Updated Review: Nocardia Identification Transformed by MALDI-TOF and Whole Genome Sequencing
This comprehensive update on the genus Nocardia covers the significant taxonomic expansion since 2006 and evaluates modern identification methods including MALDI-TOF MS and whole genome sequencing. These technologies have dramatically improved the speed and accuracy of species-level identification, which is critical for guiding appropriate antimicrobial therapy. The review also addresses actinomycotic mycetoma, a frequently neglected disease caused by Nocardia species.
The original study
Updated Review on
- Authors
- Traxler RM, Bell ME, Lasker B, Headd B, Shieh WJ, McQuiston JR
- Journal
- Clinical microbiology reviews
- Type
- Journal Article, Review
- PMID
- 36314911
Original abstract
This review serves as an update to the previous Nocardia review by Brown-Elliott et al. published in 2006 (B. A. Brown-Elliott, J. M. Brown, P. S. Conville, and R. J. Wallace. Jr., Clin Microbiol Rev 19:259-282, 2006, https://doi.org/10.1128/CMR.19.2.259-282.2006). Included is a discussion on the taxonomic expansion of the genus, current identification methods, and the impact of new technology (including matrix-assisted laser desorption ionization-time of flight [MALDI-TOF] and whole genome sequencing) on diagnosis and treatment. Clinical manifestations, the epidemiology, and geographic distribution are briefly discussed. An additional section on actinomycotic mycetoma is added to address this often-neglected disease.