Archive

Novel HLA-A*32:202 Allele Identified by NGS and Nanopore Sequencing HLA 2026 Significance 2/10 AI-Powered Urine Test Reduces Unnecessary Prostate Biopsies by Up to 23% Journal of extracellular vesicles 2026 Significance 7/10 Nine RNA-binding proteins form prognostic model for breast cancer survival International journal of immunopathology and pharmacology 2026 Significance 5/10 Keratin 7 staining reveals disease progression markers in fatty liver disease biopsies Journal of clinical pathology 2026 Significance 6/10 AI foundation models extract quantitative MRI biomarkers for knee osteoarthritis triage NPJ digital medicine 2026 Significance 7/10 Donor age and sex shape MSC secretome signalling · a framework for potency testing Stem cell research & therapy 2026 Significance 5/10 Proenkephalin predicts worsening renal function in sepsis patients Critical care (London, England) 2026 Significance 7/10 Occupational Alcohol Exposure Causes False-Positive EtG Immunoassay Results via Cross-Reacting Glucuronide Homologues Drug testing and analysis 2026 Significance 7/10 Genomic Analysis Maps Species-Specific Polymyxin Heteroresistance in E. coli and K. pneumoniae Annals of clinical microbiology and antimicrobials 2026 Significance 6/10 Liquid Biopsy Workflow Enables Single-Cell Telomere Profiling of Myeloma CTCs from Blood BioTechniques 2026 Significance 7/10 CRISPR/Cas12a Biosensor Detects Cardiac miRNA-133a at Femtomolar Sensitivity Analytical chemistry 2026 Significance 5/10 Rb Immunohistochemistry Detects CDK4/6 Inhibitor Resistance Missed by NGS in Metastatic Breast Cancer Breast cancer research and treatment 2026 Significance 7/10 Explainable AI in Oncology: Methods to Open the Black Box Technology in cancer research & treatment 2026 Significance 5/10 Phage-Derived Binding Protein Enables Rapid, Culture-Free Detection of A. baumannii Analytical chemistry 2026 Significance 6/10 European Physicians Prioritise Rapid Fever Tests for Immunocompromised Patients and Unclear Presentations BMJ open 2026 Significance 5/10 Same-Day Hepatitis C Test-and-Treat Model Trialled Using Antibody-Only Screening in Three Countries BMJ open 2026 Significance 6/10 Pleural Fluid Biomarkers Show Promise for Diagnosing Malignant Effusions and Guiding Lung Cancer Therapy Current opinion in pulmonary medicine 2026 Significance 6/10 Ceftobiprole susceptibility testing: MIC strips reliable, disk diffusion depends on breakpoints Journal of clinical microbiology 2026 Significance 7/10 Plasma Metabolomics Classifier Detects Glioma via Seven-Metabolite Liquid Biopsy Panel Research (Washington, D.C.) 2026 Significance 7/10 CRISPR-Magnetic Microbots Enable Liquid Biopsy Cancer Subtyping via Extracellular Vesicles Analytical chemistry 2026 Significance 6/10 Manganese-Powered Cas12a Enables Amplification-Free RNA Detection at Femtomolar Sensitivity Analytical chemistry 2026 Landmark-class CRISPR/Cas13a Assay Detects Salmonella in Under 60 Minutes Across Large Clinical Cohorts PLoS neglected tropical diseases 2026 Significance 7/10 One-Pot CRISPR/Cas12a Assay With Ultrashort HDA Detects Respiratory Pathogens at Attomolar Levels Analytical chemistry 2026 Significance 7/10 Genetic Testing Reshapes the Diagnostic Workup for Childhood Nystagmus International ophthalmology clinics 2026 Significance 3/10 50-Gene NGS Panel Achieves 15% Diagnostic Yield for Hereditary Breast and Ovarian Cancer Familial cancer 2026 Significance 6/10 Melanomas in Blue Nevi Lack TERT Promoter Mutations and Carry Uniformly Low Tumour Mutational Burden Virchows Archiv : an international journal of pathology 2026 Significance 6/10 Landscape Analysis of 14 Digital Pathology Platforms Offers Selection Guide for Labs Virchows Archiv : an international journal of pathology 2026 Significance 7/10 Deep Learning System Diagnoses and Predicts Recurrence of Jaw Tumours Scientific reports 2026 Significance 4/10 Ultra-Sensitive ctDNA Assay Predicts Treatment Response 65 Days Before Imaging in Esophagogastric Cancer Scientific reports 2026 Significance 7/10 Mitochondrial Lipidomics Reveals Arachidonic Acid Deficiency as Targetable Feature in Schizophrenia Journal of advanced research 2026 Significance 4/10 Pan-Cancer Lymph Node AI Achieves 100% Sensitivity With Built-In Uncertainty Safety Net NPJ digital medicine 2026 Landmark-class Six-Gene ddPCR Panel Achieves 100% Sensitivity for Thyroid Cancer Detection in FNA Specimens Thyroid research 2026 Landmark-class Global Interlaboratory Study Exposes Significant Variability in Myositis Autoantibody Testing Journal of autoimmunity 2026 Landmark-class Nanopore Full rRNA Operon Sequencing Improves Fungal Identification in Ocular Infections PeerJ 2026 Significance 6/10 Lancet Microbe Review Maps the Expanding Toolkit for Isoniazid-Resistant TB Diagnostics The Lancet. Microbe 2026 Significance 7/10 AI-Based Pathologic Response Assessment in Lung Cancer After Neoadjuvant Therapy BMC cancer 2026 Significance 5/10 Discarded Malaria Rapid Tests Repurposed for Arbovirus Surveillance in Haiti PLoS neglected tropical diseases 2026 Significance 6/10 ctDNA Misses Lung and Surgical Bed Recurrences After Pancreatic Cancer Resection Abdominal radiology (New York) 2026 Landmark-class Irregular borders in fibroadenomas are common and should not be confused with phyllodes tumours Journal of clinical pathology 2026 Significance 6/10 Comprehensive review of metrological traceability tools for urine albumin standardisation Clinical chemistry 2026 Significance 7/10 CRISPR-based lipid lowering redefines laboratory medicine's role in gene editing era Clinical chemistry 2026 Significance 7/10 NxTAG Respiratory Pathogen Panel v2 Demonstrates High Accuracy Across Five US Clinical Sites Journal of clinical microbiology 2026 Significance 7/10 LIP-MS Molecular Fishing Identifies Therapeutic Targets for a Traditional Chinese Medicine in Rheumatoid Arthritis Journal of pharmaceutical and biomedical analysis 2026 Significance 3/10 Intraoperative MRI Volumetrics Predict Survival in Lower-Grade Glioma, Especially IDH-Mutant Tumours Journal of neuro-oncology 2026 Significance 5/10 Collaborative Framework Proposed to Streamline LDT Validation Across US Hospital Labs Journal of clinical microbiology 2026 Significance 7/10 CRISPR-Based Point-of-Care Tests Push Toward Practical H. pylori Screening ACS sensors 2026 Significance 5/10 Rapid Diagnostics and Opportunistic Infections Drive Mortality in Advanced HIV Cohort in Brazil Revista panamericana de salud publica = Pan American journal of public health 2026 Significance 6/10 AI Model Predicts Druggable Mutation Probability Before Genomic Profiling in Lung Cancer JCO clinical cancer informatics 2026 Significance 7/10 AI and Molecular Biomarkers Converge to Reshape Lung Cancer Diagnostics Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2026 Significance 5/10 Tumour-Informed Copy Number Analysis Detects ctDNA Down to 0.2% Tumour Fraction EMBO molecular medicine 2026 Significance 7/10 ctDNA Emerges as Powerful Non-Invasive Biomarker Across All Stages of Bladder Cancer European urology oncology 2026 Significance 7/10 Updated CLSI guidance brings carbapenemase testing back to the clinical lab Journal of clinical microbiology 2026 Landmark-class Genomic epidemiology reveals complex VRE dynamics behind Germany's vanB surge and decline Journal of clinical microbiology 2026 Significance 6/10 Non-fumigatus Aspergillus species cause treatable lung disease but current diagnostics miss most cases Journal of clinical microbiology 2026 Significance 7/10 In memoriam: Davise Honig Larone, pioneering clinical mycologist Journal of clinical microbiology 2026 Significance 1/10 MALDI-TOF MS and PCR Panel Enable Rapid NTM Identification Directly from Blood Culture Broth Journal of microbiological methods 2026 Significance 7/10 Real-World Adjuvant Therapy Patterns After Chemoimmunotherapy in Early Triple-Negative Breast Cancer Breast cancer research and treatment 2026 Significance 5/10 Modified Viscoelastic Tests Show Promise for Rapid DOAC Detection at Point of Care Seminars in thrombosis and hemostasis 2026 Significance 6/10 Portable Biosensor Combines Two Thalassemia Screening Assays with 90% Concordance to Gold Standard Current molecular medicine 2026 Significance 6/10 Quantitative hepatitis B surface antigen assays show troubling inter-method variability Clinical chemistry 2026 Significance 7/10 New insights into the Epstein-Barr virus link to systemic lupus erythematosus Clinical chemistry 2026 Significance 5/10 SPARK-seq could transform clinical laboratory diagnostics beyond traditional affinity assays Clinical chemistry 2026 Significance 6/10 Companion Diagnostics Cut Oncology Drug Development Time by Nearly a Year, FDA Analysis Shows Therapeutic innovation & regulatory science 2026 Landmark-class Review: Wastewater Surveillance Methods for SARS-CoV-2 Variant Tracking and Beyond Journal of environmental management 2026 Significance 5/10 CXCL1 qPCR Assay Validated as Potential Companion Diagnostic for Bladder Cancer Immunotherapy Experimental and molecular pathology 2026 Significance 6/10 Six-Biomarker Panel Predicts Lung Cancer Relapse After Curative Radiotherapy with AUC of 0.86 Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2026 Significance 6/10 DYNAMIC: Open-Source Digital Twin of TaqMan PCR Enables In Silico Assay Optimisation Analytical chemistry 2026 Significance 6/10 Tiered Genomic Testing Achieves 48% Diagnostic Yield in 3,353 Chinese Children with Hearing Loss EBioMedicine 2026 Significance 7/10 AML with KMT2A-PTD frequently mimics myelodysplasia-related disease Journal of clinical pathology 2026 Significance 6/10 POLARIS AI Classifier Reliably Triages Colorectal Polyps, Validated on 10,000+ Slides EClinicalMedicine 2026 Landmark-class CRISPR-Cas and Isothermal Amplification Platforms Advance Toward Field-Deployable Pathogen Diagnostics Talanta 2026 Significance 5/10 ctDNA in NSCLC: Review Maps Current Evidence for MRD Detection and Treatment Monitoring BMJ oncology 2026 Significance 5/10 Full DPYD sequencing catches 26% more clinically relevant variants than targeted genotyping Clinical chemistry 2026 Landmark-class Co-occurring TERTp and TP53 mutations predict worse survival in bladder cancer Frontiers in immunology 2026 Significance 6/10 mNGS and GeneXpert Crack a Complex Case of Infantile Endobronchial Tuberculosis Frontiers in pediatrics 2026 Significance 3/10 100% of journal submissions contain gene/variant nomenclature errors Clinical chemistry 2026 Significance 7/10 CRISPR1 System Linked to Virulence and Resistance in Dominant Neonatal GBS Lineage Frontiers in cellular and infection microbiology 2026 Significance 5/10 Endogenous lithium levels explored as potential link to Alzheimer disease Clinical chemistry 2026 Significance 4/10 Commentary on unexplained salicylate elevation · lessons for the clinical lab Clinical chemistry 2026 Significance 3/10 Unexpected salicylate elevation in a patient denying aspirin use Clinical chemistry 2026 Significance 3/10 Autoimmune conditions in CMML patients linked to reduced leukaemic transformation risk Journal of clinical pathology 2026 Significance 6/10 Kinetic Model Offers Rational Design Framework for Amplification-Free CRISPR Diagnostics bioRxiv : the preprint server for biology 2026 Significance 5/10 Pre-Existing HIV Resistance Mutations Do Not Compromise Dolutegravir Efficacy in NGS Study The Journal of antimicrobial chemotherapy 2026 Significance 6/10 Whole-genome sequencing links microglandular adenosis to genomic instability in triple-negative breast cancer Journal of clinical pathology 2026 Significance 5/10 Italian Multicentre Study Tackles MRD Harmonisation in Myeloma Using NGF and NGS Cancer medicine 2026 Significance 7/10 Self-Attention Network Achieves Over 90% Cancer Classification Accuracy From Panel Sequencing Data Briefings in bioinformatics 2026 Significance 5/10 AI in Neuropathology: From Methylation Classifiers to Intraoperative Raman Histology European journal of neurology 2026 Significance 6/10 Companion Diagnostics in Oncology: Comprehensive Review of Platforms, Challenges, and Future Directions MedComm 2026 Significance 5/10 Liquid Biopsy for Early GI Cancer Detection: Multi-Analyte Platforms Near Clinical Translation Clinical and translational medicine 2026 Significance 7/10 Liquid Biopsy in Non-Metastatic Prostate Cancer: ctDNA Outperforms CTCs for Risk Stratification Cancers 2026 Significance 6/10 Molecular Screening Tools for Colorectal Cancer: From Tissue Mutations to Multi-Omic Liquid Biopsy International journal of molecular sciences 2026 Significance 5/10 Deep Learning Triage Cuts Breast Biopsy Turnaround by 38% in Simulation Clinical breast cancer 2026 Significance 5/10 AI-Powered Computational Pathology Enters the Companion Diagnostic Arena The Journal of pathology 2026 Landmark-class Digital PCR Outperforms Conventional Methods for ctDNA-Based MRD Tracking in Colorectal Liver Metastases Diagnostics (Basel, Switzerland) 2026 Significance 6/10 Review: Molecular Pathology Platforms Converge Toward Integrative Multi-Omics Diagnostics Cureus 2026 Significance 4/10 Hybrid Imaging-Molecular Surveillance Proposed for Post-Resection Cholangiocarcinoma Monitoring Cureus 2026 Significance 5/10 Multiplex CSF PCR Co-Detects HSV-1 in Pneumococcal Meningitis: Interpreting Molecular Results Cautiously Cureus 2026 Significance 3/10 Two-nodule hepatocellular carcinoma without satellites has outcomes similar to solitary HCC Journal of clinical pathology 2026 Significance 6/10 Nipah Virus Diagnostics Advance with Rapid Molecular Tests and Field-Deployable Tools Cureus 2026 Significance 4/10 Double-Hit Myeloma with 1q21+ and t(4;14): Triple-Agent Induction Improves MRD Negativity Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 2026 Significance 5/10 Exosomes in Prostate Cancer: Dual Role as Tumour Promoters and Diagnostic Biomarkers Frontiers in immunology 2026 Significance 4/10 CSF proteomics identifies candidate biomarkers for distinguishing meningitis types Infection and drug resistance 2026 Significance 5/10 Blinatumomab Shows Strong Short-Term Efficacy in Paediatric Relapsed/Refractory B-ALL Zhongguo shi yan xue ye xue za zhi 2026 Significance 5/10 Precision Psychiatry Tools Move Toward Primary Care: RNA Biomarkers, Pharmacogenomics, and Digital Phenotyping Therapeutische Umschau. Revue therapeutique 2026 Significance 5/10 Mendelian Randomisation Identifies 24 Immune Cell Phenotypes Causally Linked to Lupus Clinical, cosmetic and investigational dermatology 2026 Significance 4/10 Nomogram Predicts Prolonged Hospitalisation After Gastrointestinal Perforation Surgery International journal of general medicine 2026 Significance 3/10 Five-Year UTI Pathogen Surveillance in Suzhou Reveals Alarming Carbapenem Resistance in K. pneumoniae Infection and drug resistance 2026 Significance 5/10 Metagenomic NGS Outperforms Standard PCR for Atypical HSV-2 Encephalitis Diagnosis Infection and drug resistance 2026 Significance 5/10 Presepsin shows promise as neurological prognostic marker after cardiac arrest Journal of inflammation research 2026 Significance 4/10 EU Notified Body Perspective on MDR and IVDR Conformity Assessment Journal of market access & health policy 2026 Significance 5/10 Biomarker-First Drug Development Strategy Demonstrated for IgA-Driven Autoimmune Diseases Cambridge prisms. Precision medicine 2025 Significance 5/10