NEJM Review: Neuroleptic Malignant Syndrome Diagnosis and Management

This NEJM review covers the clinical presentation, pathophysiology, and management of neuroleptic malignant syndrome, a rare but life-threatening adverse reaction to dopamine-blocking agents. While primarily a clinical topic, the review is relevant to laboratory professionals who may encounter the characteristic pattern of elevated creatine kinase, leukocytosis, and metabolic derangements that support the diagnosis. Rapid laboratory recognition of this biomarker constellation can accelerate clinical intervention in emergency settings.