Lancet Series: Precision Monitoring and AI-Driven Diagnostics Are Reshaping Transplant Medicine
This Lancet Series paper reviews advances in post-transplant monitoring, from novel biomarker assays to AI-driven integration of multidimensional immune and allograft data. The authors argue that current one-size-fits-all immunosuppression regimens must give way to personalized approaches guided by emerging diagnostic modalities. The review highlights how AI algorithms can synthesize clinical, immunological, and genomic data to provide a comprehensive real-time view of transplant status, with potential extensions to xenotransplantation.
The original study
Advancing patient monitoring, diagnostics, and treatment strategies for transplant precision medicine.
- Authors
- Loupy A, Sablik M, Khush K, Reese PP
- Journal
- Lancet (London, England)
- Type
- Journal Article, Review
- PMID
- 40614744
Original abstract
Transplant medicine faces substantial challenges, as patients require lifelong immunosuppression to prevent graft rejection. Immunosuppressive regimens to date, while reasonably effective at preventing acute rejection, cause numerous health complications, compromising quality of life and patient survival. A shift towards personalised immunosuppression is needed to improve allograft health, reduce long-term adverse effects, and optimise post-transplant outcomes. This necessity has driven advancements in post-transplant monitoring and diagnostics. Innovative monitoring biomarkers and novel diagnostic modalities have been developed to advance transplant care, with many showing promise for widespread clinical implementation. With advances in artificial intelligence, algorithms have the potential to integrate multidimensional data on the immune system and allograft health, offering a comprehensive view of transplant status. This Series paper highlights the state of post-transplant immunosuppression, monitoring, and diagnostics, emphasising the transformative role of emerging innovations to personalise both allograft and patient care. Their implications could extend to xenotransplantation, further broadening their potential to redefine transplant medicine.