responders JAMA oncology 2018 Significance 6/10 HCV Core Antigen Testing Matures into a Practical Alternative to RNA Detection Clinical chemistry and laboratory medicine 2018 Significance 6/10 EZH1 Mutations Help Classify Follicular Thyroid Tumours as Likely Benign Human pathology 2018 Significance 6/10 Aurora A SNP at Codon 57 Predicts Response to Alisertib in Advanced Solid Tumors EBioMedicine 2017 Significance 6/10 Ep-CAM Meta-Analysis: High Diagnostic Accuracy and Prognostic Value in Colorectal Cancer EBioMedicine 2017 Significance 6/10 Harmonising Interpretive Comments on Lab Results: Still a Long Way to Go Clinical biochemistry 2017 Significance 6/10 Returning Germline Findings from Cancer Genomics Research: Lessons from the Australian Pancreatic Cancer Genome Initiative Genome medicine 2017 Significance 6/10 c-MET Inhibition in GI Cancers: Biomarker Stratification Remains the Key Challenge Nature reviews. Clinical oncology 2017 Significance 6/10 New Antibiotics for Skin Infections Address Growing Resistance Challenges BMJ (Clinical research ed.) 2016 Significance 6/10 Bone Turnover Markers Add Prognostic Value but Preanalytic Pitfalls Persist Clinical chemistry 2016 Significance 6/10 CDK4 Inhibitor Palbociclib Shows Favorable PFS in CDK4-Amplified Liposarcoma JAMA oncology 2016 Significance 6/10 Digital E-Training Matches Live Training for Pathologists Learning Companion Diagnostic IHC Scoring Human pathology 2016 Significance 6/10 Tumor-Associated B Cells Linked to Better Survival in Primary Melanoma Human pathology 2016 Significance 6/10 Precision oncology trials need standardised biomarker reporting to unlock their data Clinical chemistry 2015 Significance 6/10 Rapid Detection of C. difficile BI/NAP1/027: Useful for Infection Control but Specificity Concerns Remain Journal of clinical microbiology 2015 Significance 6/10 18-Gene Signature Predicts Survival in Gastric Cancer via Lymphatic Endothelial Cell Pathways Diagnostic pathology 2025 Significance 5/10 Post-Neoadjuvant Breast Pathology: Current Reporting Standards and Biomarker Testing Controversies Human pathology 2025 Significance 5/10 Predictive Model Identifies Children With Vasovagal Syncope Who Will Respond to Metoprolol EBioMedicine 2025 Significance 5/10 Adenovirus Diagnostics Lag Behind: Clinical Labs Hold Untapped Research Potential Journal of clinical microbiology 2024 Significance 5/10 Urinary Angiogenin Confirmed as Reliable Biomarker for Early Bladder Cancer Detection Clinical biochemistry 2024 Significance 5/10 Macroscopic Specimen Handling in Urological Pathology Needs a Rethink Journal of clinical pathology 2024 Significance 5/10 Gut Microbiota Emerges as Diagnostic Biomarker and Therapeutic Target in Diabetes EBioMedicine 2023 Significance 5/10 Defining Clinical Utility: A Framework for Evaluating Whether Diagnostic Tests Improve Outcomes Clinical biochemistry 2023 Significance 5/10 Platelet Distribution Width Emerges as Prognostic Marker in COVID-19 Severity and Mortality Clinical chemistry and laboratory medicine 2023 Significance 5/10 How GI Pathology Reports Drive Clinical Decisions: Key Data Items That Matter Journal of clinical pathology 2022 Significance 5/10 When Pathology Data Items Matter and When They Don't: A Urological Cancer Perspective Journal of clinical pathology 2022 Significance 5/10 Platelet Function Analyser Approaching 50 Years: Strengths, Limits, and Clinical Role Clinical chemistry and laboratory medicine 2022 Significance 5/10 Risankizumab shows strong induction efficacy in Crohn's disease across two phase 3 trials Lancet (London, England) 2022 Significance 5/10 Risankizumab maintains remission in Crohn's disease in phase 3 FORTIFY trial Lancet (London, England) 2022 Significance 5/10 Prealbumin as a Nutritional Biomarker: Clinical Value and Analytical Challenges Annals of clinical biochemistry 2020 Significance 5/10 Keratin 17 Identified as Negative Prognostic Marker in High-Grade Endometrial Cancer Human pathology 2019 Significance 5/10 COPD Drug Development: New Biomarkers and Regulatory Guidance Reshape Clinical Trials Clinical pharmacology and therapeutics 2019 Significance 5/10 Machine learning in medicine: bridging AI-driven diagnostics and medical education NPJ digital medicine 2018 Significance 5/10 Brazil Charts a Path for Companion Diagnostics Amid Complex Health System Challenges The Lancet. Oncology 2016 Significance 5/10 Copeptin Reviewed as Surrogate Biomarker for Vasopressin in Pediatric Diseases Clinical chemistry and laboratory medicine 2024 Significance 4/10 MMP-7 Reviewed as Cancer Biomarker and Therapeutic Target Clinical biochemistry 2021 Significance 4/10 Upper Airway Surgery Beats Medical Management for Moderate-to-Severe Sleep Apnea in SAMS Trial JAMA 2020 Significance 4/10 Cannabidiol for Drug-Resistant Epilepsy: Early Evidence of Anticonvulsant Efficacy Clinical pharmacology and therapeutics 2016 Significance 4/10 TRPV6 Shows Sex-Dependent Prognostic Value in Esophageal Squamous Cell Carcinoma Diagnostic pathology 2016 Significance 4/10 Review highlights challenges in developing reliable gastric cancer peritoneal metastasis models EBioMedicine 2023 Significance 3/10

ctDNA-Detected ESR1 Mutations Guide First-Line Switch to Camizestrant in Advanced Breast Cancer The New England journal of medicine 2025 Landmark-class ddPCR-Based ctDNA Predicts Recurrence in Resected Stage III Melanoma on COMBI-AD Trial The Lancet. Oncology 2025 Landmark-class FIT-Based Colorectal Screening Non-Inferior to Colonoscopy for Cancer Mortality at 10 Years Lancet (London, England) 2025 Landmark-class ADAURA MRD Analysis: ctDNA Detects Recurrence 4.7 Months Before Imaging in Resected NSCLC Nature medicine 2025 Landmark-class DYNAMIC Trial 5-Year Data Validate ctDNA-Guided Adjuvant Chemotherapy De-Escalation in Stage II Colon Cancer Nature medicine 2025 Landmark-class Prenatal cfDNA Screening Incidentally Detects Occult Maternal Cancer in Nearly Half of Unusual Results The New England journal of medicine 2024 Landmark-class ProBio Platform Trial Uses ctDNA to Guide Treatment Selection in Metastatic Prostate Cancer Nature medicine 2024 Landmark-class FDA-Aligned Meta-Analysis Validates MRD Negativity as Surrogate Endpoint in Myeloma Blood 2024 Landmark-class Blinatumomab Added to Chemotherapy Improves Survival in MRD-Negative Adult ALL The New England journal of medicine 2024 Landmark-class Venetoclax-Obinutuzumab Combinations Show Superior 4-Year PFS Over Chemoimmunotherapy in CLL The Lancet. Oncology 2024 Landmark-class Meta-Analysis: ctDNA-Based MRD Detection Strongly Predicts Recurrence Across Resectable Cancers EBioMedicine 2024 Landmark-class Shield Blood Test Achieves 83% Sensitivity for Colorectal Cancer in ECLIPSE Screening Trial The New England journal of medicine 2024 Landmark-class CHRONOS Trial: ctDNA-Guided Anti-EGFR Rechallenge Shows 30% Response in Colorectal Cancer Nature medicine 2022 Landmark-class DYNAMIC Trial: ctDNA-Guided Therapy Halves Chemotherapy Use in Stage II Colon Cancer Without Compromising Outcomes The New England journal of medicine 2022 Landmark-class ELN 2021 MRD Consensus Introduces NGS Specifications and Integrative Assessment for AML Blood 2021 Landmark-class Stockholm3 Blood Test Plus MRI Outperforms Standard PSA Screening for Prostate Cancer The Lancet. Oncology 2021 Landmark-class MRI-Targeted Biopsy Halves Clinically Insignificant Prostate Cancer Detection in Screening The New England journal of medicine 2021 Landmark-class ctDNA Identifies Urothelial Cancer Patients Who Benefit from Adjuvant Atezolizumab Nature 2021 Landmark-class Largest Ovarian Cancer Screening Trial Finds No Mortality Benefit After 16 Years Lancet (London, England) 2021 Landmark-class Multi-Site Benchmarking Study Defines Analytical Performance Boundaries of Leading ctDNA Assays Nature biotechnology 2021 Landmark-class Landmark Perspective Charts the Path from Approved Liquid Biopsy Assays to ctDNA-Guided Relapse Detection Nature reviews. Clinical oncology 2021 Landmark-class Meta-Analysis of 11,151 AML Patients Confirms MRD Negativity Nearly Doubles Survival JAMA oncology 2020 Landmark-class Lung-MAP Master Protocol Delivers Biomarker-Driven Results in Squamous NSCLC The Lancet. Oncology 2020 Landmark-class Implementing Plasma-Based ctDNA Genotyping in NSCLC Clinical Practice Nature reviews. Clinical oncology 2020 Landmark-class plasmaMATCH: ctDNA-Directed Therapy Platform Trial Validates Liquid Biopsy for Breast Cancer Genotyping The Lancet. Oncology 2020 Landmark-class Machine Learning Method Lung-CLiP Distinguishes Early Lung Cancer from Controls Using ctDNA Features Nature 2020 Landmark-class Ultra-Deep cfDNA Sequencing Reveals Clonal Haematopoiesis as the Dominant Source of Plasma Mutations Nature medicine 2019 Landmark-class CASSIOPEIA Trial Establishes Daratumumab-VTd as Standard Induction for Transplant-Eligible Myeloma Lancet (London, England) 2019 Landmark-class NEJM Review Establishes Clinical Framework for Cell-Free DNA Analysis in Cancer Treatment The New England journal of medicine 2018 Landmark-class Tisagenlecleucel CAR-T Therapy Achieves 81% Remission in Paediatric Relapsed ALL The New England journal of medicine 2018 Landmark-class Serum DNA methylation marker EFC#93 detects lethal breast cancer months before diagnosis Genome medicine 2017 Landmark-class Daratumumab-VMP Nearly Halves Disease Progression in Transplant-Ineligible Myeloma The New England journal of medicine 2017 Landmark-class Meta-Analysis Confirms MRD Negativity Predicts Superior Survival in Multiple Myeloma JAMA oncology 2017 Landmark-class ELN 2017 Recommendations Establish Genomic Risk Classification and MRD Framework for AML Blood 2016 Landmark-class Daratumumab Added to Lenalidomide-Dexamethasone Significantly Improves MRD Negativity in Relapsed Myeloma The New England journal of medicine 2016 Landmark-class Plasma ddPCR Detects EGFR and KRAS Mutations in Lung Cancer with 100% Positive Predictive Value JAMA oncology 2016 Landmark-class IMWG Consensus Criteria Define MRD Negativity as New Response Endpoint in Multiple Myeloma The Lancet. Oncology 2016 Landmark-class Inotuzumab Ozogamicin Achieves 81% Remission with Superior MRD Clearance in Relapsed ALL The New England journal of medicine 2016 Landmark-class NPM1 Mutation Tracking by RT-qPCR Is the Strongest Prognostic Factor in Standard-Risk AML The New England journal of medicine 2016 Landmark-class UKCTOCS: multimodal ovarian cancer screening shows 20% mortality reduction when prevalent cases excluded Lancet (London, England) 2015 Landmark-class Liquid Biopsy and Radiomics Show Promise for Lung Cancer Screening Beyond CT Nature reviews. Clinical oncology 2026 Landmark-class Postoperative ctDNA Predicts Celecoxib Benefit in Stage III Colon Cancer JAMA oncology 2026 Landmark-class Cell-Free DNA Model Detects Pancreatic Cancer Up to 298 Days Before Clinical Diagnosis Cancer discovery 2026 Landmark-class Nature Medicine Review Positions Liquid Biopsy Across the Full Cancer Care Continuum Nature medicine 2025 Landmark-class Focused Ultrasound Plus Temozolomide Achieves 31-Month Median Survival in Glioblastoma With Sono-Liquid Biopsy The Lancet. Oncology 2025 Landmark-class Non-Operative Management After Total Neoadjuvant Therapy Preserves Organs in Rectal Cancer Without Compromising Survival The Lancet. Oncology 2025 Landmark-class Epcoritamab Plus R2 Achieves 88% Complete Response and 86% MRD Negativity in Relapsed Follicular Lymphoma Blood 2025 Landmark-class Targeting Dormant Tumour Cells with Everolimus and Hydroxychloroquine Depletes Minimal Residual Disease in Breast Cancer Nature medicine 2025 Landmark-class Combined PET and ctDNA Response Predicts Early Progression in Follicular Lymphoma with 86% Positive Predictive Value Blood 2025 Landmark-class Early ctDNA Response Predicts Immunotherapy Outcomes in MSI-High Metastatic Colorectal Cancer JAMA oncology 2025 Landmark-class Isatuximab-Carfilzomib Quadruplet Induction Achieves 63% MRD Negativity in Newly Diagnosed Myeloma Blood 2025 Landmark-class Second Large Validation Study Confirms Blood-Based ctDNA Test Detects 79% of Colorectal Cancers JAMA 2025 Landmark-class Multi-Cancer Early Detection via Liquid Biopsy: Promises, Pitfalls, and What Comes Next Nature reviews. Clinical oncology 2025 Landmark-class New Colorectal Cancer Screening Methods: cfDNA Blood Tests and Improved Stool Biomarkers Nature reviews. Clinical oncology 2025 Landmark-class MURANO Final Analysis Shows 7-Year Durability of MRD-Guided Venetoclax-Rituximab in CLL Blood 2025 Landmark-class IMpassion031 Final Results: ctDNA Dynamics Add Prognostic Value Beyond Pathologic Response in TNBC Nature medicine 2025 Landmark-class ctDNA Fraction Predicts PSMA-Targeted Radioligand Therapy Response in Metastatic Prostate Cancer Nature medicine 2025 Landmark-class FLT3-ITD MRD Levels Predict Relapse and Guide Gilteritinib Maintenance After Transplant Blood 2025 Landmark-class Comprehensive Review Maps the cfDNA Fragmentome as a Multi-Feature Platform for Early Cancer Detection Nature reviews. Cancer 2025 Landmark-class Personalised Neoantigen Vaccine Targets Driver Mutations and Prevents Recurrence in Renal Cell Carcinoma Nature 2025 Landmark-class Daratumumab-Lenalidomide Maintenance Doubles MRD-Negative Conversion After Transplant in Myeloma Blood 2025 Landmark-class Baseline ctDNA Level and Early Clearance Predict Survival in Locally Advanced Rectal Cancer EBioMedicine 2025 Landmark-class CA-125 screening offers a 12-month window for early-stage ovarian cancer detection EBioMedicine 2025 Landmark-class Pantel and Alix-Panabieres Outline How ctDNA-Guided MRD Detection Could Enable Curative Post-Adjuvant Therapy Nature reviews. Clinical oncology 2024 Landmark-class cfDNA Fragmentome Blood Test Validated for Augmenting Lung Cancer Screening Cancer discovery 2024 Landmark-class Standing Platform Proposed for ctDNA-Guided Cancer Drug Development in Molecular Evidence of Disease Nature reviews. Cancer 2024 Landmark-class BEACON CRC Biomarker Analysis Reveals Resistance Mechanisms to BRAF-Targeted Therapy via ctDNA Profiling Nature medicine 2024 Landmark-class BRCA1/2 Testing in Males Demands Greater Clinical Attention Given Expanding Therapeutic Options JAMA oncology 2024 Landmark-class Systematic Review Validates Undetectable MRD as PFS Surrogate in CLL Treated with Targeted Agents JAMA oncology 2024 Landmark-class Peripheral Blood Mass Spectrometry Provides Non-Invasive MRD Assessment in Post-Transplant Myeloma Blood 2024 Landmark-class Postoperative ctDNA Positivity Strongly Predicts Recurrence in Resectable Pancreatic Cancer JAMA oncology 2024 Landmark-class ctDNA Outperforms Flow Cytometry for Early Relapse Detection in CLL Triple-Combination Therapy Blood 2024 Landmark-class ctDNA-Guided TKI De-Escalation in Advanced NSCLC Enables Median 9-Month Treatment Breaks JAMA oncology 2024 Landmark-class Five-Drug ViPOR Regimen Achieves Durable Remissions in Molecular Subtypes of Relapsed DLBCL The New England journal of medicine 2024 Landmark-class BFAST Trial Validates Liquid Biopsy-Guided Entrectinib for ROS1-Positive Lung Cancer Nature medicine 2024 Landmark-class CASSIOPEIA Long-Term Follow-Up Confirms Daratumumab Maintenance Benefit with MRD-Guided Monitoring The Lancet. Oncology 2024 Landmark-class Ponatinib Doubles MRD-Negative Complete Remission Rate Versus Imatinib in Ph+ ALL JAMA 2024 Landmark-class Adagrasib Plus Cetuximab Shows 34% Response Rate in KRASG12C-Mutated Colorectal Cancer Cancer discovery 2024 Landmark-class Donor-Derived Cell-Free DNA Validates as Noninvasive Biomarker for Kidney Transplant Rejection Nature medicine 2024 Landmark-class MRI Integration in Prostate Cancer Screening Halves Unnecessary Biopsies Without Missing Clinically Significant Cancer JAMA oncology 2024 Landmark-class Belantamab Mafodotin Combination Triples Progression-Free Survival in Relapsed Myeloma The New England journal of medicine 2024 Landmark-class ctDNA Dynamics Reveal Distinct Response Patterns to Immunotherapy vs Chemotherapy in Metastatic Urothelial Cancer Nature medicine 2024 Landmark-class Felzartamab Resolves Antibody-Mediated Kidney Transplant Rejection in Phase 2 Trial The New England journal of medicine 2024 Landmark-class Three-Step PSA-Kallikrein-MRI Protocol Detects More Aggressive Prostate Cancers With Less Overdiagnosis JAMA 2024 Landmark-class Expanded Prenatal cfDNA Screening Detects Aneuploidies, Microdeletions and Monogenic Variants in a Single Test Nature medicine 2024 Landmark-class Clinical Practice Guideline Establishes Standards for Blood-Based ctDNA Assays Annals of laboratory medicine 2024 Landmark-class KRAS-Targeted Amphiphile Vaccine Induces T Cell Responses and ctDNA Clearance in Pancreatic and Colorectal Cancer Nature medicine 2024 Landmark-class cfDNA-Based PreCar Score Doubles Early Hepatocellular Carcinoma Detection Sensitivity Versus Ultrasound EBioMedicine 2024 Landmark-class ctDNA Reveals KIT Mutation-Dependent Drug Sensitivity in GIST: INTRIGUE Trial Biomarker Analysis Nature medicine 2024 Landmark-class Multitarget Stool RNA Test Significantly Outperforms FIT for Colorectal Cancer and Advanced Adenoma Detection JAMA 2023 Landmark-class Sequential CD19 and CD22 CAR-T Therapy Achieves 97% Response and Durable MRD-Negative Remissions in Childhood B-ALL The Lancet. Oncology 2023 Landmark-class BR.36 Trial Validates ctDNA Molecular Response at Cycle 3 as Predictor of Pembrolizumab Outcome in NSCLC Nature medicine 2023 Landmark-class Phase 1 Trial of KRAS G12C Inhibitor Divarasib Shows Durable Responses with Serial ctDNA Monitoring The New England journal of medicine 2023 Landmark-class Liquid Biopsy-Guided Anti-EGFR Rechallenge Shows Benefit in Refractory RAS Wild-Type Colorectal Cancer JAMA oncology 2023 Landmark-class Early ctDNA Reduction Predicts Survival Benefit from Tebentafusp in Uveal Melanoma Nature medicine 2022 Landmark-class KEYNOTE-564 Update Confirms Adjuvant Pembrolizumab Benefit in Renal Cell Carcinoma at 30 Months The Lancet. Oncology 2022 Landmark-class INTEGA Trial: Nivolumab-Trastuzumab Plus FOLFOX Outperforms Ipilimumab Arm in ERBB2-Positive Gastric Cancer JAMA oncology 2022 Landmark-class Temozolomide Priming Induces Mismatch Repair Deficiency and Sensitises Colorectal Tumours to Immunotherapy Cancer discovery 2022 Landmark-class Ponte-di-Legno Consortium Establishes International Consensus on MRD-Based Response Definitions in Pediatric ALL Blood 2022 Landmark-class Sustained MRD Negativity Predicts Superior PFS in Transplant-Ineligible Myeloma Treated with Daratumumab Blood 2022 Landmark-class ctDNA Minimal Residual Disease Emerges as a Transformative Biomarker for Predicting Solid Tumour Relapse Cancer discovery 2021 Landmark-class ctDNA Genotyping Matches Tissue Testing for HER2-Amplified Colorectal Cancer Treatment Selection Nature medicine 2021 Landmark-class Large Phase 3 Trial Shows Vincristine-Dexamethasone Pulses Can Be Safely Omitted in Low-Risk Childhood ALL The Lancet. Oncology 2021 Landmark-class KTE-X19 CAR-T Achieves 71% Complete Remission with 97% MRD Negativity in Adult Relapsed ALL Lancet (London, England) 2021 Landmark-class Beyond Sequence: Epigenomics, Fragmentomics, and Topology Expand Cell-Free DNA Analysis Science (New York, N.Y.) 2021 Landmark-class Blinatumomab Outperforms Chemotherapy in Children with High-Risk First-Relapse B-ALL JAMA 2021 Landmark-class Ide-cel CAR-T Therapy Achieves 73% Response and 26% MRD Negativity in Heavily Pretreated Myeloma The New England journal of medicine 2021 Landmark-class Circulating Tumour DNA Validated as Independent Prognostic Biomarker in BRAF-Mutant Melanoma The Lancet. Oncology 2021 Landmark-class Universal Genetic Testing in Cancer Patients Finds 6% More Actionable Variants Than Guideline-Directed Testing JAMA oncology 2021 Landmark-class Lancet Seminar Defines the Diagnostic and MRD Landscape of Multiple Myeloma Lancet (London, England) 2021 Landmark-class Serial ctDNA Monitoring Predicts Treatment Response in KRAS-Mutant Metastatic Colorectal Cancer Clinical chemistry 2020 Landmark-class Chemotherapy-Free Dasatinib-Blinatumomab Strategy Yields 60% Molecular Response in Ph+ ALL The New England journal of medicine 2020 Landmark-class Combined ctDNA and CTC Detection After Neoadjuvant Chemotherapy Predicts Recurrence in Triple-Negative Breast Cancer JAMA oncology 2020 Landmark-class mRNA-1273 Vaccine Phase 1 Trial Demonstrates Robust Antibody and Neutralisation Response Against SARS-CoV-2 The New England journal of medicine 2020 Landmark-class NCI Whitepaper Defines ctDNA Applications Across Colorectal Cancer Management Nature reviews. Clinical oncology 2020 Landmark-class Plasma Tumor Mutation Burden Identifies Colorectal Cancer Patients Benefiting from Dual Checkpoint Inhibition JAMA oncology 2020 Landmark-class Tepotinib Achieves 46% Response Rate in MET Exon 14 Skipping NSCLC with Liquid and Tissue Biopsy Concordance The New England journal of medicine 2020 Landmark-class Clonal Hematopoiesis Complicates MRD Assessment in Acute Myeloid Leukemia Blood 2020 Landmark-class Mass Spectrometry Methods Transform M-Protein Detection and MRD Monitoring in Myeloma Clinical chemistry 2020 Landmark-class Pre-Transplant Molecular MRD Strongly Predicts Outcome in NPM1-Mutated AML Blood 2020 Landmark-class Post-Surgery and Post-Chemotherapy ctDNA Predicts Recurrence Risk in Stage III Colon Cancer JAMA oncology 2019 Landmark-class BMJ Guideline: FIT, Sigmoidoscopy, and Colonoscopy All Offer Similar Colorectal Cancer Mortality Reduction BMJ (Clinical research ed.) 2019 Landmark-class Personalised ctDNA Assays Detect Breast Cancer Molecular Relapse 10.7 Months Before Clinical Recurrence JAMA oncology 2019 Landmark-class Single-Cell CTC Profiling Reveals Tumour Heterogeneity Beyond What ctDNA Can Capture Nature reviews. Cancer 2019 Landmark-class Pantel and Alix-Panabieres Define Liquid Biopsy Technologies for Minimal Residual Disease Surveillance Nature reviews. Clinical oncology 2019 Landmark-class Preanalytical Guidelines for Circulating Cell-Free DNA Analysis: A Systematic Review Clinical chemistry 2019 Landmark-class NTRK Fusions in Cancer: Detection Strategies and Targeted TRK Inhibitor Therapy Nature reviews. Clinical oncology 2018 Landmark-class ctDNA as a Biomarker for Immunotherapy Response: Monitoring Pseudoprogression and Resistance Nature reviews. Clinical oncology 2018 Landmark-class Standard Clinical Chemistry Validation Protocols Successfully Applied to ddPCR Liquid Biopsy Assays Clinical chemistry 2018 Landmark-class PALOMA-3 ctDNA Analysis Maps Resistance Evolution to Palbociclib Plus Fulvestrant in Breast Cancer Cancer discovery 2018 Landmark-class BMJ guideline recommends against routine PSA screening for prostate cancer BMJ (Clinical research ed.) 2018 Landmark-class Meta-Analysis Questions Mortality Benefit of PSA-Based Prostate Cancer Screening BMJ (Clinical research ed.) 2018 Landmark-class ctDNA Shows Promise for Early NSCLC Screening and Post-Surgical MRD Detection Despite Technical Challenges Nature reviews. Clinical oncology 2018 Landmark-class Prenatal Cell-Free DNA Testing: How Genomic Screening Transformed Prenatal Care The New England journal of medicine 2018 Landmark-class ctDNA and MSI/EBV Status Predict Dramatic Responses to Pembrolizumab in Metastatic Gastric Cancer Nature medicine 2018 Landmark-class Clinical Genomics in Oncology: From Targeted Therapy to Mutational Load and Vaccine Design Nature reviews. Clinical oncology 2018 Landmark-class USPSTF Evidence Review: PSA Screening Reduces Mortality but Carries Substantial Overdiagnosis Risk JAMA 2018 Landmark-class Single PSA Test Does Not Reduce Prostate Cancer Deaths in UK CAP Trial at 10 Years JAMA 2018 Landmark-class USPSTF Review Confirms No Mortality Benefit From Ovarian Cancer Screening in Average-Risk Women JAMA 2018 Landmark-class Targeting Minimal Residual Disease Emerges as a Viable Path Toward Cancer Cure Nature reviews. Cancer 2018 Landmark-class Blinatumomab Achieves 78% Complete MRD Response in Adults with MRD-Positive ALL Blood 2018 Landmark-class Tumour Heterogeneity Drives Resistance: Implications for Liquid Biopsy Monitoring Nature reviews. Clinical oncology 2017 Landmark-class Liquid Biopsies for Early Cancer Detection: Promise and Biological Challenges NPJ precision oncology 2017 Landmark-class Anti-Inflammatory Drug Canakinumab Slashes Lung Cancer Incidence in CANTOS Trial Lancet (London, England) 2017 Landmark-class Meta-Analysis Confirms Strong Prognostic Value of MRD Negativity in Pediatric and Adult ALL JAMA oncology 2017 Landmark-class IFM 2009 Trial Confirms Transplant Advantage Over RVD Alone with MRD as Key Discriminator The New England journal of medicine 2017 Landmark-class Integrating Liquid Biopsies into Cancer Management: A Clinical Roadmap for ctDNA Nature reviews. Clinical oncology 2017 Landmark-class Landmark Review Charts the Path from ctDNA Research to Clinical Liquid Biopsy Nature reviews. Cancer 2017 Landmark-class EuroFlow Standardised 8-Colour Flow Cytometry Achieves 10-5 MRD Sensitivity in B-Cell ALL Blood 2016 Landmark-class Cord-Blood Transplants Yield Lower Relapse Rates Than Unrelated Donors in MRD-Positive Leukemia The New England journal of medicine 2016 Landmark-class Molecular Testing Challenges in Advanced NSCLC: From EGFR to PDL1 and Beyond Lancet (London, England) 2016 Landmark-class PET/CT Combined With Flow Cytometry MRD Improves Prognostic Stratification in Myeloma After Daratumumab Blood 2025 Significance 7/10 Mass Spectrometry Poised to Replace Electrophoresis for M-Protein Detection in Clinical Labs Annals of laboratory medicine 2025 Significance 7/10 PSA Variability Is High: 22% of Elevated Results Normalise Within a Year JAMA oncology 2025 Significance 7/10 Review Positions ctDNA-Based MRD Monitoring as Key to Personalising Unresectable Stage III NSCLC Therapy Nature reviews. Clinical oncology 2025 Significance 7/10 Default Mailed FIT Kit Outperforms Active Choice Strategies for Colorectal Screening in Younger Adults JAMA 2025 Significance 7/10 High-Dose Aumolertinib Shows Durable CNS Response in EGFR-Mutant NSCLC With Brain Metastases JAMA oncology 2025 Significance 7/10 Comprehensive Review Frames MRD as a Powerful but Incompletely Standardised Biomarker Across Haematologic Malignancies EClinicalMedicine 2025 Significance 7/10 BrECADD Preserves Fertility Significantly Better Than eBEACOPP in Advanced Hodgkin Lymphoma The Lancet. Oncology 2025 Significance 7/10 Extended Ibrutinib-Venetoclax Schedule Achieves 53% Undetectable MRD in Relapsed CLL Blood 2025 Significance 7/10 EFLM Conference Maps New Frontiers in Preanalytical Quality -- From AI to Liquid Biopsy Challenges Clinical chemistry and laboratory medicine 2025 Significance 7/10 SCLC Heterogeneity and Phenotypic Plasticity Demand New Biomarker Strategies Nature reviews. Cancer 2025 Significance 7/10 Review Maps Opportunities and Barriers for MRD-Guided Treatment in Multiple Myeloma Nature reviews. Clinical oncology 2025 Significance 7/10 European Liquid Biopsy Society Issues Consensus Guidelines for ctDNA Test Reporting EBioMedicine 2025 Significance 7/10 Zanubrutinib-Venetoclax-Obinutuzumab Achieves 85% Undetectable MRD in Relapsed CLL Blood 2025 Significance 7/10 Multicenter AIEOP-BFM Study Standardizes Flow Cytometry MRD Assessment in Pediatric T-ALL Clinical chemistry and laboratory medicine 2025 Significance 7/10 Adding a Return Deadline to FIT Invitation Letters Boosts Colorectal Screening Uptake Lancet (London, England) 2025 Significance 7/10 Chemo-Free BOVen Triplet Meets Efficacy Endpoint in TP53-Mutant Mantle Cell Lymphoma Blood 2025 Significance 7/10 ctDNA in Early and Locally Advanced NSCLC: Evidence Review and Clinical Readiness Assessment Nature reviews. Clinical oncology 2025 Significance 7/10 Frontline Large B-Cell Lymphoma Trials Increasingly Leverage ctDNA for Response-Adapted Strategies Blood 2025 Significance 7/10 Precision Imaging in Oncology: Bridging the Gap Between Liquid Biopsy and Treatment Monitoring The Lancet. Oncology 2025 Significance 7/10 Oral SERD Camizestrant Outperforms Fulvestrant in ER-Positive Advanced Breast Cancer The Lancet. Oncology 2024 Significance 7/10 Beyond pCR: Residual Disease Biology and ctDNA Refine Post-Neoadjuvant Strategy in Breast Cancer JAMA oncology 2024 Significance 7/10 Tepotinib Plus Osimertinib Achieves 50% Response Rate in MET-Amplified EGFR-Mutant NSCLC (INSIGHT 2) The Lancet. Oncology 2024 Significance 7/10 PROSPER Trial: Perioperative Nivolumab Fails to Improve Recurrence-Free Survival in Renal Cell Carcinoma The Lancet. Oncology 2024 Significance 7/10 Multiomics Profiling of Circulating Tumor Cells Reveals Metastatic Biology and Clinical Potential Cancer discovery 2024 Significance 7/10 DESTINY-Gastric01 Biomarker Analysis Reveals ctDNA and HER2 Heterogeneity Challenges in Gastric Cancer Nature medicine 2024 Significance 7/10 Neoadjuvant Immunotherapy in Esophageal Cancer: ctDNA Clearance Reflects Neoantigen-Specific T Cell Responses Nature medicine 2024 Significance 7/10 Systematic Review of Multi-Cancer Early Detection Tests: High Specificity, Variable Sensitivity Across 20 Studies Clinical chemistry 2024 Significance 7/10 Blood-Based Biomarkers for Lung Cancer Screening: Proteins, miRNA, cfDNA, and Methylation Panels Reviewed Clinical chemistry 2024 Significance 7/10 Practical Guide to Interpreting ctDNA in Gastrointestinal Cancer Management Clinical chemistry 2024 Significance 7/10 Review Identifies Critical Preanalytical and Analytical Variables in ctDNA Liquid Biopsy Workflows Clinical chemistry 2024 Significance 7/10 Extracellular Vesicle Biomarker Assays: Roadmap from Discovery to Clinical Implementation Clinical chemistry 2024 Significance 7/10 Sorafenib Plus Chemotherapy Does Not Improve Event-Free Survival in FLT3-ITD AML, but MRD Clearance Predicts Benefit Blood 2023 Significance 7/10 AI-Driven Digital Pathology and ctDNA Converge to Personalise Adjuvant Therapy in Colorectal Cancer Nature reviews. Clinical oncology 2023 Significance 7/10 Review Envisions MRD as Future Coprimary Endpoint and Treatment Adaptation Tool in Myeloma Blood 2023 Significance 7/10 GIVe Triple Combination Achieves Durable Remissions in High-Risk CLL With del(17p)/TP53 Mutation Blood 2023 Significance 7/10 Tumor Treating Fields Plus Standard Therapy Improves Survival in Metastatic NSCLC (LUNAR Phase 3) The Lancet. Oncology 2023 Significance 7/10 HPV Testing in Urine, Blood and Oral Specimens Gains Ground for Cancer Screening and Surveillance Journal of clinical microbiology 2023 Significance 7/10 New Genomic and Liquid Biopsy Insights Illuminate Richter Syndrome Transformation Blood 2023 Significance 7/10 Cell-Free RNA Fragments Outperform Other cfRNA Types for Early Hepatocellular Carcinoma Detection EBioMedicine 2023 Significance 7/10 Cholangiocarcinoma: cfDNA Monitoring Emerges Alongside FGFR2 and IDH1 Targeted Therapies Nature reviews. Clinical oncology 2023 Significance 7/10 Modelling Analysis Finds Modest Efficiency Gains for Polygenic Risk Score-Stratified Cancer Screening in the UK The Lancet. Oncology 2023 Significance 7/10 Belzutifan Plus Cabozantinib Shows Promising Activity in Pretreated Clear Cell Renal Cell Carcinoma The Lancet. Oncology 2023 Significance 7/10 CLEAR Trial Extended Follow-Up Confirms Durable PFS Benefit of Lenvatinib-Pembrolizumab in Renal Cell Carcinoma The Lancet. Oncology 2023 Significance 7/10 ATLAS Trial: Carfilzomib-Lenalidomide-Dexamethasone Maintenance Extends Progression-Free Survival in Myeloma After Transplant The Lancet. Oncology 2023 Significance 7/10 Cytogenetic Risk Stratification Reveals Unmet Need in Ultra-High-Risk Myeloma Despite Carfilzomib-Based Therapy The Lancet. Oncology 2022 Significance 7/10 Circulating Tumour Cell Biology Reveals New Cancer Vulnerabilities and Liquid Biopsy Opportunities Nature reviews. Cancer 2022 Significance 7/10 Mutation Enrichment Technologies Advance Low-Frequency Variant Detection for Liquid Biopsy Clinical chemistry 2022 Significance 7/10 International Consensus Prioritizes Molecular Biomarkers for Risk Stratification in Ewing Sarcoma NPJ precision oncology 2022 Significance 7/10 Clinical Trial Design Evolves for the Precision Oncology Era Genome medicine 2022 Significance 7/10 Personalized Neoantigen Vaccine Shows Promise in MSS Colorectal Cancer with ctDNA Response Correlation Nature medicine 2022 Significance 7/10 Beyond Blood: ctDNA from Urine, CSF, and Body Fluids Offers Distinct Diagnostic Advantages Nature reviews. Clinical oncology 2022 Significance 7/10 Nano-Omics: Nanotechnology-Enabled Multi-Omics Analysis of the Blood-Circulating Cancerome Nature reviews. Clinical oncology 2022 Significance 7/10 TERT Promoter Mutations Present in 60-80% of Bladder Cancers, Detectable Via Liquid Biopsy Human pathology 2022 Significance 7/10 ERBB2-Positive Metastatic Colorectal Cancer: Diagnostic Methods and Emerging Targeted Therapies JAMA oncology 2022 Significance 7/10 Lynch Syndrome Carriers With MSH2/MSH6 Mutations Show Higher Prostate Cancer Rates in IMPACT Screening Study The Lancet. Oncology 2021 Significance 7/10 Tumour-Educated Platelets Emerge as a Novel Liquid Biopsy Platform for Early Cancer Detection Blood 2021 Significance 7/10 General Health Checks Do Not Reduce Mortality but Boost Chronic Disease Detection JAMA 2021 Significance 7/10 Circulating Mitochondrial DNA Identified as a Proinflammatory DAMP in Sickle Cell Disease Blood 2021 Significance 7/10 ctDNA-Based Pan-Cancer Screening Tests Achieve Over 99% Specificity but Sensitivity Remains Stage-Dependent Clinical chemistry and laboratory medicine 2021 Significance 7/10 TRACERx Review: Tracking Cancer Evolution from Primary Disease Through Recurrence via Multiregion Sequencing Cancer discovery 2021 Significance 7/10 Liquid Biopsy Matures: A Framework for CTC and ctDNA Clinical Applications Cancer discovery 2021 Significance 7/10 Biomarker-Targeted Therapy Landscape in Gastric Cancer Expands Beyond HER2, MSI and PD-L1 Nature reviews. Clinical oncology 2021 Significance 7/10 ESOPE Trial: Profiling First Metastatic Event in Breast Cancer Reveals Actionable Heterogeneity Genome medicine 2021 Significance 7/10 Cancer of Unknown Primary: Molecular Tissue-of-Origin Tests and NGS Enter the Diagnostic Workup BMJ (Clinical research ed.) 2020 Significance 7/10 Bladder Cancer Review Highlights Liquid Biopsy and MRD Advances Nature reviews. Cancer 2020 Significance 7/10 Early-Onset Colorectal Cancer: Rising Incidence Demands New Screening and Biomarker Strategies Nature reviews. Clinical oncology 2020 Significance 7/10 mRNA-1273 Vaccine Elicits Strong Neutralising Antibody Responses in Older Adults The New England journal of medicine 2020 Significance 7/10 Next-Generation Sequencing in Clinical Laboratory Medicine: A Comprehensive Review Annals of laboratory medicine 2020 Significance 7/10 ENVISION Consensus Calls for Personalized Breast Cancer Screening Based on Multi-Factor Risk Models Nature reviews. Clinical oncology 2020 Significance 7/10 Circulating Tumour Cells: From Metastatic Biology to Clinical Liquid Biopsy Applications Genome medicine 2020 Significance 7/10 Switch-Blocker PCR Platform Achieves 93-96% Concordance with Tissue Biopsy for EGFR, BRAF, and KRAS ctDNA Journal of clinical pathology 2020 Significance 7/10 Epigenomic Approaches for Cancer Detection Using Tissue and Cell-Free DNA Clinical chemistry 2020 Significance 7/10 Liquid Biopsy Enters the Phenotypic Era With Single-Cell CTC Profiling Clinical chemistry 2020 Significance 7/10 Plasma miRNA Extraction Method Strongly Influences Biomarker Discovery Results, Multicenter Study Warns Clinical chemistry 2019 Significance 7/10 IMWG Consensus Standardises Imaging for Bone Disease and MRD Detection in Myeloma The Lancet. Oncology 2019 Significance 7/10 Designing ctDNA-Based Interventional Clinical Trials: A Framework for Oncology Genome medicine 2019 Significance 7/10 ctDNA Screening Selects Patients for Successful Anti-EGFR Rechallenge in Colorectal Cancer JAMA oncology 2019 Significance 7/10 Circulating Tumour Cells in Prostate Cancer: From Enumeration to Precision Oncology Clinical chemistry 2019 Significance 7/10 CSF ctDNA Clearance Correlates with Sustained Response in CNS Lymphoma Combination Therapy Trial Blood 2018 Significance 7/10 Plasma DNA Analysis in Prostate Cancer: Opportunities Across the Disease Spectrum Clinical chemistry 2018 Significance 7/10 Molecular Biomarkers for Guiding Bladder Preservation Therapy in Muscle-Invasive Bladder Cancer The Lancet. Oncology 2018 Significance 7/10 EPA and aspirin fail to reduce colorectal adenoma rates in high-risk screening patients Lancet (London, England) 2018 Significance 7/10 Universal Cancer Screening Via Multi-Analyte Blood Tests: A Conceptual Framework NPJ precision oncology 2018 Significance 7/10 MRD Testing in CLL Evolves From Chemoimmunotherapy to Novel Targeted Agents JAMA oncology 2018 Significance 7/10 Triple BRAF/EGFR/MEK Inhibition Achieves 21% Response in BRAF V600E Colorectal Cancer with cfDNA Resistance Tracking Cancer discovery 2018 Significance 7/10 Leptomeningeal Metastases in NSCLC: Advances in CSF Liquid Biopsy and CNS-Penetrant Therapies The Lancet. Oncology 2018 Significance 7/10 Oncometabolites Bridge Inborn Errors of Metabolism and Cancer Diagnostics Clinical chemistry 2017 Significance 7/10 Colonoscopy outreach outperforms mailed FIT for completing cancer screening process JAMA 2017 Significance 7/10 EGFRvIII Vaccine Rindopepimut Fails to Improve Survival in Glioblastoma Despite MRD-Based Patient Selection The Lancet. Oncology 2017 Significance 7/10 High-Throughput Sequencing Enables Sensitive Noninvasive MRD Detection Across Hematologic Malignancies Blood 2017 Significance 7/10 IMWG Consensus Defines Role of PET/CT for MRD Assessment and Response Monitoring in Myeloma The Lancet. Oncology 2017 Significance 7/10 Technological Considerations for Clinical Cancer Genome Profiling: From FFPE to Liquid Biopsy Genome medicine 2016 Significance 7/10 Systematic review maps 788 blood-based biomarkers for early cancer detection EBioMedicine 2016 Significance 7/10 Enhanced reminder letters reduce socioeconomic gradient in bowel cancer screening uptake Lancet (London, England) 2015 Significance 7/10 Eliminating MRD as a Therapeutic Endpoint Could Move CLL Treatment Toward Cure Blood 2015 Significance 7/10 Liquid Biopsy Meets Mutational Signatures: A Framework for Longitudinal Cancer Monitoring NPJ precision oncology 2026 Significance 6/10 Review Highlights ctDNA as a Promising Risk Stratification Tool in Marginal Zone Lymphoma Blood 2026 Significance 6/10 Follicular Lymphoma Review Envisions ctDNA Replacing Imaging for Treatment Monitoring Blood 2025 Significance 6/10 Emerging Molecular Targets in Breast Cancer: From NGS and Liquid Biopsy to Spatial Transcriptomics Human pathology 2025 Significance 6/10 Comprehensive Review Maps ctDNA Treatment Monitoring Across Lung, Colorectal, and Breast Cancer NPJ precision oncology 2025 Significance 6/10 Expert Review Redefines ETP-ALL Management with MRD-Guided Risk Stratification Blood 2025 Significance 6/10 Review Examines MRD Monitoring and Molecular Biomarkers for Risk Stratification in Peripheral T-Cell Lymphoma Blood 2024 Significance 6/10 Expert Framework Calls for Standardized Neoadjuvant Biopsy Trials in Glioma Drug Development The Lancet. Oncology 2024 Significance 6/10 Comprehensive Review Maps Liquid Biopsy Landscape Across Pediatric Solid Tumors NPJ precision oncology 2024 Significance 6/10 Liquid Biopsy with miRNA and ctDNA Shows Promise for Gastric Cancer Screening and Treatment Monitoring Clinical biochemistry 2024 Significance 6/10 Circulating Tumour Cells in Breast Cancer: Current Clinical Validity and Emerging Utility Clinical chemistry 2024 Significance 6/10 Circulating Tumor Cells: From Metastatic Biology to Precision Medicine Applications Clinical chemistry 2024 Significance 6/10 ctDNA Implementation Challenges: From Early Detection to Immunotherapy Monitoring Clinical chemistry and laboratory medicine 2023 Significance 6/10 Global Lung Cancer Burden Underscores Need for Expanded Low-Dose CT Screening Programs Nature reviews. Clinical oncology 2023 Significance 6/10 Lucerne Toolbox 2: European Consensus on Axillary Lymph Node Management in Early Breast Cancer EClinicalMedicine 2023 Significance 6/10 Review Charts Genomic and Epigenetic Advances Transforming Oesophageal Cancer Detection and Treatment Nature reviews. Clinical oncology 2023 Significance 6/10 Urinary Cell-Free DNA Emerges as Truly Non-Invasive Alternative for Cancer Liquid Biopsy Clinical chemistry 2022 Significance 6/10 Women Disadvantaged in FIT-Based Colorectal Screening Due to Lower Faecal Haemoglobin Concentrations Clinical chemistry and laboratory medicine 2022 Significance 6/10 Circulating lncRNAs as Blood-Based Cancer Biomarkers: Diagnostic Performance and NGS Methods NPJ precision oncology 2022 Significance 6/10 Precision Diagnostics for Advanced Cutaneous Squamous Cell Carcinoma: Liquid Biopsy and Molecular Profiling NPJ precision oncology 2022 Significance 6/10 Circular RNAs Emerge as Cancer Biomarkers Detectable in Liquid Biopsy Nature reviews. Clinical oncology 2021 Significance 6/10 Tumor-Educated Platelets Emerge as Novel Liquid Biopsy Source for Cancer RNA Biomarkers Blood 2021 Significance 6/10 International consensus provides clinical toolbox for breast surgery after neoadjuvant therapy The Lancet. Oncology 2021 Significance 6/10 NGS and Flow Cytometry Reshape Treatment Paradigms in Acute Myeloid Leukemia Clinical pharmacology and therapeutics 2020 Significance 6/10 Circulating Tumour DNA in Molecular Oncology: Clinical Applications and Pre-Analytical Considerations Clinical chemistry and laboratory medicine 2020 Significance 6/10 Single-Cell Profiling of Circulating Tumour Cells Advances Liquid Biopsy Beyond Bulk Analysis NPJ precision oncology 2019 Significance 6/10 Pilot Ring Trial for Plasma ctDNA EGFR Mutation Testing Using Cobas Platform Clinical chemistry and laboratory medicine 2019 Significance 6/10 Tumor-Educated Platelets Emerge as a Distinct Liquid Biopsy Analyte Blood 2019 Significance 6/10 Circulating Tumor DNA as a Cancer Biomarker: Advantages Over Tissue and Protein Markers Annals of clinical biochemistry 2018 Significance 6/10 GSTP1 Methylation as a Liquid Biopsy Biomarker: Systematic Review Across Cancer Types Clinical chemistry and laboratory medicine 2018 Significance 6/10 Cell-Free DNA Across Body Fluids: Clinical Applications and Preanalytical Considerations for Molecular Pathology The Journal of pathology 2018 Significance 6/10 Cell-Free DNA Assays Move From Research to Routine Clinical Oncology Annals of laboratory medicine 2018 Significance 6/10 Translating Epigenetic Biomarkers From Discovery to Clinical Diagnostics: Challenges and Strategies Clinical chemistry and laboratory medicine 2017 Significance 6/10 Immunophenotypic and Genetic Profiling Essential for Risk Stratification in Adult T-Cell ALL Blood 2017 Significance 6/10 TIMPs as Extracellular Regulators of Cancer: From Tumour Biology to Liquid Biopsy Biomarkers Nature reviews. Cancer 2016 Significance 6/10 Circulating MicroRNAs as Blood-Based Cancer Biomarkers: Diagnostic and Screening Potential EBioMedicine 2016 Significance 6/10 Circulating Tumour Cell Isolation Technologies: From Biomarker-Dependent to Charge-Based Capture EBioMedicine 2022 Significance 5/10 Evidence on Repeat FIT Testing in Symptomatic Patients Remains Minimal and Conflicting Annals of clinical biochemistry 2022 Significance 5/10 Diabetes Lowers PSA Levels but the Difference Is Too Small to Affect Cancer Detection Clinical chemistry and laboratory medicine 2020 Significance 5/10 Patient-specific physician alerts modestly boost colorectal cancer screening uptake JAMA 2020 Significance 5/10 Liquid Biopsy in Gastrointestinal Cancer: From CTCs to ctDNA and Extracellular Vesicles Clinical biochemistry 2020 Significance 5/10 Caribbean Cancer Control Hampered by Weak Surveillance, Limited Diagnostics, and Advanced-Stage Presentations The Lancet. Oncology 2019 Significance 5/10 Pacific Island Nations Face Triple Cancer Burden With Fragmented Screening and Pathology Services The Lancet. Oncology 2019 Significance 5/10 GP notification of non-adherent patients increases FIT screening participation JAMA 2017 Significance 5/10 Whole-exome sequencing identifies PTEN hamartoma syndrome behind colorectal polyps Diagnostic pathology 2023 Significance 4/10

Five-Year ZUMA-1 Follow-Up: 43% of Refractory Lymphoma Patients Alive After Axi-cel CAR T Therapy Blood 2023 Landmark-class Large Individual Patient Data Analysis Quantifies the Prognostic Cost of p16/HPV Discordance in Oropharyngeal Cancer The Lancet. Oncology 2023 Landmark-class Non-Viral CRISPR-Edited Neoantigen-Specific T Cells Traffic to Tumours in First-in-Human Solid Cancer Trial Nature 2022 Landmark-class POC Nucleic Acid Testing Dramatically Accelerates HIV Treatment in Infants Lancet (London, England) 2022 Landmark-class NEJM Trial: Decentralised On-Site Molecular TB Testing Increases Diagnosis and Same-Day Treatment The New England journal of medicine 2021 Landmark-class Cilta-cel CAR T-Cell Therapy Achieves 97% Response Rate in Heavily Pretreated Multiple Myeloma Lancet (London, England) 2021 Landmark-class First-in-Human Trial of Multiplex CRISPR-Cas9 Edited T Cells Shows Safety and Durable Engraftment in Cancer Science (New York, N.Y.) 2020 Landmark-class NEJM PACE Trial: CRP Point-of-Care Testing Safely Cuts Antibiotic Prescribing in COPD Exacerbations The New England journal of medicine 2019 Landmark-class CRISPR-Cas Systems: From Genome Editing to Programmable Diagnostics Science (New York, N.Y.) 2018 Landmark-class IFCC Framework for Implementing High-Sensitivity Cardiac Troponin Point-of-Care Testing in Acute Care Settings Clinical chemistry and laboratory medicine 2026 Landmark-class Obicetrapib Lowers LDL-C by 36% in Familial Hypercholesterolaemia: BROOKLYN Trial Results Nature medicine 2026 Landmark-class CASTLE Basket Trial: CD19 CAR-T Achieves Remission Across Three Autoimmune Diseases Nature medicine 2026 Landmark-class Permethrin-Treated Baby Wraps Cut Childhood Malaria Incidence by 66% in Ugandan RCT The New England journal of medicine 2025 Landmark-class PCSK9 Inhibition Does Not Prevent Saphenous Vein Graft Failure After CABG Despite Halving LDL Cholesterol Lancet (London, England) 2025 Landmark-class Lorundrostat, a Novel Aldosterone Synthase Inhibitor, Significantly Lowers Blood Pressure in Phase 3 Trial JAMA 2025 Landmark-class Somatic Mosaicism Network Maps Mutations Across 19 Tissue Types to Build a Human Reference Catalogue Nature 2025 Landmark-class ISUP Consensus Refines Reporting Standards for Prostate Cancer Precursor Lesions The American journal of surgical pathology 2025 Landmark-class Lancet Phase 3 TANDEM Trial: Obicetrapib-Ezetimibe Combination Cuts LDL Cholesterol by 49% Lancet (London, England) 2025 Landmark-class First-in-Human CRISPR Knockout of Intracellular Checkpoint CISH in TIL Therapy for Colorectal Cancer The Lancet. Oncology 2025 Landmark-class Systematic Review: Professional-Use Glucometers Meet ISO 15197 Accuracy Standards, but Home-Use Devices Fall Short Clinical biochemistry 2025 Landmark-class High-Sensitivity Cardiac Troponin: From Subclinical Risk to POC Emergency Diagnostics Clinical chemistry and laboratory medicine 2025 Landmark-class Tucatinib-Trastuzumab Shows 42% Response Rate in HER2-Mutated, HER2-Negative Breast Cancer Nature medicine 2025 Landmark-class Point-of-Care Testing Cuts Emergency Department Decision Time by 75 Minutes in Multicentre RCT Clinical chemistry and laboratory medicine 2024 Landmark-class RSV in Children: Molecular POC Testing and New Prevention Strategies Reshape Clinical Management Lancet (London, England) 2024 Landmark-class High-Sensitivity Troponin I Point-of-Care Assay Matches Lab Performance in MI Rule-Out Protocols Clinical chemistry and laboratory medicine 2024 Landmark-class Seven-Year Follow-Up Confirms Durable Remissions with Venetoclax-Ibrutinib in Mantle Cell Lymphoma Blood 2024 Landmark-class PROMISE-EPI: POC Viral Load-Guided Infant Prophylaxis Reduces Postnatal HIV Transmission Lancet (London, England) 2024 Landmark-class Adding Dihydroartemisinin-Piperaquine to Co-trimoxazole Cuts Malaria Risk by 55% in Pregnant Women Living With HIV Lancet (London, England) 2024 Landmark-class Divarasib Plus Cetuximab Achieves 63% Response Rate in KRAS G12C-Positive Colorectal Cancer Nature medicine 2023 Landmark-class Phase 2 Trial: Chemo-Immunotherapy Enables Bladder Sparing in 43% of Muscle-Invasive Bladder Cancer Patients Nature medicine 2023 Landmark-class Prophylactic Anakinra Reduces Severe Neurotoxicity to Under 10% in CAR T-Cell Therapy for Lymphoma Nature medicine 2023 Landmark-class Camonsertib ATR Inhibitor Shows Activity in DDR-Deficient Solid Tumours Guided by Genomic Biomarkers Nature medicine 2023 Landmark-class NEJM Trial Shows Point-of-Care Ultrasound Is Non-Inferior to Radiography for Paediatric Forearm Fractures The New England journal of medicine 2023 Landmark-class CRISPR in Cancer: From Functional Genomics to Diagnostics and Therapeutics Nature reviews. Cancer 2022 Landmark-class NEJM Review Establishes Point-of-Care Ultrasound as Essential Bedside Diagnostic Tool The New England journal of medicine 2021 Landmark-class Procalcitonin Point-of-Care Testing Reduces Antibiotic Prescribing by 26% for Lower Respiratory Tract Infections in Primary Care BMJ (Clinical research ed.) 2021 Landmark-class CRP Point-of-Care Testing Safely Reduces Antibiotic Prescribing by 29% in Nursing Home Residents With Respiratory Infections BMJ (Clinical research ed.) 2021 Landmark-class Tisagenlecleucel Demonstrates Durable Responses at 40-Month Follow-Up in Aggressive B-Cell Lymphoma The Lancet. Oncology 2021 Landmark-class Teclistamab Bispecific Antibody Shows 65% Response Rate in Heavily Pretreated Multiple Myeloma Lancet (London, England) 2021 Landmark-class Emicizumab Maintains Low Bleed Rates Through Three Years in Haemophilia A: Pooled HAVEN 1-4 Data Blood 2021 Landmark-class Synthetic Lethality Emerges as Next-Generation Strategy for Targeting Undruggable Cancer Mutations Cancer discovery 2021 Landmark-class Konica Minolta Validates a High-Sensitivity Point-of-Care Cardiac Troponin I System Clinical chemistry and laboratory medicine 2019 Landmark-class VIVO Method Validates CRISPR In Vivo Editing with No Detectable Off-Target Mutations Nature 2018 Landmark-class Meta-Analysis Confirms Strong Performance of Xpert HIV-1 Viral Load at Point of Care Journal of clinical microbiology 2018 Landmark-class NEJM Study: Point-of-Care Hemostasis Test Detects Aortic Regurgitation During TAVR in Real Time The New England journal of medicine 2016 Landmark-class Seven-Gene Transcriptomic Score Quantifies Immune Dysregulation in Sepsis on a Point-of-Care Platform EBioMedicine 2016 Landmark-class Early Relapse Within 12 Months Predicts Poor Survival in Nodal Mature T-Cell Lymphomas Blood 2026 Significance 7/10 Fingerstick Hepatitis B DNA Testing with Xpert Assay Enables Decentralised Viral Load Monitoring Journal of clinical microbiology 2026 Significance 7/10 Cobas Liat POC NAAT Delivers Lab-Grade STI Detection for Chlamydia, Gonorrhoea, and M. genitalium in 20 Minutes Journal of clinical microbiology 2025 Significance 7/10 International Consensus on Pathological Response Assessment After Neoadjuvant Therapy in Renal Cell Carcinoma The Lancet. Oncology 2025 Significance 7/10 Lancet Review Frames Heart Failure Prevention Within Cardiovascular-Kidney-Metabolic Health Lancet (London, England) 2025 Significance 7/10 Checkpoint Inhibitor Exposure Before Allogeneic Transplant Improves PFS in Hodgkin Lymphoma Blood 2025 Significance 7/10 CONTACT-02 Final Analysis: Cabozantinib-Atezolizumab Improves PFS but Not OS in mCRPC with Soft-Tissue Metastases The Lancet. Oncology 2025 Significance 7/10 Acute Rheumatic Fever: Molecular POC Tests and Biomarker Discovery Could Transform Diagnostics Lancet (London, England) 2025 Significance 7/10 TALAPRO-2 HRR-Deficient Cohort: PARP-AR Combination Delays Symptom Deterioration in Biomarker-Selected mCRPC The Lancet. Oncology 2025 Significance 7/10 Solbinsiran siRNA Targeting ANGPTL3 Reduces ApoB in Mixed Dyslipidaemia: Phase 2 Results Lancet (London, England) 2025 Significance 7/10 Cas12 and TnpB Variants: Expanding the CRISPR Toolkit for Editing and Diagnostics Nature biotechnology 2024 Significance 7/10 Large Prospective Study Leads to FDA Clearance of Cepheid Xpert Xpress CoV-2 Plus Journal of clinical microbiology 2024 Significance 7/10 Treatment Landscape for Nodal Peripheral T-Cell Lymphomas Moving Toward Biomarker-Driven Subtype-Specific Therapy Blood 2024 Significance 7/10 Valemetostat Dual EZH Inhibitor Shows 55% Response Rate in Relapsed Non-Hodgkin Lymphoma The Lancet. Oncology 2024 Significance 7/10 TiNivo-2 Trial: ICI Rechallenge Fails to Improve PFS in Post-Checkpoint Renal Cell Carcinoma Lancet (London, England) 2024 Significance 7/10 Phase 1 Trial: Live Bacterial Supplementation Boosts Response Rate to Cabozantinib-Nivolumab in Kidney Cancer Nature medicine 2024 Significance 7/10 CAR-T Outcomes Vary by Race and Ethnicity: Real-World Data from 1,290 LBCL Patients Blood 2024 Significance 7/10 ELARA Update: Tisagenlecleucel Shows Durable Responses at 29 Months in Relapsed Follicular Lymphoma Blood 2024 Significance 7/10 SARS-CoV-2 Testing Four Years On: Lessons Learned and Current Use Cases Clinical microbiology reviews 2024 Significance 7/10 Systematic Review Finds Health Inequality Impacts Largely Ignored in Antimicrobial Stewardship Interventions Lancet (London, England) 2023 Significance 7/10 Lancet RCT: Intravenous Ferric Carboxymaltose Did Not Reduce Anaemia at 36 Weeks in Malawian Pregnancies Lancet (London, England) 2023 Significance 7/10 AI-Powered Point-of-Care Testing: Transforming Lateral Flow, Microscopy, and Haematology Annals of laboratory medicine 2023 Significance 7/10 AI and Machine Learning Are Reshaping Infectious Disease Diagnostics Clinical chemistry 2021 Significance 7/10 Lateral Flow Assays: Technology Advances Drive New Era in Infectious Disease Diagnostics Clinical chemistry 2021 Significance 7/10 Whole-Exome Sequencing Reveals Ciliary Gene Mutations in 31% of Nonsyndromic Biliary Atresia Cases EBioMedicine 2021 Significance 7/10 Point-of-Care Placental Growth Factor Testing Does Not Reduce Maternal Morbidity in Suspected Pre-eclampsia: PARROT Ireland Trial BMJ (Clinical research ed.) 2021 Significance 7/10 SARS-CoV-2 Antigen Rapid Tests Show High False-Positive Rates When Screening Asymptomatic Healthcare Workers Journal of clinical microbiology 2021 Significance 7/10 Monthly Dihydroartemisinin-Piperaquine Outperforms Sulfadoxine-Pyrimethamine for Malaria Prevention in Pregnancy in Tanzania Clinical pharmacology and therapeutics 2021 Significance 7/10 Ultrasensitive Diagnostics Target the Hidden Reservoir of Asymptomatic Malaria Journal of clinical microbiology 2021 Significance 7/10 CRISPR Genome Editing Advances Next-Generation Adoptive Cell Therapies for Cancer Cancer discovery 2021 Significance 7/10 Beyond Cytokine Storm: Subacute Toxicities and Long-Term Monitoring Needs in Paediatric CAR-T Nature reviews. Clinical oncology 2021 Significance 7/10 KRd Plus Transplant Achieves 70% MRD Negativity in Newly Diagnosed Multiple Myeloma Blood 2020 Significance 7/10 Neoadjuvant Durvalumab Plus Tremelimumab Achieves 37.5% Pathological Complete Response in High-Risk Urothelial Carcinoma Nature medicine 2020 Significance 7/10 Practical Guide to Verifying EUA Molecular Assays for SARS-CoV-2 Detection Journal of clinical microbiology 2020 Significance 7/10 In Vivo Functional Genomic Screens: CRISPR, Transposons, and RNAi for Cancer Gene Discovery Nature reviews. Cancer 2020 Significance 7/10 COVID-19 Diagnostic Landscape: From RT-PCR to Point-of-Care and Serological Tests Journal of clinical pathology 2020 Significance 7/10 Molecular POC Testing in Microbiology: Matching Lab Sensitivity at the Bedside Clinical chemistry 2020 Significance 7/10 Faecal Calprotectin in IBD: Meta-Analyses Reveal Strengths and Assay Interchangeability Problems Clinical chemistry and laboratory medicine 2019 Significance 7/10 Point-of-Care HIV Viral Load Testing: Essential for Sustainable Global Treatment Targets Clinical microbiology reviews 2019 Significance 7/10 CRISPR-Cas as a Versatile Platform for Cancer Research, Screening, and Therapeutic Development Nature reviews. Clinical oncology 2019 Significance 7/10 CRISPR-Cas Biology and Emerging Applications in Infectious Disease Diagnostics and Therapeutics Journal of clinical microbiology 2019 Significance 7/10 Cryptococcal Antigen Lateral Flow Assay Enables Pre-Symptomatic Screening in HIV Patients Journal of clinical microbiology 2019 Significance 7/10 HIV Diagnostics: From Serologic Assays to Molecular POC Testing for Epidemic Control Clinical microbiology reviews 2018 Significance 7/10 Point-of-Care HbA1c Device Matches Lab Methods for Diabetes Diagnosis Clinical biochemistry 2018 Significance 7/10 Hcp1-Based Rapid Immunochromatography Test Offers Improved Point-of-Care Diagnosis of Melioidosis Journal of clinical microbiology 2018 Significance 7/10 Point-of-Care Troponin I Test Shows Diagnostic Promise for Acute MI in Emergency Settings Clinical chemistry and laboratory medicine 2018 Significance 7/10 Point-of-Care Testing Trends: From Wearables and Microfluidics to Mass Spectrometry Clinical chemistry 2018 Significance 7/10 Meta-Analysis: POC Natriuretic Peptide Tests Show High Sensitivity for Heart Failure but Need Primary Care Validation BMJ (Clinical research ed.) 2018 Significance 7/10 CRISPR-Cas Systems as Rapid Nucleic Acid Detection Tools for Pathogen Diagnostics Genome medicine 2018 Significance 7/10 Cepheid Xpert Flu+RSV Rapid PCR Assay Validated for CLIA-Waived Point-of-Care Settings Journal of clinical microbiology 2018 Significance 7/10 Cobas h232 Point-of-Care NT-proBNP Test Proves Accurate and Practice-Changing in Primary Care Heart Failure Workup Journal of clinical pathology 2017 Significance 7/10 AQT90 FLEX Point-of-Care Troponin I Matches Central Lab Performance, but Troponin T Falls Short Clinical biochemistry 2017 Significance 7/10 Pivotal Trial Validates a Non-Invasive Urine-Based Malaria Rapid Diagnostic Test Journal of clinical microbiology 2016 Significance 7/10 Mass Mosquito Trapping With Odour-Baited Solar Traps Reduces Malaria Prevalence by 30% in Stepped-Wedge Trial Lancet (London, England) 2016 Significance 7/10 Point-of-Care Procalcitonin Test Matches Central Lab Accuracy with Two-Hour Faster Turnaround Clinical chemistry and laboratory medicine 2016 Significance 7/10 Biomarker-Based POC Tests for Preeclampsia Could Transform Maternal Care in Low-Resource Settings Clinical chemistry and laboratory medicine 2016 Significance 7/10 Capillary Blood Sampling for Core Laboratories: Promise, Standardisation Gaps, and the Path Forward Clinical chemistry and laboratory medicine 2025 Significance 6/10 CYCLONE 2: CDK4/6 Inhibitor Abemaciclib Plus Abiraterone Does Not Improve PFS in mCRPC The Lancet. Oncology 2025 Significance 6/10 Cobas Liat POC RT-PCR for SARS-CoV-2 and Influenza Shows Over 98% Agreement with Central Lab Testing Journal of clinical microbiology 2025 Significance 6/10 TALAPRO-2 All-Comers: Talazoparib-Enzalutamide Preserves Quality of Life in mCRPC The Lancet. Oncology 2025 Significance 6/10 Cardiac MRI Shows Myocardial Fibrosis Reversal After Stem Cell Transplant in Young Sickle Cell Patients Blood 2024 Significance 6/10 At-Home Respiratory Virus Testing: Regulatory Landscape and Performance After the Pandemic Journal of clinical microbiology 2024 Significance 6/10 Pembrolizumab Maintenance After Autologous Transplant Shows Promise in T-Cell Lymphoma Blood 2023 Significance 6/10 Why CRP Remains the Most Requested Biomarker in Clinical Laboratories Clinical chemistry and laboratory medicine 2023 Significance 6/10 HbA1c and Diabetes Biomarkers: A Decade of Analytical and Clinical Progress Clinical chemistry and laboratory medicine 2022 Significance 6/10 Expert Guidelines Established for COVID-19 Molecular Testing in Mobile Laboratories Annals of laboratory medicine 2022 Significance 6/10 ASM Clinical Microbiology Open: Charting the Future of Diagnostics From NGS to AI Journal of clinical microbiology 2022 Significance 6/10 Flu@home Trial Tests At-Home Influenza RDTs With App-Based Symptom Triggers Journal of clinical microbiology 2022 Significance 6/10 Canadian Consensus Guidance for SARS-CoV-2 Point-of-Care Test Selection and Quality Management Clinical biochemistry 2021 Significance 6/10 CRISPR-Based SARS-CoV-2 Diagnostics: Rapid Alternatives to RT-qPCR Clinical biochemistry 2021 Significance 6/10 CSCC Publishes Quality Assurance Recommendations for Hospital and Community POCT Programmes Clinical biochemistry 2020 Significance 6/10 Molecular Point-of-Care Tests Challenge Culture-Based Strep A Diagnosis in Pediatrics Journal of clinical microbiology 2020 Significance 6/10 Comprehensive Review of Host-Directed Antiviral Therapy and CRISPR-Based Target Discovery Clinical microbiology reviews 2020 Significance 6/10 Diagnostic Strategies for Differentiating Cellulitis From Other Causes of Red Legs in Primary Care BMJ (Clinical research ed.) 2020 Significance 6/10 Multicenter Study Validates Cobas CRP Point-of-Care Test for Primary Care Use Clinical biochemistry 2019 Significance 6/10 DNA Writers and Molecular Recorders: Emerging Tools for In Vivo Genetic Information Processing Science (New York, N.Y.) 2018 Significance 6/10 Alere i RSV Assay Delivers 98.6% Sensitivity in Under 13 Minutes at Point of Care Journal of clinical microbiology 2018 Significance 6/10 Canadian Society of Clinical Chemists Issues Consensus Position on Point-of-Care Testing Clinical biochemistry 2018 Significance 6/10 Rapid Diagnostic Test for Second-Stage Sleeping Sickness Shows 100% Sensitivity in Field Study EBioMedicine 2017 Significance 6/10 Dengue Point-of-Care Diagnostics: Progress Toward Multiplexed Rapid Testing Journal of clinical microbiology 2017 Significance 6/10 POC Diagnostics for Infectious Disease: From Lateral Flow to Molecular Platforms Journal of clinical microbiology 2017 Significance 6/10 INR Point-of-Care Testing: Cost-Effective Self-Monitoring for Anticoagulation Therapy Clinical chemistry and laboratory medicine 2017 Significance 6/10 Review Maps the Case for Enhanced Point-of-Care Diagnostics in Deep Space Missions Clinical chemistry and laboratory medicine 2025 Significance 5/10 POC Glucose Metre Matches Blood Gas Analyser Accuracy Across All Neonatal Gestational Ages Annals of clinical biochemistry 2025 Significance 5/10 Over-the-Counter Strep A Testing: Opportunities and Challenges for Consumer Diagnostics Clinical biochemistry 2022 Significance 5/10 Prone Positioning Shows No Benefit for Non-Critically Ill Hospitalised COVID-19 Patients BMJ (Clinical research ed.) 2022 Significance 5/10 Single-Fraction SABR Non-Inferior to Multifraction for Pulmonary Oligometastases in Phase 2 Trial JAMA oncology 2021 Significance 5/10 Poloxamer 188 Fails to Shorten Vaso-Occlusive Episodes in Sickle Cell Disease JAMA 2021 Significance 5/10 Six-Year Review of Rickettsial Isolation from Blood Using Mammalian Cell Culture in Laos Journal of clinical microbiology 2020 Significance 5/10 Systematic Review Exposes Gaps in Statistical Methods for Paediatric Reference Intervals Clinical biochemistry 2020 Significance 5/10 Pharmacy-Based CLIA-Waived Testing Programmes for Infectious Disease Management Journal of clinical microbiology 2020 Significance 5/10 Three Generations of POC INR Devices Compared Across Extended Anticoagulation Ranges Journal of clinical pathology 2019 Significance 5/10 Alpha-Defensin POC Test for Prosthetic Joint Infection Needs Laboratory Oversight Clinical chemistry and laboratory medicine 2017 Significance 5/10 Preanalytical Factors Affect HemoCue Hemoglobin Measurements Differently Between Models Clinical biochemistry 2017 Significance 5/10 Genetics and Pathology Convergence: Integrating Genomic Analysis with Disease Mechanism Understanding The Journal of pathology 2017 Significance 5/10 CRISPR-Engineered Pig Models for Neurodegenerative Disease Research The Journal of pathology 2015 Significance 5/10 SHERLOCK and DETECTR: CRISPR-Cas Diagnostics for Rapid Infectious Disease Detection Journal of clinical microbiology 2021 Significance 4/10

AI-Guided Screening with Digital Stethoscope Doubles Detection of Peripartum Cardiomyopathy Nature medicine 2024 Landmark-class AI-Guided Triage to Supplemental MRI Detects Cancers Missed by Mammography at Four Times the Efficiency Nature medicine 2024 Landmark-class AI Outperforms Radiologists in Detecting Clinically Significant Prostate Cancer on MRI The Lancet. Oncology 2024 Landmark-class ORFAN Study: AI-Enhanced Coronary Inflammation Score Predicts Cardiac Events in Patients Without Obstructive CAD Lancet (London, England) 2024 Landmark-class Deep Learning Enables 10x MRI Acceleration While Preserving Oncological Biomarker Accuracy The Lancet. Oncology 2024 Landmark-class Biased AI Models Reduce Clinician Diagnostic Accuracy, and Explanations Do Not Mitigate the Harm JAMA 2023 Landmark-class PANDA: Deep Learning Detects Pancreatic Cancer on Non-Contrast CT With 92.9% Sensitivity Nature medicine 2023 Landmark-class MASAI Trial: AI-Supported Mammography Screening Matches Radiologist Accuracy While Cutting Workload by 44% The Lancet. Oncology 2023 Landmark-class Generalist Medical AI: A New Paradigm for Multimodal Clinical Foundation Models Nature 2023 Landmark-class Blinded RCT: AI Cardiac Function Assessment Proves Non-Inferior to Sonographers Nature 2023 Landmark-class DeepGlioma: AI-Based Rapid Molecular Classification of Brain Tumours in Under 90 Seconds Nature medicine 2023 Landmark-class AI-Guided ECG Screening Increases Atrial Fibrillation Detection Fivefold in High-Risk Patients Lancet (London, England) 2022 Landmark-class Early Cancer Detection: Toward Risk-Stratified, Multi-Modal Screening Paradigms Nature medicine 2022 Landmark-class AI-Enabled ECG Screening Increases Early Diagnosis of Low Ejection Fraction in Primary Care Nature medicine 2021 Landmark-class EchoNet-Dynamic: Video-Based Deep Learning Outperforms Experts in Cardiac Function Assessment Nature 2020 Landmark-class AI-Enabled ECG Detects Atrial Fibrillation During Sinus Rhythm: Landmark Mayo Clinic Validation Lancet (London, England) 2019 Landmark-class Landmark Pivotal Study: Whole-Slide Imaging Is Non-Inferior to Microscopy for Primary Surgical Pathology Diagnosis The American journal of surgical pathology 2018 Landmark-class Deep Learning Matches Dermatologist Accuracy in Skin Cancer Classification From Clinical Images Nature 2017 Landmark-class Deep Learning Achieves 0.99 AUC for Automated Diabetic Retinopathy Detection in Fundus Photographs JAMA 2016 Landmark-class AI-Led Diabetes Prevention Programme Matches Human Coaching in Phase 3 RCT JAMA 2025 Landmark-class Distant Disease-Free Survival Validated as Surrogate for Overall Survival in Neoadjuvant Breast Cancer Trials The Lancet. Oncology 2025 Landmark-class Comprehensive Review Maps EGFR TKI Resistance Mechanisms and ctDNA-Guided Adaptive Strategies in Lung Cancer Nature reviews. Clinical oncology 2025 Landmark-class Extracellular Vesicles as Cancer Diagnostics and Therapeutics: Clinical Translation Review Nature reviews. Clinical oncology 2025 Landmark-class Multimodal Eyecare Foundation Model Improves Diagnostic Accuracy in Randomized Controlled Trial Nature medicine 2025 Landmark-class PanEcho: AI System Achieves Complete Echocardiography Interpretation Across 39 Measurements JAMA 2025 Landmark-class GRAPE: Deep Learning Enables Large-Scale Gastric Cancer Screening From Non-Contrast CT Nature medicine 2025 Landmark-class MicroRNA-Based Risk Score Stratifies Type 1 Diabetes Risk Across Global Populations Nature medicine 2025 Landmark-class Multiomics Tumour Profiling Guides Personalized Melanoma Treatment in Prospective TuPro Study Nature medicine 2025 Landmark-class Reinforcement Learning Model Recommends Earlier Vasopressin in Septic Shock, Associated With Reduced Mortality JAMA 2025 Landmark-class Digital Pathology AI Faces a Reality Check: Progress and Barriers to Clinical Adoption Nature reviews. Clinical oncology 2025 Landmark-class Deep Learning from H&E Slides Predicts Immunotherapy Response in Advanced NSCLC JAMA oncology 2025 Landmark-class TRIPOD-LLM: First Reporting Guideline for Large Language Models in Healthcare Research Nature medicine 2025 Landmark-class AI-Driven Ultrasound Outperforms Expert Examiners in Ovarian Cancer Detection Across 20 Centers Nature medicine 2025 Landmark-class Deep Learning for Tumour Purity Estimation Outperforms Pathologist Review and Molecular Deconvolution in Colorectal Cancer The Journal of pathology 2024 Landmark-class AI-Based Pathology Tool Validated for MASH Scoring in Clinical Trials Nature medicine 2024 Landmark-class AI-RANO Part 2: Standardisation and Validation Recommendations for AI in Neuro-Oncology Response Assessment The Lancet. Oncology 2024 Landmark-class AI-RANO Part 1: AI for Diagnosis, Prediction and Response Assessment in Neuro-Oncology The Lancet. Oncology 2024 Landmark-class Medical AI and Human Values: Navigating Ethics, Equity, and Trust in Clinical Deployment The New England journal of medicine 2024 Landmark-class Multiplex Immune Profiling of Tumors: Translational Framework from the International Immuno-Oncology Biomarker Working Group The Journal of pathology 2024 Landmark-class INSPIRES Trial: Dual Antiplatelet Therapy Effective Up to 72 Hours After Ischaemic Stroke The New England journal of medicine 2023 Landmark-class AI-Derived Biomarker From Deep Brain Stimulation Tracks Depression Recovery in Real Time Nature 2023 Landmark-class AI Against Infectious Disease: Accelerating Diagnostics, Drug Discovery, and AMR Surveillance Science (New York, N.Y.) 2023 Landmark-class NEJM Review: The Current and Future State of AI Interpretation of Medical Images The New England journal of medicine 2023 Landmark-class Triplet vs Doublet Therapy in Metastatic Prostate Cancer: Living Network Meta-Analysis Finds Equipoise JAMA oncology 2023 Landmark-class AI Model Detects Lymph Node Metastases in Bladder Cancer with 98% Sensitivity, Including Missed Micrometastases The Lancet. Oncology 2023 Landmark-class Lung Cancer Screening With Low-Dose CT: Evidence, AI Integration, and Implementation Challenges Lancet (London, England) 2022 Landmark-class SPIRIT-Path: International Consensus Guidelines for Pathology Content in Clinical Trial Protocols The Lancet. Oncology 2021 Landmark-class Computational Pathology Risk Score Predicts Survival and Benefit from Adjuvant Chemotherapy in Early-Stage Lung Cancer EBioMedicine 2021 Landmark-class Deep Learning in Histopathology: Bridging the Gap Between Proof-of-Concept and Clinical Adoption Nature medicine 2021 Landmark-class Immunophenotype and Proliferation Scores Independently Predict Pathologic Complete Response in Triple-Negative Breast Cancer JAMA oncology 2021 Landmark-class Designing Rigorous Deep Learning Studies in Cancer Diagnostics: Protocol and Validation Standards Nature reviews. Cancer 2021 Landmark-class Deep Learning Predicts Microsatellite Instability From H&E Slides, Outperforming Expert Pathologists The Lancet. Oncology 2021 Landmark-class Digital vs. Light Microscopy Diagnostic Concordance: A Systematic Review and Meta-Analysis of 10,410 Samples Journal of clinical pathology 2020 Landmark-class 2019 ISUP Consensus Updates Prostate Cancer Grading and Embraces AI and Cribriform Reporting The American journal of surgical pathology 2020 Landmark-class BRCA1/2 Germline Variants Predict Higher pCR Rates Across Neoadjuvant Regimens in Triple-Negative and HR-Positive Breast Cancer JAMA oncology 2020 Landmark-class Deep Learning Detects Papilledema from Fundus Photographs with AUC 0.96 in Global Validation The New England journal of medicine 2020 Landmark-class Systematic Review Exposes Fundamental Design and Reporting Flaws in Deep Learning Diagnostic Studies BMJ (Clinical research ed.) 2020 Landmark-class Automated Deep Learning System for Gleason Grading Outperforms Most Pathologists The Lancet. Oncology 2020 Landmark-class GRAIDS: Real-Time AI System Matches Expert Endoscopists for Upper GI Cancer Detection The Lancet. Oncology 2019 Landmark-class Digital Pathology Association White Paper Defines Best Practices and Regulatory Recommendations for Computational Pathology The Journal of pathology 2019 Landmark-class AI-Powered Digital Pathology: New Biomarker Discovery Tools for Precision Oncology Nature reviews. Clinical oncology 2019 Landmark-class AI in Digital Pathology: A UK Roadmap From Development to Regulatory Approval and Clinical Use The Journal of pathology 2019 Landmark-class Deep Learning in Healthcare: A Technical Guide Spanning Imaging, NLP, and Genomics Nature medicine 2019 Landmark-class CT Radiomics Signature Predicts CD8 Cell Infiltration and Immunotherapy Response The Lancet. Oncology 2018 Landmark-class TCGA PanCancer Atlas: Untapped Potential of Digital Pathology Archives for Computational Analysis The Journal of pathology 2018 Landmark-class Deep Learning System Validated for Diabetic Retinopathy Screening Across Multiethnic Populations JAMA 2017 Landmark-class Atrial Fibrillation in 2026: Wearable Detection, Integrated Care, and Evolving Ablation Strategy Lancet (London, England) 2026 Significance 7/10 Minocycline Improves Functional Outcomes After Acute Ischaemic Stroke in Phase III Trial Lancet (London, England) 2026 Significance 7/10 Hierarchical Pyramid Transformer Achieves 84% Accuracy for Automated Breast Cancer Molecular Subtyping From H&E Slides The Journal of pathology 2026 Significance 7/10 Antimicrobial Resistance in 2025: Global Landscape, New Antibiotics, and the Promise of AI-Enabled Stewardship BMJ (Clinical research ed.) 2025 Significance 7/10 Precision Oncology 2025 in Review: New Targets, Liquid Biopsy, and AI-Driven Insights Cancer discovery 2025 Significance 7/10 Individualized Blood Pressure Targets During Major Surgery Do Not Improve Postoperative Outcomes JAMA 2025 Significance 7/10 Lancet Review: Non-Invasive Cardiac Imaging and AI for Chronic Coronary Artery Disease Diagnosis Lancet (London, England) 2025 Significance 7/10 Computational Pathology for Colorectal Cancer: Bridging the Gap Between AI Research and the 20-Element Clinical Report NPJ precision oncology 2025 Significance 7/10 AI in Hematology: Diagnostic Accuracy, Risk Stratification, and the Road to Clinical Implementation Blood 2025 Significance 7/10 AI-RAPNO Review: Current State and Future Directions for AI in Paediatric Neuro-Oncology Imaging The Lancet. Oncology 2025 Significance 7/10 AI-RAPNO Part 2: Recommendations for Clinical Translation of AI in Paediatric Neuro-Oncology Response Assessment The Lancet. Oncology 2025 Significance 7/10 Deep Learning Predicts Axillary Pathological Complete Response in Breast Cancer Using Longitudinal Ultrasound EBioMedicine 2025 Significance 7/10 Virtual IHC Staining From H&E in Breast Cancer: A Benchmark of Deep Generative Models for HER2, ER, PgR and Ki-67 NPJ digital medicine 2025 Significance 7/10 Lancet Series: Precision Monitoring and AI-Driven Diagnostics Are Reshaping Transplant Medicine Lancet (London, England) 2025 Significance 7/10 Acquired Therapy Resistance in Cancer: A Roadmap for AI-Driven Prediction and Prevention Nature reviews. Cancer 2025 Significance 7/10 AI in Breast Pathology: From HER2 Quantification to Novel Biomarker Discovery Human pathology 2025 Significance 7/10 Multimodal Generative AI for Automated Medical Image Reporting: Progress and Clinical Path Forward Nature 2025 Significance 7/10 GPT-4 Improves Physician Performance on Clinical Management Reasoning Tasks Nature medicine 2025 Significance 7/10 Immunotherapy Advances in Squamous Lung Cancer: Biomarker Challenges and Emerging Multi-Omics Strategies Nature reviews. Clinical oncology 2025 Significance 7/10 Digital Health Intervention Reduces Childhood Obesity in Diverse Population: Greenlight Plus RCT JAMA 2024 Significance 7/10 Patient-Derived Xenograft Models for Functional Precision Oncology in the AI Era Nature reviews. Cancer 2024 Significance 7/10 Wearable Biosensors for Body-Fluid Analysis: From Sweat to Interstitial Fluid Monitoring Nature 2024 Significance 7/10 Early Cancer Biology: Emerging Models and Multi-Omics Tools for Detecting Precancerous Transformation Nature reviews. Cancer 2024 Significance 7/10 Automated MRI System Predicts Axillary Complete Response to Neoadjuvant Chemotherapy in Breast Cancer EBioMedicine 2024 Significance 7/10 Spatial Immune Infiltrate Mapping Predicts Outcomes in High-Risk Soft Tissue Sarcomas After Neoadjuvant Chemotherapy EBioMedicine 2024 Significance 7/10 Precision Public Health: Integrating Genomics, Big Data, and AI for Population-Level Disease Prevention Nature medicine 2024 Significance 7/10 Radiopharmaceutical Sciences in Oncology: Advances in Theranostics, Radionuclide Production, and AI The Lancet. Oncology 2024 Significance 7/10 AI Matches Expert Dermatologists but Significantly Outperforms Generalists in Skin Cancer Diagnosis NPJ digital medicine 2024 Significance 7/10 AI in Digital Pathology Shows High Accuracy but Pervasive Risk of Bias Across 100 Studies NPJ digital medicine 2024 Significance 7/10 AI in Oncology: Current Clinical Integration Across Detection, Diagnosis, and Treatment Cancer discovery 2024 Significance 7/10 Neoadjuvant Nivolumab Plus Relatlimab Is Feasible and Safe Before Lung Cancer Surgery Nature medicine 2024 Significance 7/10 Understanding Clinical Impact of AI Errors in Histopathology: Beyond Technical Performance Metrics NPJ digital medicine 2024 Significance 7/10 Deep Learning in Cancer Genomics and Histopathology: Applications, Biases, and Future Workflows Genome medicine 2024 Significance 7/10 Future of Valvular Heart Disease: AI Digital Twins, Pharmacological Targets, and Bioengineered Valves Lancet (London, England) 2024 Significance 7/10 Meta-Analysis: Regional Node Radiotherapy Reduces Breast Cancer Mortality in Modern Trials Lancet (London, England) 2023 Significance 7/10 Early vs Delayed Blood Pressure Lowering Shows No Benefit in Acute Ischaemic Stroke BMJ (Clinical research ed.) 2023 Significance 7/10 AI in Diagnostic Pathology: From Whole-Slide Imaging to FDA-Approved Clinical Tools Diagnostic pathology 2023 Significance 7/10 AI in Ovarian Cancer Histopathology: Systematic Review Reveals Universal Risk of Bias NPJ precision oncology 2023 Significance 7/10 AI-Driven Tumour Microenvironment Analysis From Digital H&E Images to Predict Prognosis and Treatment Response The Journal of pathology 2023 Significance 7/10 Unlocking AI for Pathology: A Systematic Analysis of Development and Deployment Barriers The Journal of pathology 2023 Significance 7/10 Integrative Deep Learning Combining Pathology, Clinical, and Genomic Data Improves Colon Cancer Risk Stratification EBioMedicine 2023 Significance 7/10 Deep Learning Radiopathomics Distinguishes Luminal from Non-Luminal Breast Cancer Before Surgery EBioMedicine 2023 Significance 7/10 AI for Infectious Disease Surveillance: From Digital Epidemiology to Outbreak Prediction The New England journal of medicine 2023 Significance 7/10 GeparX Trial: Denosumab Adds No Benefit to Neoadjuvant Chemotherapy; Weekly nab-Paclitaxel Outperforms Biweekly Schedule JAMA oncology 2022 Significance 7/10 AI in Lung Digital Pathology: From PD-L1 Quantification to Treatment Response Prediction The Journal of pathology 2022 Significance 7/10 Integrating Computational Pathology and Proteomics to Overcome Tumor Heterogeneity The Journal of pathology 2022 Significance 7/10 AI-Derived Stroma-Infiltrating Lymphocyte Score Predicts Survival in Head and Neck Squamous Cell Carcinoma The Journal of pathology 2021 Significance 7/10 Neoadjuvant Therapy in Early-Stage NSCLC: Biomarker Discovery and the Role of Digital Pathology and Radiomics The Lancet. Oncology 2021 Significance 7/10 The Curse of Dimensionality: Why High-Dimensional Health Data Challenge AI Generalization NPJ digital medicine 2021 Significance 7/10 Multimodal Data Integration for Precision Oncology: Merging Genomics, Imaging, and Clinical Data Nature reviews. Cancer 2021 Significance 7/10 Radiomics and AI in Oncology Imaging: From Diagnosis to Outcome Prediction Nature reviews. Clinical oncology 2021 Significance 7/10 BMJ Review: Evidence for AI in Breast Cancer Screening Remains Insufficient for Clinical Deployment BMJ (Clinical research ed.) 2021 Significance 7/10 Systematic Review Finds High but Heterogeneous Diagnostic Accuracy for Deep Learning in Medical Imaging NPJ digital medicine 2021 Significance 7/10 AI in Cancer Research: From Molecular Characterisation to Treatment Prediction Cancer discovery 2021 Significance 7/10 AI in Pathology: Current Clinical Applications and the Road to Precision Medicine Journal of clinical pathology 2020 Significance 7/10 AI and Global Health: From Tuberculosis Diagnostics to Disease Surveillance in Low-Resource Settings Lancet (London, England) 2020 Significance 7/10 Neuroimaging Biomarker for Striatal Dysfunction Distinguishes Schizophrenia with 80% Accuracy Nature medicine 2020 Significance 7/10 AI in Clinical and Genomic Diagnostics: From Variant Calling to Phenotype-Genotype Mapping Genome medicine 2019 Significance 7/10 Practical Guide to ISO 15189 Accreditation for Digital Pathology in Clinical Laboratories Journal of clinical pathology 2019 Significance 7/10 Digital Pathology and AI: Advancing Computer-Aided Diagnosis Beyond the Microscope The Lancet. Oncology 2019 Significance 7/10 Full Digitisation of Clinical Immunohistochemistry: Validation Across 1,480 Slides Shows Complete Concordance Journal of clinical pathology 2019 Significance 7/10 Patient Privacy in the Era of Medical Big Data and AI: Legal and Ethical Challenges Nature medicine 2019 Significance 7/10 Deep Learning Accurately Detects Critical Head CT Findings, Enabling Automated Triage Lancet (London, England) 2018 Significance 7/10 AI in Radiology: Deep Learning Methods for Quantitative Medical Image Analysis Nature reviews. Cancer 2018 Significance 7/10 Multiplexed Fluorescence IHC Quantifies Compartment-Specific Immune Infiltrates and Predicts Lung Cancer Prognosis The Journal of pathology 2018 Significance 7/10 uPath HER2 Dual ISH Image Analysis Algorithm Validated for Automated HER2 Testing in Breast Cancer Journal of clinical pathology 2026 Significance 6/10 AI-Driven Crop Improvement: Integrating Genome Editing, Protein Design, and Multi-Omics Data Nature 2025 Significance 6/10 AI, Xenotransplantation, and Regenerative Medicine Are Converging to Address the Organ Shortage Crisis Nature medicine 2025 Significance 6/10 Large Language Models in Precision Oncology: From Screening to Treatment Recommendation EBioMedicine 2025 Significance 6/10 AI-Powered Cardiovascular Risk Assessment: A Scoping Review of Machine Learning and Deep Learning Approaches EClinicalMedicine 2024 Significance 6/10 Practical Guide to AI for Cancer Researchers: Image Analysis, NLP, and Drug Discovery Nature reviews. Cancer 2024 Significance 6/10 AI in Neuro-Oncology: Advances in Glioma Diagnosis, Molecular Profiling, and Precision Treatment NPJ precision oncology 2024 Significance 6/10 LLMs in Diagnostic Medicine: Scoping Review Maps Key Barriers for Digital Pathology Integration Diagnostic pathology 2024 Significance 6/10 AI in Breast Cancer Pathology: Comprehensive Review of Diagnostic, Grading, and Predictive Applications Diagnostic pathology 2024 Significance 6/10 AI Chatbots in Clinical Laboratory Medicine: Capabilities, Limitations, and Path Forward Clinical chemistry 2023 Significance 6/10 Machine Learning Image Analysis Is Beginning to Transform Clinical Microbiology Practice Journal of clinical microbiology 2023 Significance 6/10 Ex Vivo Confocal Laser Microscopy Enables Real-Time Digital Assessment of Pancreatic EUS-FNB Specimens EBioMedicine 2022 Significance 6/10 Deep Learning on CT Scans Predicts Major Pathological Response to Neoadjuvant Chemoimmunotherapy in NSCLC EBioMedicine 2022 Significance 6/10 AI in Lung Cancer: Diagnostic Imaging, Treatment Selection, and Prognostic Assessment Clinical chemistry and laboratory medicine 2022 Significance 6/10 High-Throughput Whole-Slide Scanning: Strategies for Building Large-Scale Digital Pathology Repositories The Journal of pathology 2022 Significance 6/10 Clinical Decision Support in Cardiovascular Medicine: Promise, Barriers, and Regulatory Landscape BMJ (Clinical research ed.) 2022 Significance 6/10 Developing Practical Image Analysis Methods for Digital Pathology: From Algorithm to Usable Software The Journal of pathology 2022 Significance 6/10 Machine Learning in Routine Laboratory Medicine: Automation, Utilisation, and Personalised Reference Ranges Clinical biochemistry 2022 Significance 6/10 AI Models for Gastric Cancer Diagnosis and Prognosis from Digital Pathology Images EBioMedicine 2021 Significance 6/10 Mitotic Activity Assessment in Breast Cancer Revisited for the Digital Pathology Era Journal of clinical pathology 2021 Significance 6/10 Colorectal Cancer Screening: Current Modalities, AI-Assisted Detection, and Persistent Gaps in Uptake BMJ (Clinical research ed.) 2021 Significance 6/10 Digital Pathology Grading of Renal Cell Carcinoma Is Non-Inferior to Glass Slides, With Potential for Improved Interobserver Agreement Diagnostic pathology 2021 Significance 6/10 AI-Powered Biomarker Evaluation for Personalised Treatment in Breast and Prostate Cancer Journal of clinical pathology 2021 Significance 6/10 Deep Learning for Medical Computer Vision: A Decade of Progress Across Clinical Domains NPJ digital medicine 2021 Significance 6/10 From Scanner Park to AI Integration: A 15-Year Journey to Full Digital Diagnostic Pathology Journal of clinical pathology 2020 Significance 6/10 Digital Pathology and AI as Critical Infrastructure for Pathology Services During COVID-19 and Future Crises Journal of clinical pathology 2020 Significance 6/10 Software-Assisted Decision Support in Digital Histopathology: From Biomarker Scoring to Multiplexed Analysis The Journal of pathology 2020 Significance 6/10 Training and Validation Protocol for Primary Diagnosis With Digital Pathology: The Leeds Experience Journal of clinical pathology 2019 Significance 6/10 Whole-Slide Imaging Outperforms Robotic Microscopy for Intraoperative Frozen Section Teleconsultation Journal of clinical pathology 2019 Significance 6/10 Mitotic Figure Detection Across Microscopy and Multiple Whole-Slide Scanners: A Multi-Observer Validation Study Diagnostic pathology 2019 Significance 6/10 Multicentre Audit Reveals High Interobserver Variability in Breast Fibroepithelial Lesion Diagnosis on Digital Pathology Journal of clinical pathology 2018 Significance 6/10 Future-Proofing Pathology: Strategic Case for Clinical Adoption of Digital Pathology Journal of clinical pathology 2017 Significance 6/10 Free Web-Based ImmunoRatio Tool Reliably Automates Ki-67 Scoring in Breast Cancer Journal of clinical pathology 2017 Significance 6/10 Polish Society of Pathologists Issues National Guidelines for Digital Pathology Adoption Diagnostic pathology 2026 Significance 5/10 Embodied AI in Ophthalmology: From Perception to Autonomous Clinical Action NPJ digital medicine 2025 Significance 5/10 Digital Pathology in 2025: An Update on Clinical Diagnosis, Telepathology, Education and Research Applications Diagnostic pathology 2025 Significance 5/10 Radiotherapy Innovation for Low-Income Settings: AI, Deep Phenotyping, and Real-Time Targeting The Lancet. Oncology 2024 Significance 5/10 Practical Guide to Using Digital Slides in Histopathology Education Journal of clinical pathology 2024 Significance 5/10 Adopting AI-Enabled Digital Pathology in Resource-Limited Settings: A Practical Framework for Developing Countries Diagnostic pathology 2023 Significance 5/10 Histologic Evaluation of Celiac Disease: Current Best Practice and the Promise of Digital Quantitative Pathology Human pathology 2022 Significance 5/10 Stanford-Lancet Commission Issues Comprehensive Recommendations to Combat the Opioid Crisis Lancet (London, England) 2022 Significance 5/10 Digital Pathology During COVID-19: How Whole Slide Imaging Sustained Diagnostic Workflows Journal of clinical pathology 2020 Significance 5/10 The Digital Scribe: AI-Powered Clinical Documentation from Dictation to Intelligent Environments NPJ digital medicine 2018 Significance 5/10 Computer-Aided Diagnosis System Using Triple IHC Markers Classifies Breast Epithelial Proliferative Lesions Journal of clinical pathology 2017 Significance 5/10 Digital Whole-Slide Imaging Validated for Preimplantation Kidney Biopsy Assessment Human pathology 2015 Significance 5/10 Edaravone Dexborneol Improves Functional Independence After Thrombectomy in Acute Ischemic Stroke BMJ (Clinical research ed.) 2026 Significance 4/10 Sustainable Surgical Pathology: Carbon Footprint Reduction Through Digital Pathology and Green AI Journal of clinical pathology 2025 Significance 4/10 Pathology Archive Management: Cost Analysis and the Case for Digital Tracking Systems Journal of clinical pathology 2023 Significance 4/10 Whole Slide Imaging for Distance Teaching: Lessons from a Caribbean-Canadian Pathology Education Partnership Journal of clinical pathology 2020 Significance 4/10 Annual Review of Advances in Pathology: Digital Tools, Biomarkers, Genetics and the Tumour Stroma The Journal of pathology 2020 Significance 4/10 AI Powers Digital Medicine: From Diagnosis to Treatment Decision Support NPJ digital medicine 2018 Significance 4/10 Chairing an Academic Pathology Department: Navigating Clinical Service, Research and Administrative Challenges Journal of clinical pathology 2018 Significance 3/10