Focus areas
Focus areas on OpenBioDx: cross-cutting diagnostics themes, from precision medicine and mass spectrometry to maternal and newborn health, the global south and WHO guidance.
Precision Medicine109
Genomically guided, individualised diagnostics that match the right test and therapy to the right patient.
- AI foundation models extract quantitative MRI biomarkers for knee osteoarthritis
- Rb Immunohistochemistry Detects CDK4/6 Inhibitor Resistance Missed by NGS in Met
- AI Model Predicts Druggable Mutation Probability Before Genomic Profiling in Lun
Mass Spectrometry138
LC-MS/MS and clinical mass spectrometry across the diagnostic laboratory, from proteomics to therapeutic monitoring.
- Occupational Alcohol Exposure Causes False-Positive EtG Immunoassay Results via
- Genomic Analysis Maps Species-Specific Polymyxin Heteroresistance in E. coli and
- Plasma Metabolomics Classifier Detects Glioma via Seven-Metabolite Liquid Biopsy
Maternal & Newborn60
Prenatal, perinatal and newborn-screening diagnostics, including dried-blood-spot programmes and non-invasive prenatal testing.
- Donor age and sex shape MSC secretome signalling · a framework for potency testi
- CRISPR1 System Linked to Virulence and Resistance in Dominant Neonatal GBS Linea
- Fingerstick Hepatitis B DNA Testing with Xpert Assay Enables Decentralised Viral
Aldosterone & Adrenal9
Aldosterone, renin and adrenal testing, from primary aldosteronism to congenital adrenal hyperplasia screening.
- Lorundrostat, a Novel Aldosterone Synthase Inhibitor, Significantly Lowers Blood
- Primary Renal Ewing Sarcoma: 24-Case Series Identifies Rare EWSR1::ETV4 Fusion
- Exemestane Cross-Reacts with All Androstenedione Immunoassays, Causing Falsely E
Global South55
Diagnostics for the developing world and resource-limited settings, where access, decentralisation and cost decide impact.
- Same-Day Hepatitis C Test-and-Treat Model Trialled Using Antibody-Only Screening
- Genetic Testing Reshapes the Diagnostic Workup for Childhood Nystagmus
- Lancet Microbe Review Maps the Expanding Toolkit for Isoniazid-Resistant TB Diag
WHO Guidelines21
World Health Organization guidance, the Essential Diagnostics List and Emergency Use Listings shaping diagnostics globally.
- CRISPR-Based Point-of-Care Tests Push Toward Practical H. pylori Screening
- Three Key Practice Updates in Non-Hodgkin Lymphoma Classification for 2026
- Metagenomic Sequencing for TB Diagnosis: Promise and Practical Barriers