Lab Medicine

Blood Culture Contamination Across 52 US Hospitals: Variability in Definitions Impacts Reported Rates Journal of clinical microbiology 2025 Landmark-class Antimicrobial Resistance Up to Three Times Higher in Outpatients With Cancer Than Those Without The Lancet. Oncology 2025 Landmark-class AAV9 Gene Therapy for Danon Disease Restores Cardiac LAMP2 Expression at Up to 54 Months The New England journal of medicine 2024 Landmark-class Tirzepatide Reduces Blood Volume, Inflammation and Cardiac Biomarkers in Obesity-Related HFpEF Nature medicine 2024 Landmark-class Doxycycline Post-Exposure Prophylaxis Enriches Tetracycline Resistance Genes in the Gut Resistome Nature medicine 2024 Landmark-class QuickMIC Microfluidic System Delivers Rapid AST from Positive Blood Cultures in Under 4 Hours Journal of clinical microbiology 2024 Landmark-class Neonatal Sepsis: A Lancet Seminar on Diagnosis, Treatment, and the Urgent Need for Better Diagnostics Lancet (London, England) 2024 Landmark-class IFCC Guidance on Reporting Low Cardiac Troponin Concentrations in Accelerated Diagnostic Pathways Clinical chemistry 2024 Landmark-class CLSI M100 Tables 1 Overhaul: Modernising AST Reporting for Antimicrobial Stewardship Journal of clinical microbiology 2023 Landmark-class BIOFIRE BCID2 Panel Achieves 98.9% Sensitivity for Pathogen Identification from Positive Blood Cultures Journal of clinical microbiology 2023 Landmark-class Anti-ATTR Antibody NI006 Shows Cardiac Amyloid Depletion on Imaging in Phase 1 Trial The New England journal of medicine 2023 Landmark-class Troponin I and T Show Distinct Kinetics After Coronary Bypass Surgery: Implications for Type 5 MI Diagnosis Clinical chemistry 2022 Landmark-class Cefepime/Enmetazobactam Shows Superiority Over Piperacillin/Tazobactam for Complicated UTI in Phase 3 Trial JAMA 2022 Landmark-class Fully Automated EUCAST RAST Achieves Robust Performance for Direct Blood Culture AST Including ESBL and MRSA Detection Journal of clinical microbiology 2022 Landmark-class Machine Learning Model Safely Reduces Unnecessary Blood Cultures by 30% in Emergency Departments EBioMedicine 2022 Landmark-class High-Sensitivity Troponin Assays Enable Rapid Rule-Out in Acute Coronary Syndromes Lancet (London, England) 2022 Landmark-class Acute Coronary Syndromes: High-Sensitivity Troponin Transforms Rapid Diagnosis JAMA 2022 Landmark-class JAMA Review: Nucleic Acid Amplification Tests Transform STI Diagnostics with Near-Perfect Accuracy JAMA 2022 Landmark-class High-Sensitivity Troponin T Stratifies COVID-19 Risk: A Single Value Below 6 ng/L Identifies Favorable Prognosis Clinical chemistry 2021 Landmark-class EUCAST Update: Revised S/I/R Definitions and Rapid AST from Blood Culture Bottles Journal of clinical microbiology 2021 Landmark-class EuBIVAS: High-Quality Biological Variation Data for 80 Laboratory Measurands Clinical chemistry and laboratory medicine 2021 Landmark-class Antimicrobial Use in US Nursing Homes: A National Point-Prevalence Survey JAMA 2021 Landmark-class Systematic Review Defines Optimal High-Sensitivity Troponin Strategies for Early MI Rule-Out Clinical chemistry 2021 Landmark-class Biological Variation of Cardiac Troponins: Meta-Analysis Delivers Robust Reference Change Values Clinical chemistry 2021 Landmark-class Biomarker-Based Risk Scores for Stroke and Bleeding in Atrial Fibrillation Clinical chemistry 2021 Landmark-class ESC 0/1-Hour Algorithm Leads the Field in Rapid Troponin-Based MI Rule-Out Clinical chemistry 2021 Landmark-class PCR/ESI-MS on Whole Blood Detects Bloodstream Pathogens in 25.6% of Sepsis Cases vs 14.6% by Culture Journal of clinical microbiology 2020 Landmark-class COVID-19 Coagulopathy: D-Dimer Above 2,500 ng/mL Predicts Thrombosis and Bleeding in Hospitalized Patients Blood 2020 Landmark-class BioFire FilmArray Pneumonia Panel: Multiplex Detection of Respiratory Pathogens with Semiquantitative Bacterial Results Journal of clinical microbiology 2020 Landmark-class CRP-Guided Antibiotic Duration for Gram-Negative Bacteremia: Noninferior to Fixed 14-Day Treatment JAMA 2020 Landmark-class CAMERA2 Trial: Beta-Lactam Addition to Standard MRSA Bacteremia Therapy Shows No Composite Benefit JAMA 2020 Landmark-class Blood Culture Contamination: Evidence-Based Interventions Reduce False-Positive Rates by 40-60% Clinical microbiology reviews 2019 Landmark-class Lancet Review: Drug-Resistant Tuberculosis Management Requires Rapid Genotypic and Phenotypic DST Lancet (London, England) 2019 Landmark-class International Expert Consensus Simplifies Procalcitonin-Guided Antibiotic Stewardship Algorithms Clinical chemistry and laboratory medicine 2019 Landmark-class JAMA Review: Penicillin Allergy Evaluation Is Critical for Antimicrobial Stewardship JAMA 2019 Landmark-class BNP-Based Staging System for AL Amyloidosis Validated as Alternative to NT-proBNP Blood 2018 Landmark-class Algorithm-Based Therapy for Staphylococcal Bacteremia Achieves Noninferior Outcomes with Shorter Treatment JAMA 2018 Landmark-class Comprehensive Review: MRSA Molecular Characterization, SCCmec Evolution, and Typing Methods Clinical microbiology reviews 2018 Landmark-class Procalcitonin-Guided Antibiotic Stewardship Reduces Treatment Duration in Lower Respiratory Infections Without Harm Clinical chemistry and laboratory medicine 2018 Landmark-class Infective Endocarditis Management: From Blood Cultures and Echocardiography to Emerging Imaging and Molecular Diagnostics JAMA 2018 Landmark-class Sex-Specific Troponin Thresholds: Women Need Lower Cut-Offs to Avoid Missed Myocardial Infarctions Clinical chemistry 2018 Landmark-class CLSI Best Practices for Evaluating Antimicrobial Susceptibility Tests Journal of clinical microbiology 2018 Landmark-class Accelerate Pheno System Delivers Pathogen ID in 90 Minutes and Phenotypic AST in 7 Hours from Blood Cultures Journal of clinical microbiology 2018 Landmark-class Lancet Roadmap: Fixing Pathology and Lab Medicine in Low- and Middle-Income Countries Lancet (London, England) 2018 Landmark-class Emerging Molecular Technologies for Sepsis Diagnosis: Toward the 1-to-3-Hour Ideal Test Clinical microbiology reviews 2018 Landmark-class Vi-Tetanus Toxoid Conjugate Vaccine Achieves 54.6% Efficacy Against Typhoid in Human Challenge Model Lancet (London, England) 2017 Landmark-class Serum Troponin T as a Prognostic Marker in Unstable Angina: A Historical Perspective Clinical chemistry 2017 Landmark-class Interpreting Cardiac Troponin and Natriuretic Peptides in Chronic Kidney Disease Clinical chemistry 2016 Landmark-class GDF-15: An Emerging Multi-Domain Cardiovascular Biomarker Clinical chemistry 2016 Landmark-class Conservative Oxygen Therapy Halves ICU Mortality: The Oxygen-ICU Trial JAMA 2016 Landmark-class Type 2 Myocardial Infarction and Myocardial Injury: Definitions, Diagnosis, and Clinical Implications Clinical chemistry 2016 Landmark-class Understanding Cardiac Troponin Assay Characteristics: A Guide for Laboratorians and Clinicians Clinical chemistry 2016 Landmark-class High-Sensitivity Troponin T Exhibits a Diurnal Rhythm That Troponin I Does Not Clinical chemistry 2016 Landmark-class Rapid Blood Culture Diagnostics with Direct Communication Reduce Time to Targeted Therapy: Systematic Review Clinical microbiology reviews 2016 Landmark-class Choosing Wisely Canada Publishes Seven Evidence-Based Recommendations for Point-of-Care Testing in Acute Care Clinical biochemistry 2026 Significance 7/10 Analytical Bias in Troponin Assays Affects Rule-Out Rates More Than Diagnostic Sensitivity Clinical chemistry 2025 Significance 7/10 Drug-Resistant Tuberculosis: Rapid Diagnostics and Shorter Oral Regimens Offer New Hope Clinical microbiology reviews 2025 Significance 7/10 Integrated Biomedical Innovations in HIV and STI Prevention, Diagnostics, and Service Delivery Lancet (London, England) 2025 Significance 7/10 Enteric Fever: Blood Culture Remains the Diagnostic Standard Despite Performance Limitations Lancet (London, England) 2025 Significance 7/10 Cascade Reporting of AST Results: Stewardship Tool or Surveillance Blind Spot? Journal of clinical microbiology 2025 Significance 7/10 Meta-Analysis Finds No Meaningful Difference Between hs-cTnI and hs-cTnT for Cardiovascular Risk Prediction Clinical chemistry 2025 Significance 7/10 eQUANT System Enables Same-Day Disk Diffusion AST Directly from Positive Blood Cultures Journal of clinical microbiology 2025 Significance 7/10 Presepsin Cut-Off of 713 ng/L Shows Good Accuracy for Late-Onset Sepsis in Critically Ill Neonates Clinical chemistry and laboratory medicine 2025 Significance 7/10 Structural Interventions and Rapid Diagnostics Key to Controlling Bacterial STI Epidemic EClinicalMedicine 2025 Significance 7/10 Selux Next-Generation Phenotyping System Enables Same-Day AST Directly from Positive Blood Cultures Journal of clinical microbiology 2025 Significance 7/10 Integrating High-Sensitivity Troponin into Emergency Chest Pain Evaluation BMJ (Clinical research ed.) 2025 Significance 7/10 Out-of-Hospital Cardiac Arrest in Young Adults: Troponin Central to the Diagnostic Workup JAMA 2025 Significance 7/10 Two-Transcript Signature Distinguishes SFTS Viral Infection from Bacterial Sepsis with AUC of 0.96 Journal of clinical microbiology 2024 Significance 7/10 Lancet Commission: Global Health 2050 Strategy Highlights Diagnostics as Key to Halving Premature Death Lancet (London, England) 2024 Significance 7/10 Expert Consensus on Point-of-Care Testing: Balancing Speed and Accuracy in Modern Lab Medicine Clinical chemistry and laboratory medicine 2024 Significance 7/10 Tackling AMR Requires Integrated Investment in Antibiotics, Vaccines, and Diagnostics Lancet (London, England) 2024 Significance 7/10 Molecular Susceptibility Testing for H. pylori Enables Resistance-Guided Therapy from Stool Specimens Journal of clinical microbiology 2024 Significance 7/10 Selux Next-Generation Phenotyping System Delivers Rapid AST Results in Under 6 Hours Journal of clinical microbiology 2023 Significance 7/10 Blood Culture Contamination Rate Reporting: ASM Subcommittee Recommendations for Standardized Criteria Journal of clinical microbiology 2023 Significance 7/10 IFCC LEAP Checklist Sets New Standard for Reporting Method Evaluation in Lab Medicine Annals of laboratory medicine 2023 Significance 7/10 US Clinical Breakpoint Updates: Closing the Gap Between Revision and Laboratory Implementation Journal of clinical microbiology 2023 Significance 7/10 Fungal Endocarditis: Diagnostic Strategies from Blood Culture to PET/CT Imaging Clinical microbiology reviews 2023 Significance 7/10 IFCC Consensus: Recommendations for Managing Point-of-Care Testing Outside Hospitals Clinical chemistry and laboratory medicine 2023 Significance 7/10 Broth Disk Elution Method Enables Practical Aztreonam-Ceftazidime/Avibactam Combination Testing Journal of clinical microbiology 2023 Significance 7/10 Acute Myocarditis: Troponin and Cardiac MRI as Diagnostic Cornerstones JAMA 2023 Significance 7/10 Two Days of Post-Operative Antibiotics Non-Inferior to Five Days for Complex Appendicitis Lancet (London, England) 2023 Significance 7/10 FDA-Cleared Molecular Assays Transform Laboratory Detection of Mycoplasma genitalium Journal of clinical microbiology 2023 Significance 7/10 Commercially Available Typhoid Rapid Tests Fall Short of Diagnostic Accuracy Requirements Journal of clinical microbiology 2022 Significance 7/10 Troponin T vs Troponin I in Stable Populations: Different Biology, Different Clinical Signals Clinical chemistry and laboratory medicine 2022 Significance 7/10 The Central Role of Laboratory Medicine in Public Health: From Cardiac Biomarkers to Pandemic Response Clinical chemistry and laboratory medicine 2022 Significance 7/10 Copeptin Adds No Value to High-Sensitivity Troponin at Limit-of-Detection Thresholds for NSTEMI Rule-Out Clinical biochemistry 2022 Significance 7/10 Procalcitonin in Clinical Practice: Evidence-Based Strategies for Diagnosing Infection and Guiding Antibiotics Clinical chemistry and laboratory medicine 2022 Significance 7/10 Modernising Antibiograms: Updated CLSI M39 Guidance for the Stewardship Era Journal of clinical microbiology 2022 Significance 7/10 Host Genomic Biomarkers Can Distinguish Bacterial from Non-Bacterial Infection EBioMedicine 2022 Significance 7/10 Bacteroides fragilis Group: Updated Taxonomy, Resistance Trends, and Species-Level Identification Methods Journal of clinical microbiology 2022 Significance 7/10 Machine Learning for AMR Prediction: Promise, Limitations, and the Path to Clinical Implementation Clinical microbiology reviews 2022 Significance 7/10 Cefazolin Inoculum Effect Present in Nearly One-Fifth of North American MSSA Isolates Journal of clinical microbiology 2022 Significance 7/10 Rapid Diagnostic Algorithms Using High-Sensitivity Troponin: From Evidence to Implementation Annals of clinical biochemistry 2022 Significance 7/10 H. pylori Diagnostics: Comprehensive Guide to Laboratory Methods and Resistance Detection Clinical microbiology reviews 2022 Significance 7/10 Whole-Genome Sequencing Transforms AMR Surveillance From Local Outbreaks to Global Strategy Genome medicine 2022 Significance 7/10 CLSI M100 31st Edition: New Breakpoints, Disk Diffusion from Blood Cultures, and Revised Oxacillin Thresholds Journal of clinical microbiology 2021 Significance 7/10 GenMark ePlex Gram-Negative Blood Culture Panel Demonstrates High Accuracy Across 27 Targets Journal of clinical microbiology 2021 Significance 7/10 Blood Culture Diagnostic Stewardship: Optimizing When and How to Collect Journal of clinical microbiology 2021 Significance 7/10 Cardiac Biomarkers in Pediatrics: An Undervalued Diagnostic Resource Clinical chemistry 2021 Significance 7/10 Procalcitonin Assay Harmonization Remains Incomplete Despite Growing Clinical Adoption Clinical chemistry and laboratory medicine 2021 Significance 7/10 Resolving Genotype-Phenotype Discordance in Rapid Molecular AST Panels Journal of clinical microbiology 2021 Significance 7/10 64-Biomarker Panel Reveals Distinct Inflammatory and Endothelial Pathways Driving COVID-19 Deterioration EBioMedicine 2021 Significance 7/10 Pathogenesis of Gram-Negative Bacteremia: Shared and Unique Virulence Mechanisms Across Key Species Clinical microbiology reviews 2021 Significance 7/10 Global Variation in Paediatric Beta-Lactam Dosing Threatens Pharmacodynamic Target Attainment Clinical pharmacology and therapeutics 2021 Significance 7/10 Clinical Chemistry Score Validated for AMI Rule-Out: Troponin Combined with eGFR and Glucose Clinical biochemistry 2021 Significance 7/10 High-Sensitivity Troponin Assays: Analytical Advances, Clinical Benefits, and Ongoing Challenges Clinical biochemistry 2021 Significance 7/10 Non-Reproducible Troponin Results Are More Common Than Biotin Interference and Clinically Dangerous Clinical chemistry and laboratory medicine 2021 Significance 7/10 Atrial Fibrillation Modifies the Prognostic Value of Heart Failure Biomarkers Clinical chemistry 2021 Significance 7/10 Type 2 Myocardial Infarction: Evolving Diagnostic Criteria and Risk Stratification Approaches Clinical chemistry 2021 Significance 7/10 Cardiac Troponin Testing Strategies in COVID-19: From Acute Care to Long-Term Surveillance Clinical chemistry 2021 Significance 7/10 Bridging High-Sensitivity and Point-of-Care Troponin Testing: IFCC Practice Recommendations Clinical chemistry 2021 Significance 7/10 Cardiac Biomarkers in Epidemiological Risk Prediction: From Troponin to Emerging Markers Clinical chemistry 2021 Significance 7/10 Cefiderocol Susceptibility Testing Requires Iron-Depleted Media: Practical Guidance for Laboratories Journal of clinical microbiology 2020 Significance 7/10 Biological Variation of Cardiac Troponin: Why It Matters for Diagnostic Thresholds and Serial Testing Clinical chemistry and laboratory medicine 2020 Significance 7/10 Genomic Prediction of Antimicrobial Resistance Moves Toward Clinical Laboratory Adoption Clinical chemistry 2020 Significance 7/10 Procalcitonin-Guided Stewardship Remains Effective in Patients with Impaired Kidney Function Clinical chemistry and laboratory medicine 2020 Significance 7/10 ePlex Fungal Panel Identifies 15 Fungal Pathogens from Blood Cultures with Up to 100% Sensitivity Journal of clinical microbiology 2020 Significance 7/10 Laboratory Diagnosis of Human Brucellosis: Culture, Serology, and Molecular Methods Compared Clinical microbiology reviews 2019 Significance 7/10 New VITROS High-Sensitivity Troponin I Assay Matches Established hs-cTn Platforms in Clinical Validation Clinical chemistry 2019 Significance 7/10 Navigating CLSI Breakpoint Revisions: A Practical Guide for Clinical Laboratories Journal of clinical microbiology 2019 Significance 7/10 Expert Consensus Endorses Procalcitonin for Antibiotic De-Escalation but Not as Sole Initiation Trigger Clinical chemistry and laboratory medicine 2018 Significance 7/10 Subjective Functional Assessment Unreliable Before Major Surgery; DASI Score Outperforms Lancet (London, England) 2018 Significance 7/10 Comprehensive Review of High-Sensitivity Troponin Algorithms and Accelerated Diagnostic Protocols Clinical chemistry 2018 Significance 7/10 Multiple Blood Cultures Required to Detect M. tuberculosis Bacteremia in HIV-Positive Patients Journal of clinical microbiology 2018 Significance 7/10 SensiTest Colistin Broth Microdilution Panels Validated Including mcr-1 Positive Strains Journal of clinical microbiology 2018 Significance 7/10 T2 Magnetic Resonance Outperforms Blood Culture for Monitoring Candidemia Clearance During Therapy Journal of clinical microbiology 2018 Significance 7/10 Preoperative NT-proBNP Improves Risk Prediction Beyond EuroSCORE II in Cardiac Surgery Clinical biochemistry 2018 Significance 7/10 Optimizing High-Sensitivity Cardiac Troponin Use in Suspected Myocardial Infarction Clinical biochemistry 2017 Significance 7/10 Procalcitonin Guidance Halves Antibiotic Prescriptions in Upper Respiratory Tract Infections Clinical chemistry and laboratory medicine 2017 Significance 7/10 MALDI-TOF Mass Spectrometry in Clinical Microbiology: Progress and Remaining Challenges Annals of laboratory medicine 2017 Significance 7/10 Defining the 99th Percentile for Cardiac Troponin: Methodological Challenges and the Need for Standardization Clinical chemistry and laboratory medicine 2017 Significance 7/10 MALDI-TOF MS for Positive Blood Cultures: Methods, Performance, and Clinical Impact Journal of clinical microbiology 2017 Significance 7/10 Bartonella Endocarditis: An Underdiagnosed Cause of Culture-Negative Disease Clinical microbiology reviews 2017 Significance 7/10 Laboratory Algorithm for Diagnosing Infective Endocarditis: From Blood Cultures to Molecular Testing Journal of clinical microbiology 2017 Significance 7/10 Sex-Specific Cardiac Troponin Cutoffs: Biological Rationale Versus Clinical Evidence Clinical chemistry 2017 Significance 7/10 BacT/Alert Virtuo Blood Culture System Detects Pathogens Nearly 2 Hours Faster Than Predecessor Journal of clinical microbiology 2017 Significance 7/10 Circulating microRNAs as Cardiovascular Biomarkers: From Diagnosis to Therapy Clinical chemistry and laboratory medicine 2017 Significance 7/10 Chromogenic Culture Media: A Decade of Innovation Alongside Molecular Diagnostics Clinical microbiology reviews 2017 Significance 7/10 Outlier Removal Methods Dramatically Alter Cardiac Troponin 99th Percentile Reference Limits Clinical biochemistry 2017 Significance 7/10 Troponin Levels Diverge Between Type 1 and Type 2 MI, but Mortality Runs in the Opposite Direction Clinical chemistry and laboratory medicine 2017 Significance 7/10 Biomarkers for Type 2 Diabetes: From Glycemic Indices to Cardiac Risk Stratification Clinical chemistry 2017 Significance 7/10 How Microbiology Labs Can Drive Antimicrobial Stewardship Programmes Clinical microbiology reviews 2016 Significance 7/10 Circulating Biomarkers for Risk Stratification in Stable Ischemic Heart Disease Clinical chemistry 2016 Significance 7/10 Troponin T and the Redefinition of the Myocardial Infarction Gold Standard Clinical chemistry 2016 Significance 7/10 Biomarkers for Risk Stratification and Treatment Optimization in Atrial Fibrillation Clinical chemistry 2016 Significance 7/10 Biomarker-Guided Risk Stratification in Pulmonary Embolism: Troponin, BNP and Beyond Clinical chemistry 2016 Significance 7/10 Accelerated Rule-Out and Rule-In Strategies for Myocardial Infarction in the Emergency Department Clinical chemistry 2016 Significance 7/10 Cardiac Troponin Beyond ACS: Prognostic Value Across Heart Failure, Myocarditis, and Perioperative Settings Clinical chemistry 2016 Significance 7/10 Serum Free Light Chain Testing in AL Amyloidosis: Diagnosis, Monitoring, and Prognosis Clinical chemistry and laboratory medicine 2016 Significance 7/10 Soluble ST2: An Emerging Cardiac Biomarker for Heart Failure Prognosis Clinical chemistry and laboratory medicine 2016 Significance 7/10 Four Perioperative Samples on Three Culture Media Suffice for Prosthetic Joint Infection Diagnosis Journal of clinical microbiology 2015 Significance 7/10 PiPS Trial: Bifidobacterium breve Probiotic Shows No Benefit in Very Preterm Infants Lancet (London, England) 2015 Significance 7/10 Infectious Disease Lessons From the 2024 Southern Brazil Floods: Leptospirosis, Diarrhoeal Outbreaks, and AMR Clinical microbiology reviews 2025 Significance 6/10 Pro-GRP as a Complementary Biomarker for Medullary Thyroid Carcinoma: High Specificity, Lower Sensitivity Than Calcitonin Clinical chemistry and laboratory medicine 2025 Significance 6/10 Troponin Variation Interpretation: Reference Change Values Versus Analytical Performance Specifications Clinical chemistry and laboratory medicine 2025 Significance 6/10 Achromobacter Infections: 10-Year Multicenter Analysis of 1,598 Isolates Reveals Susceptibility Patterns Journal of clinical microbiology 2025 Significance 6/10 Rapid Phenotypic AST Technologies: A Comprehensive Review of Commercial Systems for Clinical Microbiology Journal of clinical microbiology 2025 Significance 6/10 A Laboratorian's Guide to Billing and Reimbursement for Molecular Microbiology Testing Journal of clinical microbiology 2025 Significance 6/10 Updated Review of Cardiac Troponin Biology Reframes Myocardial Injury and Infarction Definitions Annals of clinical biochemistry 2025 Significance 6/10 Laboratory Diagnostics for Emergency Bleeding: A Core Panel for Rapid Clinical Decision-Making Clinical chemistry and laboratory medicine 2025 Significance 6/10 Circulating Forms of Cardiac Troponin: Implications for Immunoassay Design and Clinical Interpretation Clinical chemistry and laboratory medicine 2025 Significance 6/10 Six Inflammatory Biomarkers Compared for Infection Diagnosis in the Emergency Department Clinical biochemistry 2025 Significance 6/10 Next-Generation High-Sensitivity Cardiac Troponin Assays: Expanding the Diagnostic Window for Cardiac Injury Clinical chemistry and laboratory medicine 2025 Significance 6/10 Laboratory Reference Ranges for Transgender Patients on Gender-Affirming Hormone Therapy Clinical chemistry 2025 Significance 6/10 High-STEACS Pathway Most Efficient for Early MI Rule-Out Using Siemens hs-cTnI Clinical biochemistry 2025 Significance 6/10 Multicenter Validation of the MAGLUMI High-Sensitivity Cardiac Troponin I Assay: 99th Percentile and Sex-Specific Reference Limits Clinical chemistry and laboratory medicine 2025 Significance 6/10 EQA Beyond the Lab: How External Quality Assessment Supports Regulators, IVD Surveillance, and Pandemic Response Clinical chemistry and laboratory medicine 2025 Significance 6/10 EQA Benefits for Laboratories: From IVD Verification to Staff Competence Monitoring Clinical chemistry and laboratory medicine 2025 Significance 6/10 Integrating Cardiac Biomarkers with CT Coronary Angiography for Coronary Heart Disease Assessment Clinical biochemistry 2024 Significance 6/10 Managing Difficult-to-Treat Acinetobacter Infections: From MIC-Guided Therapy to Procalcitonin Monitoring Clinical microbiology reviews 2024 Significance 6/10 Standardised Nomenclature Proposed for Human and Animal Fungal Pathogens and Diseases Journal of clinical microbiology 2024 Significance 6/10 Blood Self-Sampling Devices Poised to Transform Laboratory Diagnostics Clinical chemistry and laboratory medicine 2024 Significance 6/10 Ethical and Regulatory Challenges of Patient Self-Testing and Near-Patient Diagnostics Clinical chemistry and laboratory medicine 2024 Significance 6/10 Cefazolin Surrogacy for Oral Cephalosporin Susceptibility in Urinary Tract Infections Journal of clinical microbiology 2024 Significance 6/10 Biofilm Antimicrobial Susceptibility Testing: Bridging the Gap Between In Vitro Models and Clinical Practice Clinical microbiology reviews 2023 Significance 6/10 Molecular Diagnostics Offer Faster H. pylori Detection and Resistance Prediction Than Culture Clinical chemistry 2023 Significance 6/10 VITEK 2 Receives FDA Clearance for Automated Omadacycline Susceptibility Testing Journal of clinical microbiology 2023 Significance 6/10 Functional Reference Limits Offer New Physiological Insights Beyond Traditional Reference Intervals Annals of laboratory medicine 2023 Significance 6/10 Rethinking Reference Methods for Antibacterial Susceptibility Testing Beyond Broth Microdilution Journal of clinical microbiology 2023 Significance 6/10 Lot-to-Lot Reagent Verification: A Critical but Under-Resourced Quality Challenge Clinical chemistry and laboratory medicine 2022 Significance 6/10 Thyroid Cancer Biomarkers: From Thyroglobulin and Calcitonin Harmonization Challenges to Emerging Diagnostics Clinical chemistry and laboratory medicine 2022 Significance 6/10 15 Years of Laboratory Test Appropriateness: CPOE-Driven Strategies That Reduced Volume and Cost Clinical chemistry and laboratory medicine 2022 Significance 6/10 Pre-Analytical Pitfalls in High-Sensitivity Troponin Testing: Storage, Interferences, and Discordant Results Clinical biochemistry 2022 Significance 6/10 Presepsin Emerges as a Promising Early Biomarker for Perinatal Sepsis Detection Clinical chemistry and laboratory medicine 2022 Significance 6/10 Susceptibility Testing for New Beta-Lactam/Beta-Lactamase Inhibitor Combinations: A Laboratory Guide Journal of clinical microbiology 2022 Significance 6/10 Scoring System for POCT Internal Quality Control Frequency in Primary Care Clinical chemistry and laboratory medicine 2022 Significance 6/10 Bacillus cereus Invasive Infections in Preterm Neonates: Underrecognised and Potentially Fatal Clinical microbiology reviews 2022 Significance 6/10 Immunohistochemistry for Infectious Disease Diagnosis: 80 Years of Evolution and 59 Detectable Pathogens Diagnostic pathology 2022 Significance 6/10 Gut Microbiome in Neurological Disorders: Diagnostic Biomarkers and Therapeutic Targets Clinical microbiology reviews 2022 Significance 6/10 VITEK 2 Meropenem-Vaborbactam Test Validated for Enterobacterales Susceptibility Testing Journal of clinical microbiology 2021 Significance 6/10 High-Sensitivity Troponin in Paediatric Populations: Promise Limited by Absent Reference Values Clinical chemistry and laboratory medicine 2021 Significance 6/10 ENOVAT Aims to Harmonise Veterinary Antimicrobial Susceptibility Testing Across Europe Journal of clinical microbiology 2021 Significance 6/10 Procalcitonin Reference Values Established for Term Pregnancy and Early Postpartum Annals of clinical biochemistry 2021 Significance 6/10 Biomarker-Guided Individualization of Antibiotic Therapy: From CRP and PCT to Pharmacometric Modeling Clinical pharmacology and therapeutics 2021 Significance 6/10 Troponin Release Mechanisms and Circulating Forms: Toward Injury-Specific Immunoassays Clinical chemistry 2021 Significance 6/10 High-Sensitivity Troponin for Population-Level Cardiovascular Risk Screening Clinical chemistry and laboratory medicine 2020 Significance 6/10 Procalcitonin as a Sepsis Biomarker in Children: Diagnosis, Prognosis, and Antibiotic Stewardship Journal of clinical microbiology 2020 Significance 6/10 Pooled Analysis Maps Laboratory Abnormalities in Pediatric COVID-19 by Severity Clinical biochemistry 2020 Significance 6/10 Digital Dispensing Enables Validated Aztreonam-Avibactam Susceptibility Testing Panels Journal of clinical microbiology 2020 Significance 6/10 Presepsin as a Diagnostic Biomarker Across Clinical Settings: From ICU Sepsis to Neonatal and Orthopedic Infections Clinical chemistry and laboratory medicine 2019 Significance 6/10 CLSI-Guided Susceptibility Testing for Nontuberculous Mycobacteria: Methods and Emerging Agents Journal of clinical microbiology 2019 Significance 6/10 Sequencing Historical Bacterial Genomes Illuminates Pathogen Evolution and AMR Origins Journal of clinical microbiology 2019 Significance 6/10 Polymyxin Susceptibility Testing Remains Technically Challenging Despite Growing Clinical Need Journal of clinical microbiology 2019 Significance 6/10 Host-Response Proteomic Biomarkers for Bacterial Respiratory Infections: Procalcitonin Leads the Field Clinical chemistry and laboratory medicine 2019 Significance 6/10 MxA Protein: A Specific Host Biomarker for Viral Infection That Complements CRP and Procalcitonin Clinical chemistry 2018 Significance 6/10 Norway's Noklus Model: 25 Years of Harmonizing Point-of-Care Testing Quality Clinical chemistry and laboratory medicine 2018 Significance 6/10 FilmArray Blood Culture ID Panel Enables Rapid Candida Species Identification from Positive Cultures Journal of clinical microbiology 2018 Significance 6/10 HbA1c and Non-Glycaemic Variables: What Lab Professionals Need to Know Journal of clinical pathology 2018 Significance 6/10 Population Structure of Canine Uropathogenic E. coli Reveals Cross-Species Strain Sharing Journal of clinical microbiology 2018 Significance 6/10 iCubate iC-GPC Assay Achieves 95.5% Agreement for Gram-Positive Bloodstream Pathogen ID Journal of clinical microbiology 2018 Significance 6/10 Heart-Type Fatty Acid Binding Protein Falls Short as a Biomarker for Acute Coronary Syndrome Clinical biochemistry 2018 Significance 6/10 Adding BNP to High-Sensitivity Troponin I Does Not Improve Detection of Exercise-Induced Ischemia Clinical biochemistry 2017 Significance 6/10 Clostridioides difficile Resistance Mechanisms and Susceptibility Testing: An Update Journal of clinical microbiology 2017 Significance 6/10 Lancet Seminar: Peptic Ulcer Disease in the Era of Declining H. pylori and Rising Drug Complexity Lancet (London, England) 2017 Significance 6/10 HEART Pathway Performs Equally Well With High-Sensitivity Troponin I as With Conventional Assays Clinical biochemistry 2017 Significance 6/10 CDC Advanced Molecular Detection Initiative Integrates Genomics Into Public Health Microbiology Journal of clinical microbiology 2016 Significance 6/10 Defining Procedural Myocardial Infarction After PCI: The Evolving Consensus Clinical chemistry 2016 Significance 6/10 Pro-Adrenomedullin and Pro-ANP Predict Quality-of-Life Decline After Community-Acquired Pneumonia Clinical chemistry and laboratory medicine 2016 Significance 6/10 Laboratory Diagnosis of Sexually Transmitted Infections: Methods, Guidelines, and Emerging Challenges Clinical chemistry 2016 Significance 6/10 Diagnosing Urinary Tract Infections in Children: Laboratory Challenges and Best Practices Journal of clinical microbiology 2016 Significance 6/10 EFLM Survey Maps ISO 15189 Accreditation Progress Across 29 European Countries Clinical chemistry and laboratory medicine 2016 Significance 6/10 Laboratory Diagnosis of Paediatric Tuberculosis Remains a Major Challenge Despite Molecular Advances Journal of clinical microbiology 2016 Significance 6/10 Optimizing Blood Culture Collection in Pediatric Patients: Volume, Timing, and Rapid Diagnostics Journal of clinical microbiology 2016 Significance 6/10 Internal Quality Control for POCT Devices: Where Is the Evidence? Annals of clinical biochemistry 2015 Significance 6/10 Global Burden of Disease 2023: Intimate Partner Violence and Sexual Violence Against Children Drive Millions of DALYs Lancet (London, England) 2025 Significance 5/10 Equipment Validation for Sterility Testing in Clinical Labs: IQ/OQ/PQ Framework Explained Journal of clinical microbiology 2025 Significance 5/10 Korean Society for Laboratory Medicine Publishes Standardized Venous Blood Collection Guidelines Annals of laboratory medicine 2025 Significance 5/10 Hospital at Home Programs Expose Gaps in Decentralized Laboratory Support Clinical biochemistry 2024 Significance 5/10 Mindray CL1200i High-Sensitivity Troponin I Assay Meets Analytical Validation Criteria Clinical chemistry and laboratory medicine 2024 Significance 5/10 Campylobacter fetus Susceptibility Patterns: Gentamicin and Meropenem Show Favourable MICs Journal of clinical microbiology 2024 Significance 5/10 ETEST Eravacycline Validated for Susceptibility Testing of Enterobacteriaceae and Enterococci Journal of clinical microbiology 2023 Significance 5/10 Temperature Challenges for i-STAT and epoc POC Blood Gas Devices in Field Settings Clinical biochemistry 2022 Significance 5/10 Redesigned ETEST Fosfomycin Strip Validated for Enterobacterales, Enterococci, and Staphylococci Journal of clinical microbiology 2022 Significance 5/10 Tutorial: Statistical Methods for Evaluating Diagnostic Test Accuracy Using Procalcitonin as an Example Clinical chemistry and laboratory medicine 2022 Significance 5/10 ETEST Plazomicin Demonstrates High Accuracy for Enterobacterales Susceptibility Testing Journal of clinical microbiology 2021 Significance 5/10 Practical Guidance for Clinical Microbiology Laboratories: Diagnosing Ocular Infections Clinical microbiology reviews 2021 Significance 5/10 Exercise-Induced Cardiac Biomarker Elevation: Physiological Response or Pathological Warning? Clinical biochemistry 2020 Significance 5/10 Red Blood Cell Distribution Width as a Prognostic Marker in Sepsis Clinical biochemistry 2020 Significance 5/10 Sphingomyelin Profiling Predicts Short-Term Outcomes in Lower Respiratory Tract Infections Clinical chemistry and laboratory medicine 2019 Significance 5/10 Salivary Biomarkers for Cardiovascular Disease: A Systematic Review of Non-Invasive Diagnostics Clinical chemistry and laboratory medicine 2018 Significance 5/10 The Early Development of Cardiac Troponin I Assays: A Historical Perspective on Biomarker Specificity Clinical chemistry 2017 Significance 5/10 Citrate Anticoagulant Improves Sensitivity of Borrelia burgdorferi Blood Culture Journal of clinical microbiology 2017 Significance 5/10 Topical Antibacterials and Antiseptics: Mechanisms, Resistance Epidemiology, and Emerging Agents Clinical microbiology reviews 2017 Significance 5/10 Galectin-3 as a Prognostic Biomarker in Acute Coronary Syndrome Clinical biochemistry 2017 Significance 5/10 EFLM Position Paper Reaffirms Importance of Blood Draw Order to Prevent Sample Contamination Clinical chemistry and laboratory medicine 2017 Significance 5/10 Chlorhexidine and Iodine Tincture Show Equivalent Blood Culture Contamination Rates Journal of clinical microbiology 2016 Significance 5/10 Tutorial: Meta-Analysis of Diagnostic Test Accuracy Studies With Bivariate Random-Effects Models Clinical chemistry and laboratory medicine 2023 Significance 4/10 Carrion's Disease: An Expanding Neglected Bartonellosis With Emerging Resistance Concerns Clinical microbiology reviews 2017 Significance 4/10 Brief Case: Diagnostic Challenge in Clinical Microbiology Journal of clinical microbiology 2024 Significance 3/10 Mixed Endocarditis Infection: A Diagnostic Microbiology Case Report Journal of clinical microbiology 2023 Significance 3/10 Brief Case: Proteus mirabilis Coraliform Lithiasis and Bacteremia in Catheterized Patient Journal of clinical microbiology 2022 Significance 3/10 Proteus mirabilis Coraliform Lithiasis and Bacteremia: A Clinical Microbiology Case Study Journal of clinical microbiology 2022 Significance 3/10