Proteomic Mass Spectrometry Expands Its Role Across Pathology and Laboratory Medicine
Clinical MS has evolved from small-molecule applications (TDM, toxicology, steroids) and MALDI-TOF microbial identification toward an expanding role in peptide and protein measurement. This review surveys current analytical strategies for clinical proteomics and highlights emerging applications in clinical chemistry, microbiology, and anatomical pathology. The convergence of improved instrumentation, standardised workflows, and clinical demand is positioning protein MS as a transformative tool across multiple laboratory disciplines.
The original study
Proteomic applications in pathology and laboratory medicine: Present state and future prospects.
- Authors
- Holmes DT, Romney MG, Angel P, DeMarco ML
- Journal
- Clinical biochemistry
- Type
- Journal Article, Review
- PMID
- 32442429
Original abstract
Clinical mass spectrometry applications have traditionally focused on small molecules, particularly in the areas of therapeutic drug monitoring, toxicology, and measurement of endogenous and exogenous steroids. More recently, the use of matrix assisted laser desorption/ionization time of flight mass spectrometry for the identification of microbial pathogens has been widely implemented. Following this evolution, there has been an expanding role for the measurement of peptides and proteins in pathology and laboratory medicine. This review explores the current state of protein measurement by clinical mass spectrometry and the analytical strategies employed, as well as emerging applications in clinical chemistry, clinical microbiology and anatomical pathology.