NEJM Review Establishes Clinical Framework for Cell-Free DNA Analysis in Cancer Treatment

This seminal NEJM review by Corcoran and Chabner outlines the clinical applications of cell-free DNA analysis across the cancer treatment continuum, from genotyping for therapy selection to monitoring treatment response and detecting resistance mechanisms. The paper helped define the field by providing a clear, clinically oriented framework for integrating cfDNA into oncology practice at a time when the technology was transitioning from research to clinical use.