Focus areas
Focus areas on OpenBioDx: cross-cutting diagnostics themes, from precision medicine and mass spectrometry to maternal and newborn health, the global south and WHO guidance.
Precision Medicine136
Genomically guided, individualised diagnostics that match the right test and therapy to the right patient.
- ctDNA monitoring predicts recurrence and survival in post-surgical biliary tract
- ctDNA methylation tumor fraction evolution predicts survival in NSCLC on immunot
- ddPCR-based ctDNA monitoring detects resistance and predicts progression months
Mass Spectrometry175
LC-MS/MS and clinical mass spectrometry across the diagnostic laboratory, from proteomics to therapeutic monitoring.
- Proteomic profiling links neutrophil extracellular traps to periprosthetic joint
- Novel testosterone immunoassay improves low-concentration accuracy and clinical
- AI-driven Raman spectroscopy identifies swine bacterial pathogens in two minutes
Maternal & Newborn81
Prenatal, perinatal and newborn-screening diagnostics, including dried-blood-spot programmes and non-invasive prenatal testing.
- Review consolidates biomarker evidence and management strategies for hypertensiv
- Point-of-care glycosylated fibronectin matches sFlt-1/PlGF sensitivity for preec
- NGS achieves 69% diagnostic yield for inherited retinal dystrophies in a Northwe
Aldosterone & Adrenal13
Aldosterone, renin and adrenal testing, from primary aldosteronism to congenital adrenal hyperplasia screening.
- Second-intervention adrenal ablation or surgery restores biochemical control in
- Plasma succinate identifies SDHx deficiency and correlates with tumor burden
- ID-LC-MS/MS candidate reference procedure standardizes serum DHEAS quantificatio
Global South85
Diagnostics for the developing world and resource-limited settings, where access, decentralisation and cost decide impact.
- Divergent AST evaluation frameworks complicate breakpoint interpretation and LMI
- Machine learning-derived clinical rules guide antibiotic use for childhood diarr
- NGS achieves 69% diagnostic yield for inherited retinal dystrophies in a Northwe
WHO Guidelines23
World Health Organization guidance, the Essential Diagnostics List and Emergency Use Listings shaping diagnostics globally.
- Battery-operated point-of-care NAAT achieves 85% sensitivity for pulmonary tuber
- Adapting trauma guidelines and point-of-care diagnostics improves LMIC polytraum
- CRISPR-Based Point-of-Care Tests Push Toward Practical H. pylori Screening