2019 ISUP Consensus Updates Prostate Cancer Grading and Embraces AI and Cribriform Reporting
The 2019 International Society of Urological Pathology consensus conference updated prostatic carcinoma grading guidelines, mandating reporting of invasive cribriform carcinoma, incorporating intraductal carcinoma into grading, and establishing rules for individual versus aggregate grading of MRI-targeted biopsies. Notably, the conference formally discussed the role of AI in Gleason grading, signalling institutional recognition of computational pathology as a clinical-grade diagnostic tool.
The original study
The 2019 International Society of Urological Pathology (ISUP) Consensus Conference on Grading of Prostatic Carcinoma.
- Authors
- van Leenders GJLH, van der Kwast TH, Grignon DJ, Evans AJ, Kristiansen G, Kweldam CF, et al.
- Journal
- The American journal of surgical pathology
- Type
- Consensus Statement, Journal Article
- PMID
- 32459716
Original abstract
Five years after the last prostatic carcinoma grading consensus conference of the International Society of Urological Pathology (ISUP), accrual of new data and modification of clinical practice require an update of current pathologic grading guidelines. This manuscript summarizes the proceedings of the ISUP consensus meeting for grading of prostatic carcinoma held in September 2019, in Nice, France. Topics brought to consensus included the following: (1) approaches to reporting of Gleason patterns 4 and 5 quantities, and minor/tertiary patterns, (2) an agreement to report the presence of invasive cribriform carcinoma, (3) an agreement to incorporate intraductal carcinoma into grading, and (4) individual versus aggregate grading of systematic and multiparametric magnetic resonance imaging-targeted biopsies. Finally, developments in the field of artificial intelligence in the grading of prostatic carcinoma and future research perspectives were discussed.