Biomarkers
Significance 7/10
Proenkephalin predicts worsening renal function in sepsis patients
A patient-level meta-analysis evaluated proenkephalin A 119-159 (penKid) as a biomarker for predicting renal deterioration and prognosis in sepsis. Based on the title and publication in Critical Care, this work aggregates individual patient data to assess the clinical utility of penKid in guiding early intervention for sepsis-associated acute kidney injury.
The original study
Clinical utility of proenkephalin A 119-159 for prediction of worsening renal function and prognosis in patients with sepsis -results of a patient-level meta-analysis.
- Authors
- Arlt B, Caironi P, Meessen J, Hartmann O, Mebazaa A, Legrand M, et al.
- Journal
- Critical care (London, England)
- PMID
- 41877211