Biomarkers

Whole-Genome Sequencing Finds Actionable Cancer Variants in 15% of Patients Where Standard Testing Failed Genome medicine 2023 Landmark-class RNA-Based Molecular Subtypes of Colorectal Liver Metastases Validated in Phase 3 Trial JAMA oncology 2023 Landmark-class Spatial Immune Cell Analysis in Cancer: Methods Compendium and Path to Clinical Utility The Journal of pathology 2023 Landmark-class Computational Pathology Promises Automation but Faces Major Adoption Hurdles The Journal of pathology 2023 Landmark-class Blood Neurofilament Light Predicts Progressive MS Disability After Anti-CD20 Therapy EBioMedicine 2023 Landmark-class EU IVDR Reshapes Companion Diagnostic Regulation: New Framework, New Challenges Clinical pharmacology and therapeutics 2023 Landmark-class ISO 15189 Can Satisfy IVDR Requirements for Laboratory Developed Tests, Expert Analysis Argues Clinical chemistry and laboratory medicine 2023 Landmark-class Practical Guide to Using Circulating Tumor DNA in Cancer Treatment Decisions JAMA oncology 2022 Landmark-class PET Imaging Biomarkers Predict Response to Lutetium-PSMA Therapy in Prostate Cancer The Lancet. Oncology 2022 Landmark-class Blood-based TMB fails primary endpoint as biomarker for atezolizumab in NSCLC Nature medicine 2022 Landmark-class Tertiary Lymphoid Structures Predict Immunotherapy Response in Soft-Tissue Sarcoma Nature medicine 2022 Landmark-class B-F1RST Trial: Blood-Based TMB Shows Promise but Needs Refinement for Immunotherapy Selection Nature medicine 2022 Landmark-class Atezolizumab Shows 38% Response Rate in TMB-High Tumors Across Multiple Cancer Types Cancer discovery 2022 Landmark-class Blood-Based Mass Spectrometry MRD Rivals Bone Marrow NGS in Multiple Myeloma Clinical chemistry 2021 Landmark-class What Lab Professionals Must Know About High-Sensitivity Troponin Assay Performance Clinical chemistry and laboratory medicine 2020 Landmark-class Personalised TB Risk Predictor Outperforms Crude Group-Based Approaches Nature medicine 2020 Landmark-class National Academies Workshop: Best Practices for Computational Methods in Precision Oncology JAMA oncology 2020 Landmark-class Pre-Salvage PSA Level Guides Hormone Therapy Benefit After Prostatectomy for Prostate Cancer JAMA oncology 2020 Landmark-class Folate Receptor Alpha Emerges as a Versatile Oncology Target and Predictive Biomarker Nature reviews. Clinical oncology 2020 Landmark-class Molecular Profiling for Precision Oncology: From NGS Panels to Liquid Biopsies Genome medicine 2020 Landmark-class Circulating Tumour Cells Move Beyond Counting to Multi-Omic Characterisation Clinical chemistry 2020 Landmark-class Procalcitonin Underperforms CRP and IL-6 for Pneumonia Diagnosis in Dyspnoea Patients Clinical chemistry 2019 Landmark-class Best Practices for Neoantigen Prediction in Personalised Cancer Vaccines Genome medicine 2019 Landmark-class Molecular Targets in Endometrial Cancer: From Histological to Genomic Subtyping Nature reviews. Cancer 2019 Landmark-class DNA Damage Response Biomarkers Guide Synthetic Lethal Cancer Therapy Beyond BRCA Nature reviews. Clinical oncology 2019 Landmark-class MGMT Methylation Independently Predicts Outcomes in Low-Grade Glioma Treated With Temozolomide JAMA oncology 2018 Landmark-class 28-Gene Hypoxia Signature Validated as Prognostic Biomarker in Localized Prostate Cancer EBioMedicine 2018 Landmark-class HER3 mRNA Expression Predicts Panitumumab Benefit in RAS Wild-Type Colorectal Cancer JAMA oncology 2018 Landmark-class Nucleotyping: Pan-Cancer Chromatin Biomarker Validated Across Seven Tumour Types The Lancet. Oncology 2018 Landmark-class Whole-Body MRI Detects Localized Cancers in 7% of Li-Fraumeni Patients at Baseline JAMA oncology 2017 Landmark-class Gene-Expression Signatures in Early Breast Cancer: Comparing Oncotype DX, MammaPrint, and Beyond Nature reviews. Clinical oncology 2017 Landmark-class Europe's U-PGx Consortium Launches Landmark Multi-Gene Pharmacogenomics Implementation Trial Clinical pharmacology and therapeutics 2017 Landmark-class BRCA Testing Must Expand Beyond Family History to Guide PARP Inhibitor Therapy in Ovarian Cancer Nature reviews. Clinical oncology 2016 Landmark-class Predictive Biomarkers for Checkpoint Immunotherapy: Beyond PD-L1 Alone The Lancet. Oncology 2016 Landmark-class Coronary Artery Calcium Found in One-Third of Low-Risk Women, Predicts Cardiovascular Events JAMA 2016 Landmark-class Crowdsourced DREAM Challenge Produces Superior Prognostic Model for Metastatic Prostate Cancer The Lancet. Oncology 2016 Landmark-class Ventana PD-L1 SP263 Assay Validated for NSCLC and Head and Neck Cancer Diagnostics Diagnostic pathology 2016 Landmark-class PD-L1 Testing in Lung Cancer: Multiple Assays and No Consensus Create a Biomarker Dilemma JAMA oncology 2016 Landmark-class Genetic Counselling Framework Proposed for Moderate-Penetrance Cancer Mutations Nature reviews. Clinical oncology 2016 Landmark-class AI and Machine Learning Transform Predictive Biomarker Discovery in Oncology Nature reviews. Clinical oncology 2026 Significance 7/10 Meta-Analysis of 10,000 Patients Defines Optimal Androgen Deprivation Duration for Prostate Cancer JAMA oncology 2026 Significance 7/10 From PKU to Genomics: Six Decades of Newborn Screening Evolution Clinical chemistry 2025 Significance 7/10 Biomarker-Driven Therapy in Urothelial Cancer: From FGFR3 Mutations to ctDNA Monitoring Nature reviews. Clinical oncology 2025 Significance 7/10 Metagenomic Sequencing for TB Diagnosis: Promise and Practical Barriers Journal of clinical microbiology 2025 Significance 7/10 Tumor-Infiltrating Lymphocytes Gain Ground as a Cost-Effective Breast Cancer Biomarker Human pathology 2025 Significance 7/10 Novel Methylglyoxal-Albumin Biomarker Predicts New-Onset Diabetes in Prediabetic Patients Clinical chemistry 2025 Significance 7/10 Pharmacogenomic Testing in Practice: Who, When, and Which Model to Use Clinical pharmacology and therapeutics 2025 Significance 7/10 Genomic Signatures May Enable Personalized Radiotherapy Decisions in Breast Cancer JAMA oncology 2025 Significance 7/10 Multi-Centre Italian Study Validates In-House HRD Testing as Reliable Alternative to Outsourced Assays Journal of clinical pathology 2024 Significance 7/10 Neural Antibody Testing for Autoimmune CNS Disorders: Assays, Panels, and Clinical Utility Clinical biochemistry 2024 Significance 7/10 Polygenic Risk Scores Near Clinical Use but Equity and Standardisation Lag Behind Genome medicine 2024 Significance 7/10 Anti-EGFR Antibody SCT200 Shows Promise in Refractory Colorectal Cancer; ctDNA Clearance Predicts Outcomes EBioMedicine 2024 Significance 7/10 Machine Learning for Personalized Drug Dosing: Systematic Review Finds High Potential but Poor Validation Clinical pharmacology and therapeutics 2023 Significance 7/10 International Working Group Identifies Key Pitfalls in ML-Based TIL Assessment for Breast Cancer The Journal of pathology 2023 Significance 7/10 ISUP Consensus: Bladder Cancer Molecular Subtypes Not Yet Ready for Routine Use The American journal of surgical pathology 2023 Significance 7/10 Regression Models Outperform Machine Learning for Breast Cancer Mortality Prediction BMJ (Clinical research ed.) 2023 Significance 7/10 Lipid Testing Is Evolving: Sampson-NIH Equation, ApoB, and Lp(a) Gain Ground Over Traditional LDL-C Clinical chemistry 2023 Significance 7/10 Ki67 in Breast Cancer: Pragmatic Use Despite Persistent Scoring Challenges Journal of clinical pathology 2023 Significance 7/10 Unified Framework Exposes Evidence Gaps in Neurological Protein Biomarkers EBioMedicine 2023 Significance 7/10 Removing Ethnicity from eGFR Equations: Rationale, Impact, and Remaining Questions Annals of clinical biochemistry 2023 Significance 7/10 Rethinking IVD Quality Control: A Two-Component IQC Model Tied to Clinical Performance Specs Clinical chemistry and laboratory medicine 2022 Significance 7/10 HCV Core Antigen Test Shows High Accuracy for Screening HIV-Coinfected Patients Journal of clinical microbiology 2022 Significance 7/10 USPSTF Evidence Review Finds Uncertain Benefit of Screening for Obstructive Sleep Apnea JAMA 2022 Significance 7/10 DAXX/ATRX Loss and ALT as Prognostic Biomarkers in Pancreatic Neuroendocrine Tumors Human pathology 2022 Significance 7/10 Extracellular Vesicle PD-L1 Emerges as Liquid Biopsy Biomarker for Immunotherapy Response NPJ precision oncology 2022 Significance 7/10 Comprehensive Review of Antimicrobial Susceptibility Testing Methods for Enterococci Journal of clinical microbiology 2022 Significance 7/10 CMV Cell-Mediated Immunity Assays Show Promise for Personalizing Transplant Management Journal of clinical microbiology 2022 Significance 7/10 Korean Pan-Cancer Sequencing Reveals Genomic Diversity Versus Western Cohorts Cancer discovery 2022 Significance 7/10 Combining Type I and Type II KIT Inhibitors Shows Promise in Refractory GIST, Guided by ctDNA Monitoring JAMA oncology 2021 Significance 7/10 Postoperative ctDNA Predicts Recurrence After Colorectal Cancer Liver Metastasis Resection EBioMedicine 2021 Significance 7/10 Pharmacogenomics in colorectal cancer: from DPYD testing to companion diagnostics Clinical pharmacology and therapeutics 2021 Significance 7/10 SMAD4 Alteration Plus Low MAPK9 Expression Predicts Erlotinib Benefit in Resected Pancreatic Cancer EBioMedicine 2021 Significance 7/10 Patient-Derived Models Reshape Biomarker Validation in Colorectal Cancer Cancer discovery 2021 Significance 7/10 Clinically Applicable 53-Gene Assay Predicts Survival and Chemotherapy Benefit in Gastric Cancer EBioMedicine 2020 Significance 7/10 Viral Load Testing in Transplant Medicine Hampered by Poor Assay Standardisation Journal of clinical microbiology 2020 Significance 7/10 Tumour Budding Validated as Prognostic Biomarker Across Solid Cancers Nature reviews. Clinical oncology 2020 Significance 7/10 Combining MRI and Gene-Based Hypoxia Biomarkers Improves Chemoradiotherapy Failure Prediction in Cervical Cancer EBioMedicine 2020 Significance 7/10 Polygenic Risk Scores: Promising but Not Yet Ready for Clinical Diagnostics Genome medicine 2020 Significance 7/10 Epigenetic Mutations in CREBBP and IDH2 Predict Poor Outcomes in Peripheral T-Cell Lymphoma Genome medicine 2020 Significance 7/10 ST2 Biomarker Predicts Non-Relapse Mortality After Stem Cell Transplant in Children and Adults Blood 2020 Significance 7/10 Phase 3 ANNOUNCE Trial: Olaratumab Fails to Confirm Survival Benefit in Soft Tissue Sarcoma JAMA 2020 Significance 7/10 Immunotherapy in Small-Cell Lung Cancer: Biomarker Strategies Remain Elusive Nature reviews. Clinical oncology 2020 Significance 7/10 Targeted NGS Panel Validates TMB as Predictor of Checkpoint Inhibitor Response in NSCLC The Journal of pathology 2019 Significance 7/10 Making the Case for Advanced Microbiology Tests: A Framework for Demonstrating Clinical Utility to Payers Journal of clinical microbiology 2019 Significance 7/10 Off-Label Predictive Biomarkers in GI Cancers: When Should Pathologists Say Yes? Diagnostic pathology 2019 Significance 7/10 Lung Tumor Microenvironment as a Source of Prognostic Biomarkers and Therapeutic Targets Nature reviews. Cancer 2019 Significance 7/10 Circulating Non-Coding RNAs as Cancer Biomarkers: From miRNAs to Xeno-miRNAs Nature reviews. Clinical oncology 2018 Significance 7/10 Tumor-Normal Sequencing Uncovers Secondary Germline Findings in Cancer Patients The Journal of pathology 2018 Significance 7/10 Dual PET/CT Imaging Reveals Prognostic Tumour Heterogeneity in Castration-Resistant Prostate Cancer JAMA oncology 2018 Significance 7/10 Nivolumab plus ipilimumab shows promise in specific sarcoma subtypes The Lancet. Oncology 2018 Significance 7/10 Companion diagnostics in oncology: 20 years of FDA-approved assays reviewed Clinical pharmacology and therapeutics 2017 Significance 7/10 FOXP1 Protein Expression Predicts Outcome in Rituximab-Treated Follicular Lymphoma Blood 2017 Significance 7/10 Umbrella, Basket, and Platform Trials: What Oncology Has Learned From New Biomarker-Driven Designs Clinical pharmacology and therapeutics 2017 Significance 7/10 MAF Amplification Predicts Zoledronic Acid Benefit in Breast Cancer, Potential Companion Diagnostic The Lancet. Oncology 2017 Significance 7/10 HER2-Positive Breast Cancer Lacks Validated Predictive Biomarkers Beyond HER2 Itself Nature reviews. Clinical oncology 2017 Significance 7/10 KRAS-Variant Germline Mutation Predicts Cetuximab Benefit in Head and Neck Cancer JAMA oncology 2017 Significance 7/10 Blood-Based Protein Signatures Could Enable Early Cancer Detection Nature reviews. Cancer 2017 Significance 7/10 Glasgow Blatchford Score Best at Predicting Need for Intervention in Upper GI Bleeding BMJ (Clinical research ed.) 2017 Significance 7/10 Metabolic Imaging Biomarkers Offer a Non-Invasive Window into Brain Tumor Biology Nature reviews. Clinical oncology 2016 Significance 7/10 Meta-Analysis Finds (-2)proPSA Accuracy for Prostate Cancer Remains Uncertain Clinical chemistry and laboratory medicine 2016 Significance 7/10 SPAG5 Identified as Amplified Prognostic and Chemotherapy-Predictive Biomarker in Breast Cancer The Lancet. Oncology 2016 Significance 7/10 Beyond EpCAM: Non-Epithelial Methods for Capturing Circulating Tumor Cells Clinical chemistry 2016 Significance 7/10 Autoantibody Testing in Neuromuscular Disease: Assays, Interpretation, and Clinical Impact Clinical biochemistry 2026 Significance 6/10 HOXA gene dysregulation in AML: from molecular mechanisms to menin inhibitor resistance NPJ precision oncology 2025 Significance 6/10 Vimseltinib achieves 40% response rate in tenosynovial giant cell tumour phase 3 trial Lancet (London, England) 2024 Significance 6/10 Cardiac Troponin and BNP Show Untapped Potential for Cardiovascular Risk Assessment in Pregnancy Clinical chemistry and laboratory medicine 2023 Significance 6/10 Creatinine vs. Cystatin C: A Practical Guide to Renal Biomarkers and eGFR Equations Annals of laboratory medicine 2023 Significance 6/10 How to Measure Clinical Utility of Diagnostic Tests: A Methods Review for Lab Professionals Clinical biochemistry 2023 Significance 6/10 Systematic Review Maps Prognostic Biomarker Landscape for Male Breast Cancer The Lancet. Oncology 2023 Significance 6/10 DAXX/ATRX and ALT Testing Refines Pancreatic Neuroendocrine Tumor Classification (Reprint) Human pathology 2023 Significance 6/10 Rethinking Histopathology Reporting: Focus on What Changes Patient Management Journal of clinical pathology 2022 Significance 6/10 Breast Pathology Data That Drives Treatment: A Clinical Utility Guide for Reporting Pathologists Journal of clinical pathology 2022 Significance 6/10 PAX8 and CDX2 Can Stain Positive in Breast Cancer, Risking Misdiagnosis of Tumor Origin Human pathology 2022 Significance 6/10 PD-L1-Positive Circulating Tumour Cells Emerge as Prognostic Marker in Advanced NSCLC Clinical chemistry 2021 Significance 6/10 Pembrolizumab-cetuximab combination shows 45% response rate in head and neck cancer The Lancet. Oncology 2021 Significance 6/10 Novel Biomarkers Show Promise for Monitoring Anti-TNF Therapy in IBD EBioMedicine 2021 Significance 6/10 Patient-Derived Organoids as Predictive Biomarker for Cancer Treatment Response NPJ precision oncology 2021 Significance 6/10 suPAR Combined With NT-proBNP and HEART Score Achieves 99% Negative Predictive Value in Chest Pain Clinical biochemistry 2021 Significance 6/10 Canadian Consensus Guidance on SARS-CoV-2 Serology Testing and Reporting Clinical biochemistry 2020 Significance 6/10 M2BPGi Emerges as a Versatile Serum Marker for Liver Fibrosis and HCC Risk Annals of laboratory medicine 2020 Significance 6/10 Cardiac Troponin in COVID-19: Elevated but Mostly Stable, Not Acute Coronary Syndrome Annals of clinical biochemistry 2020 Significance 6/10 suPAR Predicts Non-Cardiac Mortality After Primary PCI for STEMI Clinical biochemistry 2020 Significance 6/10 T-VEC Plus Pembrolizumab Achieves 35% Response Rate in Advanced Sarcoma JAMA oncology 2020 Significance 6/10 Pathologists Need Consensus on CD30 Detection and Reporting in Lymphoma The American journal of surgical pathology 2020 Significance 6/10 Breast Cancer Immunoassays Shift Toward Electrochemiluminescence and Automation Clinical biochemistry 2020 Significance 6/10 Hyperprogression on Immunotherapy: Identifying Patients Whose Tumours Accelerate Under Checkpoint Blockade Genome medicine 2019 Significance 6/10 Ethical Framework for Returning Epigenetic Research Results to Participants Genome medicine 2019 Significance 6/10 IMP3 Plus L1CAM Immunohistochemistry Optimises Grading of Endometrial Carcinomas Human pathology 2019 Significance 6/10 Avelumab Shows Modest Activity in Heavily Pretreated Ovarian Cancer, PD-L1 Status Explored JAMA oncology 2019 Significance 6/10 Alternative Medicine Labs Sell Unvalidated Tests With Misleading Interpretations Annals of clinical biochemistry 2019 Significance 6/10 Thyroid Laboratory Testing: A Practical Guide to Pitfalls and Clinical Interpretation Annals of laboratory medicine 2019 Significance 6/10 PACE Framework Aims to Make Preemptive Pharmacogenomics Testing Routine Clinical pharmacology and therapeutics 2018 Significance 6/10 Serum SETD7 Emerges as Novel Diagnostic Biomarker for Colorectal Cancer EBioMedicine 2018 Significance 6/10 Hair Cortisol Analysis Offers a Unique Window Into Long-Term Stress Hormones Clinical biochemistry 2018 Significance 6/10 Dasatinib Shows Activity in Imatinib-Resistant GIST; pSRC May Identify Responders JAMA oncology 2018 Significance 6/10 HCV Core Antigen Testing Matures into a Practical Alternative to RNA Detection Clinical chemistry and laboratory medicine 2018 Significance 6/10 EZH1 Mutations Help Classify Follicular Thyroid Tumours as Likely Benign Human pathology 2018 Significance 6/10 Aurora A SNP at Codon 57 Predicts Response to Alisertib in Advanced Solid Tumors EBioMedicine 2017 Significance 6/10 Ep-CAM Meta-Analysis: High Diagnostic Accuracy and Prognostic Value in Colorectal Cancer EBioMedicine 2017 Significance 6/10 Harmonising Interpretive Comments on Lab Results: Still a Long Way to Go Clinical biochemistry 2017 Significance 6/10 Returning Germline Findings from Cancer Genomics Research: Lessons from the Australian Pancreatic Cancer Genome Initiative Genome medicine 2017 Significance 6/10 c-MET Inhibition in GI Cancers: Biomarker Stratification Remains the Key Challenge Nature reviews. Clinical oncology 2017 Significance 6/10 New Antibiotics for Skin Infections Address Growing Resistance Challenges BMJ (Clinical research ed.) 2016 Significance 6/10 Bone Turnover Markers Add Prognostic Value but Preanalytic Pitfalls Persist Clinical chemistry 2016 Significance 6/10 CDK4 Inhibitor Palbociclib Shows Favorable PFS in CDK4-Amplified Liposarcoma JAMA oncology 2016 Significance 6/10 Digital E-Training Matches Live Training for Pathologists Learning Companion Diagnostic IHC Scoring Human pathology 2016 Significance 6/10 Tumor-Associated B Cells Linked to Better Survival in Primary Melanoma Human pathology 2016 Significance 6/10 Precision oncology trials need standardised biomarker reporting to unlock their data Clinical chemistry 2015 Significance 6/10 Rapid Detection of C. difficile BI/NAP1/027: Useful for Infection Control but Specificity Concerns Remain Journal of clinical microbiology 2015 Significance 6/10 18-Gene Signature Predicts Survival in Gastric Cancer via Lymphatic Endothelial Cell Pathways Diagnostic pathology 2025 Significance 5/10 Post-Neoadjuvant Breast Pathology: Current Reporting Standards and Biomarker Testing Controversies Human pathology 2025 Significance 5/10 Predictive Model Identifies Children With Vasovagal Syncope Who Will Respond to Metoprolol EBioMedicine 2025 Significance 5/10 Adenovirus Diagnostics Lag Behind: Clinical Labs Hold Untapped Research Potential Journal of clinical microbiology 2024 Significance 5/10 Urinary Angiogenin Confirmed as Reliable Biomarker for Early Bladder Cancer Detection Clinical biochemistry 2024 Significance 5/10 Macroscopic Specimen Handling in Urological Pathology Needs a Rethink Journal of clinical pathology 2024 Significance 5/10 Gut Microbiota Emerges as Diagnostic Biomarker and Therapeutic Target in Diabetes EBioMedicine 2023 Significance 5/10 Defining Clinical Utility: A Framework for Evaluating Whether Diagnostic Tests Improve Outcomes Clinical biochemistry 2023 Significance 5/10 Platelet Distribution Width Emerges as Prognostic Marker in COVID-19 Severity and Mortality Clinical chemistry and laboratory medicine 2023 Significance 5/10 How GI Pathology Reports Drive Clinical Decisions: Key Data Items That Matter Journal of clinical pathology 2022 Significance 5/10 When Pathology Data Items Matter and When They Don't: A Urological Cancer Perspective Journal of clinical pathology 2022 Significance 5/10 Platelet Function Analyser Approaching 50 Years: Strengths, Limits, and Clinical Role Clinical chemistry and laboratory medicine 2022 Significance 5/10 Risankizumab shows strong induction efficacy in Crohn's disease across two phase 3 trials Lancet (London, England) 2022 Significance 5/10 Risankizumab maintains remission in Crohn's disease in phase 3 FORTIFY trial Lancet (London, England) 2022 Significance 5/10 Prealbumin as a Nutritional Biomarker: Clinical Value and Analytical Challenges Annals of clinical biochemistry 2020 Significance 5/10 Keratin 17 Identified as Negative Prognostic Marker in High-Grade Endometrial Cancer Human pathology 2019 Significance 5/10 COPD Drug Development: New Biomarkers and Regulatory Guidance Reshape Clinical Trials Clinical pharmacology and therapeutics 2019 Significance 5/10 Machine learning in medicine: bridging AI-driven diagnostics and medical education NPJ digital medicine 2018 Significance 5/10 Brazil Charts a Path for Companion Diagnostics Amid Complex Health System Challenges The Lancet. Oncology 2016 Significance 5/10 Copeptin Reviewed as Surrogate Biomarker for Vasopressin in Pediatric Diseases Clinical chemistry and laboratory medicine 2024 Significance 4/10 MMP-7 Reviewed as Cancer Biomarker and Therapeutic Target Clinical biochemistry 2021 Significance 4/10 Upper Airway Surgery Beats Medical Management for Moderate-to-Severe Sleep Apnea in SAMS Trial JAMA 2020 Significance 4/10 Cannabidiol for Drug-Resistant Epilepsy: Early Evidence of Anticonvulsant Efficacy Clinical pharmacology and therapeutics 2016 Significance 4/10 TRPV6 Shows Sex-Dependent Prognostic Value in Esophageal Squamous Cell Carcinoma Diagnostic pathology 2016 Significance 4/10 Review highlights challenges in developing reliable gastric cancer peritoneal metastasis models EBioMedicine 2023 Significance 3/10