ENVISION Consensus Calls for Personalized Breast Cancer Screening Based on Multi-Factor Risk Models
The European ENVISION consortium identified priority areas for personalized breast cancer early detection, including subtype-specific risk tools applicable across ancestries, intermediate biomarkers for prevention response, and hybrid implementation studies. For clinical labs, this roadmap signals growing demand for polygenic risk score testing, multi-gene panels, and liquid biopsy approaches integrated into population screening programs.
The original study
Personalized early detection and prevention of breast cancer: ENVISION consensus statement.
- Authors
- Pashayan N, Antoniou AC, Ivanus U, Esserman LJ, Easton DF, French D, et al.
- Journal
- Nature reviews. Clinical oncology
- Type
- Consensus Statement, Journal Article, Research Support, Non-U.S. Gov't, Review
- PMID
- 32555420
Original abstract
The European Collaborative on Personalized Early Detection and Prevention of Breast Cancer (ENVISION) brings together several international research consortia working on different aspects of the personalized early detection and prevention of breast cancer. In a consensus conference held in 2019, the members of this network identified research areas requiring development to enable evidence-based personalized interventions that might improve the benefits and reduce the harms of existing breast cancer screening and prevention programmes. The priority areas identified were: 1) breast cancer subtype-specific risk assessment tools applicable to women of all ancestries; 2) intermediate surrogate markers of response to preventive measures; 3) novel non-surgical preventive measures to reduce the incidence of breast cancer of poor prognosis; and 4) hybrid effectiveness-implementation research combined with modelling studies to evaluate the long-term population outcomes of risk-based early detection strategies. The implementation of such programmes would require health-care systems to be open to learning and adapting, the engagement of a diverse range of stakeholders and tailoring to societal norms and values, while also addressing the ethical and legal issues. In this Consensus Statement, we discuss the current state of breast cancer risk prediction, risk-stratified prevention and early detection strategies, and their implementation. Throughout, we highlight priorities for advancing each of these areas.