Archive

Midplex GI PCR panel preserves diagnostic yield while reducing colonization detection The journal of applied laboratory medicine 2026 Significance 6/10 Saliva liquid biopsy captures multi-omic disease signals across oral and systemic conditions Journal of periodontal research 2026 Significance 4/10 Whole-genome sequencing tracks ST80 dissemination and combined vancomycin-linezolid resistance in VREfm Microbiology spectrum 2026 Significance 4/10 Whole exome sequencing reveals monogenic mimics in pediatric Cogan syndrome Rheumatology (Oxford, England) 2026 Significance 5/10 Respiratory virus testing shows limited impact on antibiotic prescribing in primary care Journal of primary health care 2026 Significance 3/10 Triplex RPA assay enables rapid, sensitive detection of three bovine pathogens Sheng wu gong cheng xue bao = Chinese journal of biotechnology 2026 Significance 4/10 Paper-based POC platform enables rapid whole-blood PT/INR and haematocrit monitoring with AI classification Lab on a chip 2026 Significance 7/10 Dried blood spot screening for congenital hypothyroidism supports newborn screening expansion in Pakistan Endocrinology, diabetes & metabolism 2026 Significance 7/10 AI and digital TIL scoring stratify pertuzumab benefit in HER2-positive breast cancer The Lancet. Oncology 2026 Significance 7/10 Single-cell CTC profiling captures PI3K/AKT/PTEN alterations missed by ctDNA in metastatic breast cancer Cancer science 2026 Significance 5/10 Adapting trauma guidelines and point-of-care diagnostics improves LMIC polytrauma outcomes World journal of methodology 2026 Significance 6/10 Exosome-derived proteins and RNAs emerge as non-invasive biomarkers for stroke and neurodegeneration Metabolic brain disease 2026 Significance 3/10 Pan-filovirus immunoassay delivers reproducible serosurveillance results across US and DRC laboratories PloS one 2026 Significance 7/10 Molecular subclassification and CSF liquid biopsy guide risk-adapted therapy in infant CNS embryonal tumors Pediatric blood & cancer 2026 Significance 5/10 Multicenter Indian registry maps genetic variants and clinical phenotypes in pediatric distal renal tubular acidosis Pediatric nephrology (Berlin, Germany) 2026 Significance 6/10 Interval-specific likelihood ratios refine antiphospholipid antibody interpretation across automated platforms Clinical chemistry and laboratory medicine 2026 Significance 6/10 Multiplex PCR enables rapid, highly accurate diagnosis of tuberculous meningitis Journal of clinical microbiology 2026 Significance 7/10 Integrated rapid diagnostics and AI prediction accelerate targeted antibiotic therapy in a resource-limited setting PloS one 2026 Significance 7/10 AI-assisted Pap screening improves specificity for atypical glandular cells and cervical neoplasia Cancer cytopathology 2026 Significance 6/10 Decentralized POC HCV testing achieves over 90% uptake in LMICs Liver international : official journal of the International Association for the Study of the Liver 2026 Significance 7/10 AI and chemical engineering accelerate aptamer development for diagnostics and therapeutics FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Significance 3/10 Prenatal exome sequencing could have diagnosed one-fifth of monogenic cases missed by ultrasound Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 2026 Significance 6/10 Mechanically automated paper-based CRISPR/RPA platform enables instrument-free Vibrio vulnificus detection ACS sensors 2026 Significance 6/10 CRISPR-Cas12a hydrogel microarray enables multiplex adenovirus detection with qPCR concordance ACS infectious diseases 2026 Significance 5/10 CRISPR RNA engineering strategies enhance single-nucleotide discrimination in nucleic acid diagnostics Angewandte Chemie (International ed. in English) 2026 Significance 5/10 Amniotic fluid proteomic panel stratifies persistent versus transient fetal growth restriction Annals of medicine 2026 Significance 6/10 BV Rapid Blue demonstrates high sensitivity and NPV for bacterial vaginosis screening in pregnancy PloS one 2026 Significance 6/10 Point-of-care multiplex PCR reduces isolation costs for non-infected HCID suspects in economic model Infection 2026 Significance 5/10 Pleural fluid IL-9 accurately distinguishes tuberculous from adenocarcinoma-associated malignant effusions Lung 2026 Significance 5/10 UNI2-h foundation model leads cross-domain histology classification, lightweight models optimize speed Microscopy research and technique 2026 Significance 4/10 One-pot CRISPR/Cas12a system enables direct RNA and DNA detection without thermal cycling ACS sensors 2026 Significance 6/10 Carbapenemase-producing Enterobacteriaceae detected in nearly one-fifth of clinical isolates in Addis Ababa PloS one 2026 Significance 5/10 Codon optimization depletes stop codons that limit out-of-frame translation in mRNA therapeutics Proceedings of the National Academy of Sciences of the United States of America 2026 Landmark-class Pharmacoexposomics framework integrates environmental metabolomics with pharmacogenomics via high-resolution mass spectrometry Annual review of pharmacology and toxicology 2026 Significance 3/10 AI assistance increases cancer detection in routine mammography without prolonging reading time European radiology 2026 Significance 6/10 ASC committee review maps LLM applications, validation requirements and regulatory pathways for cytopathology Cancer cytopathology 2026 Significance 6/10 Colourimetric LAMP assay achieves 100% sensitivity and specificity for field detection of poultry erysipelas Veterinary medicine and science 2026 Significance 4/10 Point-of-care sickle cell screening enables universal testing and cuts national costs in India PloS one 2026 Significance 7/10 FOLR1 expression is rare in endometrial carcinoma and concentrated in p53-abnormal subtypes International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2026 Significance 5/10 NIPT interpretation requires tailored algorithms for donor-oocyte pregnancies Molecular diagnosis & therapy 2026 Significance 5/10 Metabolomic profiling identifies candidate biomarkers for primary heart graft dysfunction The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2026 Significance 5/10 Quantitative proteomics maps species-specific fish allergenomes for improved allergy diagnostics International journal of biological macromolecules 2026 Significance 6/10 NAAT plus wet mount is cost-effective for symptomatic trichomoniasis screening in US primary care Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2026 Significance 5/10 Nanomaterials and SERS target sensitivity and quantification gaps in lateral flow immunoassays Clinica chimica acta; international journal of clinical chemistry 2026 Significance 5/10 ctDNA, microbiome and inflammatory scores converge on noninvasive colorectal cancer staging Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2026 Significance 5/10 Routine liquid-based cytology specimens support lung cancer NGS panel testing Cancer cytopathology 2026 Significance 5/10 Routine ECG screening reveals 7.9% atrial fibrillation prevalence in Ugandan adults with type 2 diabetes Cardiovascular diabetology. Endocrinology reports 2026 Significance 5/10 Dual-mismatch crRNA enables high-fidelity CRISPR SNV detection and equipment-free POCT ACS sensors 2026 Significance 7/10 Pediatric hematuria screening with targeted NGS enables family cascade testing for COL4A nephropathies Journal of nephrology 2026 Significance 4/10 Automated integrated DNA-RNA NGS achieves 98.7% success and eight-day turnaround in routine solid tumor profiling Virchows Archiv : an international journal of pathology 2026 Significance 5/10 16S/18S NGS metabarcoding supplements culture rather than replacing it in infectious keratitis Acta ophthalmologica 2026 Significance 5/10 Portable RT-LAMP workflow detects HIV-1 and HCV directly from blood in 32 minutes Microbiology spectrum 2026 Significance 5/10 Baseline PET/CT heterogeneity index shows limited independent value for predicting lung cancer treatment response Hellenic journal of nuclear medicine 2026 Significance 4/10 Validated LC-MS/MS reference method enables global standardization of meropenem therapeutic drug monitoring Clinical chemistry and laboratory medicine 2026 Significance 7/10 Multianalyte liquid biopsy shows promise for monitoring head and neck squamous cell carcinoma DNA and cell biology 2026 Significance 5/10 Consensus costing and volume forecasting guide bacteriology laboratory implementation in sub-Saharan Africa The Lancet. Microbe 2027 Significance 7/10 Early serum free light chain normalization provides complementary prognostic data in multiple myeloma Hematological oncology 2026 Significance 5/10 NGS profiling refines prognosis and identifies targetable mutations in Mexican pediatric preB-ALL The journal of pathology. Clinical research 2026 Significance 6/10 LAP-MALI mass spectrometry enables rapid multiplex AMR profiling and bacterial identification Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Significance 6/10 Dual-probe RT-LAMP assay enables rapid subtype-specific detection of RSV A and B PloS one 2026 Significance 6/10 Near-POC swab TB assays expand access despite sensitivity tradeoffs for trace signals The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2026 Significance 6/10 High admission bicarbonate predicts early diuretic resistance in acute heart failure Cardiovascular journal of Africa 2026 Significance 5/10 Validated LC-MS/MS assay enables therapeutic drug monitoring of MDR-TB drugs in HIV-coinfected patients Journal of mass spectrometry : JMS 2026 Significance 6/10 Circulating mtDNA meta-analysis confirms diagnostic accuracy and prognostic value but highlights need for assay standardization Cancer medicine 2026 Significance 7/10 Metabolomic profiling identifies serum markers predicting cabozantinib resistance in advanced renal cell carcinoma Cancer medicine 2026 Significance 4/10 Week-12 MRD negativity and HSCT improve survival in pediatric KMT2A-rearranged lymphoid neoplasms Zhonghua er ke za zhi = Chinese journal of pediatrics 2026 Significance 4/10 MEF2D-rearranged pediatric B-ALL shows high relapse risk despite negative post-induction MRD Zhonghua er ke za zhi = Chinese journal of pediatrics 2026 Significance 3/10 High C16orf74 expression correlates with poor survival in extrahepatic cholangiocarcinoma Anticancer research 2026 Significance 4/10 Urinary 11-metabolite panel distinguishes ADHD from controls in children Metabolomics : Official journal of the Metabolomic Society 2026 Significance 5/10 Salivary proteomics reveals distinct protein signatures in hookah versus cigarette smokers Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2026 Significance 3/10 IVDR implementation curbs innovation and shifts new product launches away from the EU Expert review of medical devices 2026 Significance 6/10 Tiered molecular testing framework aims to bridge global glioma diagnostics disparities Annals of clinical and translational neurology 2026 Significance 7/10 Combined qPCR and NGS workflow improves pathogen detection in culture-negative periprosthetic joint infections Microbiology spectrum 2026 Significance 5/10 Validated PoC immunoturbidimetric device enables rapid urinary albumin testing for early CKD screening Journal of clinical laboratory analysis 2026 Significance 6/10 Dry chemistry and microfluidics streamline point-of-care diagnostics for resource-limited settings Bioanalysis 2026 Significance 5/10 Meta-analysis identifies eight-gene transcriptomic panel with high diagnostic accuracy for breast cancer Cancer medicine 2026 Significance 4/10 LPF detection speed predicts cytology accuracy better than years of experience Cancer cytopathology 2026 Significance 5/10 MALDI-TOF mass spectrometry outperforms urine immunofixation for detecting Bence Jones proteins in myeloma and amyloidosis Clinical chemistry and laboratory medicine 2026 Significance 6/10 Genomic profiling and ctDNA integration guide adaptive therapy across NSCLC stages Cancer journal (Sudbury, Mass.) 2026 Significance 5/10 Melanocytic transcriptomic state predicts poor survival in metastatic melanoma Science advances 2026 Significance 5/10 MRI-based dural sac index improves detection of tethered cord syndrome Journal of neurosurgery. Spine 2026 Significance 5/10 Optimized LC-HRMS workflow improves urinary metabolomics reproducibility for bladder cancer profiling Analytical and bioanalytical chemistry 2026 Significance 4/10 CKD-EPI 2009 outperforms MDRD-IDMS for eGFR estimation in heterogeneous hospital cohorts International urology and nephrology 2026 Significance 4/10 Circular RNAs show promise as stable liquid biopsy biomarkers for minimal residual disease Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2026 Significance 4/10 NGS hotspot panel characterizes TP53 and PIK3CA mutation frequencies in Ukrainian breast cancer Cancer control : journal of the Moffitt Cancer Center 2026 Significance 4/10 BAP1 and CDKN2A alterations predict shorter PFS to pemigatinib in FGFR2-positive cholangiocarcinoma Liver international : official journal of the International Association for the Study of the Liver 2026 Significance 6/10 Extraction-free duplex HiFi-LAMP enables rapid point-of-care screening for chlamydia and gonorrhoea Microbiology spectrum 2026 Significance 6/10 Integrated biomarker testing expands lung cancer diagnostics with tissue NGS, ctDNA, and AI Cancer journal (Sudbury, Mass.) 2026 Significance 5/10 CRISPR-Cas12a assay detects Shigella flexneri 2a in clinical stool samples with PCR-level accuracy Journal of clinical microbiology 2026 Landmark-class mNGS of BAL fluid improves pathogen detection and guides therapy in pediatric PICU pneumonia Microbiology spectrum 2026 Significance 5/10 VirMask computational tool reduces false positives in clinical viral metagenomic sequencing Journal of clinical microbiology 2026 Significance 7/10 CDC and APHL publish phase 2 guidance on implementing NGS quality management systems Journal of clinical microbiology 2026 Significance 6/10 Routine reanalysis of unsolved NGS data achieves 16.8 percent diagnostic yield in neuromuscular disorders Journal of neurology 2026 Significance 5/10 Concurrent tissue and liquid NGS improves NSCLC mutation detection, with blood capturing tissue-negative cases American journal of respiratory and critical care medicine 2026 Significance 6/10 Tetraplex Cobas Liat platform achieves 100% sensitivity for SARS-CoV-2, influenza, and RSV in clinical evaluation Journal of clinical microbiology 2026 Significance 6/10 ID-LC-MS/MS candidate reference procedure standardizes serum DHEAS quantification Journal of mass spectrometry : JMS 2026 Significance 6/10 LC-MS/MS assay accurately discriminates CYP2D6 poor metabolizers using diet-derived solanidine biomarkers Clinical and translational science 2026 Significance 5/10 Smartphone-powered electrochemical lateral flow assay delivers ELISA-level plant disease detection in East Africa Proceedings of the National Academy of Sciences of the United States of America 2026 Landmark-class Lactate-to-albumin ratio outperforms lactate for sepsis mortality prediction in large ICU cohort JMIR medical informatics 2026 Significance 5/10 Higher pregnancy vitamin D dosing achieves biochemical sufficiency without improving neonatal bone mineral content The Journal of clinical endocrinology and metabolism 2026 Significance 6/10 LDI-MS with Co3O4@Au nanohybrid matrix enables machine learning diagnosis of esophageal cancer Analytical chemistry 2026 Significance 5/10 Chemically synthesized protein-encoding RNA oligonucleotides enable IVT-free rapid vaccine manufacturing Proceedings of the National Academy of Sciences of the United States of America 2026 Significance 5/10 CRISPR-enhanced LSPR biosensor enables simultaneous ultrasensitive detection of telomerase and fibrin The Analyst 2026 Significance 5/10 CRISPR/Cas12a logic gate enables simultaneous KRAS mutation and Septin9 methylation detection Analytical methods : advancing methods and applications 2026 Significance 5/10 CRISPR biosensors integrate nanomaterials and microfluidics for preamplification-free molecular monitoring ACS sensors 2026 Significance 5/10 Optimized LC-MS/MS workflow enables high-throughput phosphatidylethanol quantification in whole blood Journal of mass spectrometry : JMS 2026 Significance 6/10 Integrated RPA-CRISPR microfluidic chip enables multiplex POCT for three major porcine viruses Analytical chemistry 2026 Significance 6/10 Rapid automated ADAMTS13 assays streamline TTP diagnosis and monitoring Expert review of hematology 2026 Significance 5/10 Downregulated lncRNA MEG3 and Beclin-1 show diagnostic potential in serous ovarian carcinoma Journal of molecular histology 2026 Significance 3/10 NIR-II fluorescence tomography enables 3D intraoperative mapping of human hepatocellular carcinoma IEEE transactions on bio-medical engineering 2026 Significance 4/10 CDC and PCOS Challenge outline work plan for standardized female and pediatric testosterone reference intervals The Journal of clinical endocrinology and metabolism 2026 Significance 7/10 Genomic and metabolomic profiling reveals no single pathogenic lineage in Bacteroides fragilis infections Microbiology spectrum 2026 Significance 5/10 AI accelerates genomic variant interpretation and rare disease screening despite integration and equity challenges Indian journal of pediatrics 2026 Significance 4/10 Worse visual acuity and early onset predict higher diagnostic yield in inherited retinal disease panel testing Ophthalmic epidemiology 2026 Significance 5/10 Plasma mNGS matches clinical criteria for invasive fungal infection in high-risk pediatric and young adult patients Microbiology spectrum 2026 Significance 5/10 Multiplex flow cytometry assay accurately profiles autoimmune nodopathy antibodies Journal of the peripheral nervous system : JPNS 2026 Significance 5/10 Targeted NGS achieves 28% diagnostic yield in pediatric short stature Journal of pediatric endocrinology & metabolism : JPEM 2026 Significance 4/10 Sysmex PA-100 detects bacteriuria and guides AST in companion animals but yields false positives and technical failures Microbiology spectrum 2026 Significance 3/10 Multiplex PCR reveals age-specific respiratory pathogen profiles in a single-center cohort Medicine 2026 Significance 4/10 Capillary blood HbA1c testing enables rapid field screening but shows wide accuracy variability BMC endocrine disorders 2026 Significance 6/10 Plasma pTau217 and pTau231 predict dementia progression in Parkinson’s disease NPJ Parkinson's disease 2026 Significance 6/10 MRD negativity by ctDNA and PBMCs predicts prolonged survival in relapsed follicular lymphoma Blood advances 2026 Significance 6/10 Multiplex plasma proteomics panel achieves high diagnostic accuracy for neurodegenerative dementias Alzheimer's research & therapy 2026 Significance 6/10 CRISPR biosensing workflow benchmarking highlights spiked-matrix reliance and reporting gaps Environmental science & technology 2026 Significance 4/10 Fusion LAMP combined with CRISPR/Cas13a enables dual-target MRSA detection ACS synthetic biology 2026 Significance 5/10 Automated sample preparation matches manual methods for serum trace element testing by ICP-MS/MS Clinical chemistry and laboratory medicine 2026 Significance 7/10 ctDNA monitoring shows promise but faces genomic hurdles in sarcoma subtypes Journal of surgical oncology 2026 Significance 4/10 mNGS detects Sindbis virus in cerebrospinal fluid, revealing neuroinvasive potential in human infections Emerging microbes & infections 2026 Significance 6/10 Lipid droplet proteomics identifies GNA14 and a prognostic model for clear cell renal cell carcinoma Cancer gene therapy 2026 Significance 4/10 AI in digital pathology advances toward clinical deployment but requires rigorous validation and governance Journal of clinical pathology 2026 Significance 6/10 AI quantification of tumor-infiltrating lymphocytes improves prognostic stratification in ovarian cancer Cancer science 2026 Significance 6/10 PET-derived spatial heterogeneity metrics predict worse overall survival in cancer European journal of nuclear medicine and molecular imaging 2026 Significance 6/10 ML-refined metagenomic signatures achieve 88% accuracy for colorectal cancer diagnosis Journal of applied genetics 2026 Significance 3/10 Machine learning and multi-cohort transcriptomics pinpoint EPSTI1 for Sjögren's disease diagnosis Clinical rheumatology 2026 Significance 5/10 Trap-enhanced SERS nanoarray enables rapid urinary copper detection for Wilson disease screening The Analyst 2026 Significance 4/10 Plasma glycerophospholipid signature achieves 0.96 AUC for acute GVHD diagnosis and prognosis Biomedical chromatography : BMC 2026 Significance 4/10 Molecular profiling of organic acidemias in India achieves 95 percent diagnostic yield and maps population-specific variants Indian journal of pediatrics 2026 Significance 6/10 Point-of-care G6PD screening remains accurate in neonates using capillary blood up to one week of life PloS one 2026 Significance 6/10 Ovarian cancer diagnostics shift toward longitudinal liquid biopsy and AI integration Expert review of molecular diagnostics 2026 Significance 6/10 NGS panels for severe obesity in youths reveal high VOUS rates and limited clinical stratification utility Journal of endocrinological investigation 2026 Significance 4/10 Targeted NGS confirms DLCN score cutoff for prioritising monogenic FH testing in CAD patients PloS one 2026 Significance 5/10 ctDNA monitoring in early breast cancer requires assay standardization and pre-analytical optimization Cancer 2026 Significance 5/10 AI framework integrates imaging, pathology and multi-omics for breast cancer precision medicine Discover oncology 2026 Significance 4/10 Biomarker and disease-oriented framework proposed for neurological point-of-care testing ACS sensors 2026 Significance 5/10 Novel HLA-A*32:202 Allele Identified by NGS and Nanopore Sequencing HLA 2026 Significance 2/10 AI-Powered Urine Test Reduces Unnecessary Prostate Biopsies by Up to 23% Journal of extracellular vesicles 2026 Significance 7/10 Nine RNA-binding proteins form prognostic model for breast cancer survival International journal of immunopathology and pharmacology 2026 Significance 5/10 Keratin 7 staining reveals disease progression markers in fatty liver disease biopsies Journal of clinical pathology 2026 Significance 6/10 AI foundation models extract quantitative MRI biomarkers for knee osteoarthritis triage NPJ digital medicine 2026 Significance 7/10 Donor age and sex shape MSC secretome signalling · a framework for potency testing Stem cell research & therapy 2026 Significance 5/10 Proenkephalin predicts worsening renal function in sepsis patients Critical care (London, England) 2026 Significance 7/10 Occupational Alcohol Exposure Causes False-Positive EtG Immunoassay Results via Cross-Reacting Glucuronide Homologues Drug testing and analysis 2026 Significance 7/10 Genomic Analysis Maps Species-Specific Polymyxin Heteroresistance in E. coli and K. pneumoniae Annals of clinical microbiology and antimicrobials 2026 Significance 6/10 Liquid Biopsy Workflow Enables Single-Cell Telomere Profiling of Myeloma CTCs from Blood BioTechniques 2026 Significance 7/10 CRISPR/Cas12a Biosensor Detects Cardiac miRNA-133a at Femtomolar Sensitivity Analytical chemistry 2026 Significance 5/10 Rb Immunohistochemistry Detects CDK4/6 Inhibitor Resistance Missed by NGS in Metastatic Breast Cancer Breast cancer research and treatment 2026 Significance 7/10 Explainable AI in Oncology: Methods to Open the Black Box Technology in cancer research & treatment 2026 Significance 5/10 Phage-Derived Binding Protein Enables Rapid, Culture-Free Detection of A. baumannii Analytical chemistry 2026 Significance 6/10 European Physicians Prioritise Rapid Fever Tests for Immunocompromised Patients and Unclear Presentations BMJ open 2026 Significance 5/10 Same-Day Hepatitis C Test-and-Treat Model Trialled Using Antibody-Only Screening in Three Countries BMJ open 2026 Significance 6/10 Pleural Fluid Biomarkers Show Promise for Diagnosing Malignant Effusions and Guiding Lung Cancer Therapy Current opinion in pulmonary medicine 2026 Significance 6/10 Ceftobiprole susceptibility testing: MIC strips reliable, disk diffusion depends on breakpoints Journal of clinical microbiology 2026 Significance 7/10 Plasma Metabolomics Classifier Detects Glioma via Seven-Metabolite Liquid Biopsy Panel Research (Washington, D.C.) 2026 Significance 7/10 CRISPR-Magnetic Microbots Enable Liquid Biopsy Cancer Subtyping via Extracellular Vesicles Analytical chemistry 2026 Significance 6/10 Manganese-Powered Cas12a Enables Amplification-Free RNA Detection at Femtomolar Sensitivity Analytical chemistry 2026 Landmark-class CRISPR/Cas13a Assay Detects Salmonella in Under 60 Minutes Across Large Clinical Cohorts PLoS neglected tropical diseases 2026 Significance 7/10 One-Pot CRISPR/Cas12a Assay With Ultrashort HDA Detects Respiratory Pathogens at Attomolar Levels Analytical chemistry 2026 Significance 7/10 Genetic Testing Reshapes the Diagnostic Workup for Childhood Nystagmus International ophthalmology clinics 2026 Significance 3/10 50-Gene NGS Panel Achieves 15% Diagnostic Yield for Hereditary Breast and Ovarian Cancer Familial cancer 2026 Significance 6/10 Melanomas in Blue Nevi Lack TERT Promoter Mutations and Carry Uniformly Low Tumour Mutational Burden Virchows Archiv : an international journal of pathology 2026 Significance 6/10 Landscape Analysis of 14 Digital Pathology Platforms Offers Selection Guide for Labs Virchows Archiv : an international journal of pathology 2026 Significance 7/10 Deep Learning System Diagnoses and Predicts Recurrence of Jaw Tumours Scientific reports 2026 Significance 4/10 Ultra-Sensitive ctDNA Assay Predicts Treatment Response 65 Days Before Imaging in Esophagogastric Cancer Scientific reports 2026 Significance 7/10 Mitochondrial Lipidomics Reveals Arachidonic Acid Deficiency as Targetable Feature in Schizophrenia Journal of advanced research 2026 Significance 4/10 Pan-Cancer Lymph Node AI Achieves 100% Sensitivity With Built-In Uncertainty Safety Net NPJ digital medicine 2026 Landmark-class Six-Gene ddPCR Panel Achieves 100% Sensitivity for Thyroid Cancer Detection in FNA Specimens Thyroid research 2026 Landmark-class Global Interlaboratory Study Exposes Significant Variability in Myositis Autoantibody Testing Journal of autoimmunity 2026 Landmark-class Nanopore Full rRNA Operon Sequencing Improves Fungal Identification in Ocular Infections PeerJ 2026 Significance 6/10 Lancet Microbe Review Maps the Expanding Toolkit for Isoniazid-Resistant TB Diagnostics The Lancet. Microbe 2026 Significance 7/10 AI-Based Pathologic Response Assessment in Lung Cancer After Neoadjuvant Therapy BMC cancer 2026 Significance 5/10 Discarded Malaria Rapid Tests Repurposed for Arbovirus Surveillance in Haiti PLoS neglected tropical diseases 2026 Significance 6/10 ctDNA Misses Lung and Surgical Bed Recurrences After Pancreatic Cancer Resection Abdominal radiology (New York) 2026 Landmark-class Irregular borders in fibroadenomas are common and should not be confused with phyllodes tumours Journal of clinical pathology 2026 Significance 6/10 Comprehensive review of metrological traceability tools for urine albumin standardisation Clinical chemistry 2026 Significance 7/10 CRISPR-based lipid lowering redefines laboratory medicine's role in gene editing era Clinical chemistry 2026 Significance 7/10 NxTAG Respiratory Pathogen Panel v2 Demonstrates High Accuracy Across Five US Clinical Sites Journal of clinical microbiology 2026 Significance 7/10 LIP-MS Molecular Fishing Identifies Therapeutic Targets for a Traditional Chinese Medicine in Rheumatoid Arthritis Journal of pharmaceutical and biomedical analysis 2026 Significance 3/10 Intraoperative MRI Volumetrics Predict Survival in Lower-Grade Glioma, Especially IDH-Mutant Tumours Journal of neuro-oncology 2026 Significance 5/10 Collaborative Framework Proposed to Streamline LDT Validation Across US Hospital Labs Journal of clinical microbiology 2026 Significance 7/10 CRISPR-Based Point-of-Care Tests Push Toward Practical H. pylori Screening ACS sensors 2026 Significance 5/10 Rapid Diagnostics and Opportunistic Infections Drive Mortality in Advanced HIV Cohort in Brazil Revista panamericana de salud publica = Pan American journal of public health 2026 Significance 6/10 AI Model Predicts Druggable Mutation Probability Before Genomic Profiling in Lung Cancer JCO clinical cancer informatics 2026 Significance 7/10 AI and Molecular Biomarkers Converge to Reshape Lung Cancer Diagnostics Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2026 Significance 5/10 Tumour-Informed Copy Number Analysis Detects ctDNA Down to 0.2% Tumour Fraction EMBO molecular medicine 2026 Significance 7/10 ctDNA Emerges as Powerful Non-Invasive Biomarker Across All Stages of Bladder Cancer European urology oncology 2026 Significance 7/10 Updated CLSI guidance brings carbapenemase testing back to the clinical lab Journal of clinical microbiology 2026 Landmark-class Genomic epidemiology reveals complex VRE dynamics behind Germany's vanB surge and decline Journal of clinical microbiology 2026 Significance 6/10 Non-fumigatus Aspergillus species cause treatable lung disease but current diagnostics miss most cases Journal of clinical microbiology 2026 Significance 7/10 In memoriam: Davise Honig Larone, pioneering clinical mycologist Journal of clinical microbiology 2026 Significance 1/10 MALDI-TOF MS and PCR Panel Enable Rapid NTM Identification Directly from Blood Culture Broth Journal of microbiological methods 2026 Significance 7/10 Real-World Adjuvant Therapy Patterns After Chemoimmunotherapy in Early Triple-Negative Breast Cancer Breast cancer research and treatment 2026 Significance 5/10 Modified Viscoelastic Tests Show Promise for Rapid DOAC Detection at Point of Care Seminars in thrombosis and hemostasis 2026 Significance 6/10 Portable Biosensor Combines Two Thalassemia Screening Assays with 90% Concordance to Gold Standard Current molecular medicine 2026 Significance 6/10 Quantitative hepatitis B surface antigen assays show troubling inter-method variability Clinical chemistry 2026 Significance 7/10 New insights into the Epstein-Barr virus link to systemic lupus erythematosus Clinical chemistry 2026 Significance 5/10 SPARK-seq could transform clinical laboratory diagnostics beyond traditional affinity assays Clinical chemistry 2026 Significance 6/10 Companion Diagnostics Cut Oncology Drug Development Time by Nearly a Year, FDA Analysis Shows Therapeutic innovation & regulatory science 2026 Landmark-class Review: Wastewater Surveillance Methods for SARS-CoV-2 Variant Tracking and Beyond Journal of environmental management 2026 Significance 5/10 CXCL1 qPCR Assay Validated as Potential Companion Diagnostic for Bladder Cancer Immunotherapy Experimental and molecular pathology 2026 Significance 6/10 Six-Biomarker Panel Predicts Lung Cancer Relapse After Curative Radiotherapy with AUC of 0.86 Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2026 Significance 6/10 DYNAMIC: Open-Source Digital Twin of TaqMan PCR Enables In Silico Assay Optimisation Analytical chemistry 2026 Significance 6/10 Tiered Genomic Testing Achieves 48% Diagnostic Yield in 3,353 Chinese Children with Hearing Loss EBioMedicine 2026 Significance 7/10 AML with KMT2A-PTD frequently mimics myelodysplasia-related disease Journal of clinical pathology 2026 Significance 6/10 POLARIS AI Classifier Reliably Triages Colorectal Polyps, Validated on 10,000+ Slides EClinicalMedicine 2026 Landmark-class CRISPR-Cas and Isothermal Amplification Platforms Advance Toward Field-Deployable Pathogen Diagnostics Talanta 2026 Significance 5/10 ctDNA in NSCLC: Review Maps Current Evidence for MRD Detection and Treatment Monitoring BMJ oncology 2026 Significance 5/10 Full DPYD sequencing catches 26% more clinically relevant variants than targeted genotyping Clinical chemistry 2026 Landmark-class Co-occurring TERTp and TP53 mutations predict worse survival in bladder cancer Frontiers in immunology 2026 Significance 6/10 mNGS and GeneXpert Crack a Complex Case of Infantile Endobronchial Tuberculosis Frontiers in pediatrics 2026 Significance 3/10 100% of journal submissions contain gene/variant nomenclature errors Clinical chemistry 2026 Significance 7/10 CRISPR1 System Linked to Virulence and Resistance in Dominant Neonatal GBS Lineage Frontiers in cellular and infection microbiology 2026 Significance 5/10 Endogenous lithium levels explored as potential link to Alzheimer disease Clinical chemistry 2026 Significance 4/10 Commentary on unexplained salicylate elevation · lessons for the clinical lab Clinical chemistry 2026 Significance 3/10 Unexpected salicylate elevation in a patient denying aspirin use Clinical chemistry 2026 Significance 3/10 Autoimmune conditions in CMML patients linked to reduced leukaemic transformation risk Journal of clinical pathology 2026 Significance 6/10 Kinetic Model Offers Rational Design Framework for Amplification-Free CRISPR Diagnostics bioRxiv : the preprint server for biology 2026 Significance 5/10 Pre-Existing HIV Resistance Mutations Do Not Compromise Dolutegravir Efficacy in NGS Study The Journal of antimicrobial chemotherapy 2026 Significance 6/10 Whole-genome sequencing links microglandular adenosis to genomic instability in triple-negative breast cancer Journal of clinical pathology 2026 Significance 5/10 Italian Multicentre Study Tackles MRD Harmonisation in Myeloma Using NGF and NGS Cancer medicine 2026 Significance 7/10 Self-Attention Network Achieves Over 90% Cancer Classification Accuracy From Panel Sequencing Data Briefings in bioinformatics 2026 Significance 5/10 AI in Neuropathology: From Methylation Classifiers to Intraoperative Raman Histology European journal of neurology 2026 Significance 6/10 Companion Diagnostics in Oncology: Comprehensive Review of Platforms, Challenges, and Future Directions MedComm 2026 Significance 5/10 Liquid Biopsy for Early GI Cancer Detection: Multi-Analyte Platforms Near Clinical Translation Clinical and translational medicine 2026 Significance 7/10 Liquid Biopsy in Non-Metastatic Prostate Cancer: ctDNA Outperforms CTCs for Risk Stratification Cancers 2026 Significance 6/10 Molecular Screening Tools for Colorectal Cancer: From Tissue Mutations to Multi-Omic Liquid Biopsy International journal of molecular sciences 2026 Significance 5/10 Deep Learning Triage Cuts Breast Biopsy Turnaround by 38% in Simulation Clinical breast cancer 2026 Significance 5/10 AI-Powered Computational Pathology Enters the Companion Diagnostic Arena The Journal of pathology 2026 Landmark-class Digital PCR Outperforms Conventional Methods for ctDNA-Based MRD Tracking in Colorectal Liver Metastases Diagnostics (Basel, Switzerland) 2026 Significance 6/10 Review: Molecular Pathology Platforms Converge Toward Integrative Multi-Omics Diagnostics Cureus 2026 Significance 4/10 Hybrid Imaging-Molecular Surveillance Proposed for Post-Resection Cholangiocarcinoma Monitoring Cureus 2026 Significance 5/10 Multiplex CSF PCR Co-Detects HSV-1 in Pneumococcal Meningitis: Interpreting Molecular Results Cautiously Cureus 2026 Significance 3/10 Two-nodule hepatocellular carcinoma without satellites has outcomes similar to solitary HCC Journal of clinical pathology 2026 Significance 6/10 Nipah Virus Diagnostics Advance with Rapid Molecular Tests and Field-Deployable Tools Cureus 2026 Significance 4/10 Double-Hit Myeloma with 1q21+ and t(4;14): Triple-Agent Induction Improves MRD Negativity Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 2026 Significance 5/10 Exosomes in Prostate Cancer: Dual Role as Tumour Promoters and Diagnostic Biomarkers Frontiers in immunology 2026 Significance 4/10 CSF proteomics identifies candidate biomarkers for distinguishing meningitis types Infection and drug resistance 2026 Significance 5/10 Blinatumomab Shows Strong Short-Term Efficacy in Paediatric Relapsed/Refractory B-ALL Zhongguo shi yan xue ye xue za zhi 2026 Significance 5/10 Precision Psychiatry Tools Move Toward Primary Care: RNA Biomarkers, Pharmacogenomics, and Digital Phenotyping Therapeutische Umschau. Revue therapeutique 2026 Significance 5/10 Mendelian Randomisation Identifies 24 Immune Cell Phenotypes Causally Linked to Lupus Clinical, cosmetic and investigational dermatology 2026 Significance 4/10 Nomogram Predicts Prolonged Hospitalisation After Gastrointestinal Perforation Surgery International journal of general medicine 2026 Significance 3/10 Five-Year UTI Pathogen Surveillance in Suzhou Reveals Alarming Carbapenem Resistance in K. pneumoniae Infection and drug resistance 2026 Significance 5/10 Metagenomic NGS Outperforms Standard PCR for Atypical HSV-2 Encephalitis Diagnosis Infection and drug resistance 2026 Significance 5/10 Presepsin shows promise as neurological prognostic marker after cardiac arrest Journal of inflammation research 2026 Significance 4/10 EU Notified Body Perspective on MDR and IVDR Conformity Assessment Journal of market access & health policy 2026 Significance 5/10 Biomarker-First Drug Development Strategy Demonstrated for IgA-Driven Autoimmune Diseases Cambridge prisms. Precision medicine 2025 Significance 5/10