How-To Guide for Building Pharmacogenomic Clinical Decision Support Systems
This practical review provides a step-by-step framework for implementing pharmacogenomic clinical decision support, structured around the five CDS 'rights': right information, right person, right format, right channel, and right time. It surveys CDS tool types from passive to interruptive alerts and discusses optimisation strategies. For laboratory informatics teams integrating PGx results into EHR workflows, the paper offers an actionable implementation blueprint.
The original study
Pharmacogenomic Clinical Decision Support: A Review, How-to Guide, and Future Vision.
- Authors
- Wake DT, Smith DM, Kazi S, Dunnenberger HM
- Journal
- Clinical pharmacology and therapeutics
- Type
- Journal Article, Review
- PMID
- 34365648
Original abstract
Clinical decision support (CDS) is an essential part of any pharmacogenomics (PGx) implementation. Increasingly, institutions have implemented CDS tools in the clinical setting to bring PGx data into patient care, and several have published their experiences with these implementations. However, barriers remain that limit the ability of some programs to create CDS tools to fit their PGx needs. Therefore, the purpose of this review is to summarize the types, functions, and limitations of PGx CDS currently in practice. Then, we provide an approachable step-by-step how-to guide with a case example to help implementers bring PGx to the front lines of care regardless of their setting. Particular focus is paid to the five "rights" of CDS as a core around designing PGx CDS tools. Finally, we conclude with a discussion of opportunities and areas of growth for PGx CDS.