Troponin T and the Redefinition of the Myocardial Infarction Gold Standard

This historical review by E. Magnus Ohman traces how cardiac troponin T transformed the diagnostic gold standard for myocardial infarction, replacing CK-MB and reshaping clinical trial endpoints and treatment thresholds. The narrative illustrates how a single laboratory biomarker fundamentally altered the definition, epidemiology, and management of the most common cause of cardiovascular death.