OpenBioDx Open Diagnostics Intelligence
Focus area

Precision Medicine

Genomically guided, individualised diagnostics that match the right test and therapy to the right patient.

Latest

Liquid Biopsy

Saliva liquid biopsy captures multi-omic disease signals across oral and systemic conditions

Journal of periodontal research August 25, 2026
Significance 4/10 Liquid Biopsy

Single-cell CTC profiling captures PI3K/AKT/PTEN alterations missed by ctDNA in metastatic breast cancer

Cancer science August 25, 2026
Significance 5/10 Point of Care

CRISPR RNA engineering strategies enhance single-nucleotide discrimination in nucleic acid diagnostics

Angewandte Chemie (International ed. in English) August 14, 2026
Significance 5/10 Molecular Dx

Pharmacoexposomics framework integrates environmental metabolomics with pharmacogenomics via high-resolution mass spectrometry

Annual review of pharmacology and toxicology August 13, 2026
Significance 3/10 Liquid Biopsy

ctDNA, microbiome and inflammatory scores converge on noninvasive colorectal cancer staging

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico August 8, 2026
Significance 5/10 Molecular Dx

NGS profiling refines prognosis and identifies targetable mutations in Mexican pediatric preB-ALL

The journal of pathology. Clinical research September 1, 2026
Significance 6/10 Molecular Dx

Meta-analysis identifies eight-gene transcriptomic panel with high diagnostic accuracy for breast cancer

Cancer medicine August 1, 2026
Significance 4/10 Molecular Dx

Genomic profiling and ctDNA integration guide adaptive therapy across NSCLC stages

Cancer journal (Sudbury, Mass.) July 24, 2026
Significance 5/10 Liquid Biopsy

Circular RNAs show promise as stable liquid biopsy biomarkers for minimal residual disease

Journal of investigative medicine : the official publication of the American Federation for Clinical Research July 24, 2026
Significance 4/10 Molecular Dx

NGS hotspot panel characterizes TP53 and PIK3CA mutation frequencies in Ukrainian breast cancer

Cancer control : journal of the Moffitt Cancer Center July 24, 2026
Significance 4/10 Liquid Biopsy

Integrated biomarker testing expands lung cancer diagnostics with tissue NGS, ctDNA, and AI

Cancer journal (Sudbury, Mass.) July 24, 2026
Significance 5/10 Molecular Dx

LC-MS/MS assay accurately discriminates CYP2D6 poor metabolizers using diet-derived solanidine biomarkers

Clinical and translational science August 1, 2026
Significance 5/10

Landmark studies

Precision Medicine

99 studies
Machine Learning Meets Genomics: Convergence for Precision Oncology at the Point of Care Nature reviews. Cancer 2026 Landmark-class WHO 5th Edition: Genomics-Driven Reclassification of Myeloid Neoplasms Journal of clinical pathology 2025 Landmark-class NCI-MATCH Trial: Lessons from the Largest Tumour-Agnostic Precision Oncology Study Nature medicine 2023 Landmark-class Multi-Site Benchmarking Study Defines Analytical Performance Boundaries of Leading ctDNA Assays Nature biotechnology 2021 Landmark-class DNA Methylation Profiling Outperforms WHO Grading for Meningioma Prognosis The Lancet. Oncology 2017 Landmark-class ELN 2017 Recommendations Establish Genomic Risk Classification and MRD Framework for AML Blood 2016 Landmark-class Nature Medicine Review Positions Liquid Biopsy Across the Full Cancer Care Continuum Nature medicine 2025 Landmark-class Lung Cancer in Never-Smokers: NGS-Driven Genomic Profiling Guides Targeted Therapy JAMA 2025 Landmark-class Cancer of Unknown Primary: Molecular Profiling Transforms a Diagnostic Dead End Nature reviews. Clinical oncology 2025 Landmark-class Multiomics Tumour Profiling Guides Personalized Melanoma Treatment in Prospective TuPro Study Nature medicine 2025 Landmark-class Broad 324-Gene Panel Identifies More Matched Therapies but No Outcome Gain in Advanced Cancers Nature medicine 2025 Landmark-class Polygenic Risk Scores Poised to Reshape Precision Medicine Across Diseases Clinical chemistry 2025 Landmark-class pi-HuB: International Initiative Maps the Complete Human Proteome for Precision Medicine Nature 2024 Landmark-class BEACON CRC Biomarker Analysis Reveals Resistance Mechanisms to BRAF-Targeted Therapy via ctDNA Profiling Nature medicine 2024 Landmark-class Molecular Tumor Boards: Evolving Role in Precision Oncology and Biomarker Interpretation Nature reviews. Clinical oncology 2023 Landmark-class NTRK Fusion Testing in Thyroid Carcinoma: Expert Consensus on a Diagnostic Algorithm JAMA oncology 2023 Landmark-class Practical Guide to Using Circulating Tumor DNA in Cancer Treatment Decisions JAMA oncology 2022 Landmark-class AI Predicts Genetic Alterations from H&E Slides: Systematic Review of the Evidence The Journal of pathology 2022 Landmark-class Deep Learning in Oncology: From Digital Pathology to Multi-Omics Integration Genome medicine 2021 Landmark-class National Academies Workshop: Best Practices for Computational Methods in Precision Oncology JAMA oncology 2020 Landmark-class Molecular Profiling for Precision Oncology: From NGS Panels to Liquid Biopsies Genome medicine 2020 Landmark-class AI-Powered Digital Pathology: New Biomarker Discovery Tools for Precision Oncology Nature reviews. Clinical oncology 2019 Landmark-class WINTHER Trial Shows Combined DNA and RNA Profiling Improves Precision Oncology Matching Nature medicine 2019 Landmark-class Apolipoprotein Profiling by Mass Spectrometry Enables Precision Cardiovascular Risk Assessment Annals of clinical biochemistry 2019 Landmark-class Liquid Biopsies for Early Cancer Detection: Promise and Biological Challenges NPJ precision oncology 2017 Landmark-class
Show all 99 studies
Molecular Genetics of Gliomas Drives New Classification and Therapy Paradigm Nature reviews. Clinical oncology 2016 Landmark-class Clinical NGS in Pediatric Oncology Yields Actionable Findings in Two-Thirds of High-Risk Cases Genome medicine 2016 Landmark-class Antimicrobial Resistance Mechanisms in M. tuberculosis: A Translational Framework Clinical microbiology reviews 2026 Significance 7/10 AI and Machine Learning Transform Predictive Biomarker Discovery in Oncology Nature reviews. Clinical oncology 2026 Significance 7/10 Precision Oncology 2025 in Review: New Targets, Liquid Biopsy, and AI-Driven Insights Cancer discovery 2025 Significance 7/10 Drug-Resistant Tuberculosis: Rapid Diagnostics and Shorter Oral Regimens Offer New Hope Clinical microbiology reviews 2025 Significance 7/10 Lancet Series: Precision Monitoring and AI-Driven Diagnostics Are Reshaping Transplant Medicine Lancet (London, England) 2025 Significance 7/10 Pharmacogenomic Testing Evolves From Targeted Genotyping Toward Sequencing-Based Approaches Annals of laboratory medicine 2025 Significance 7/10 Immunotherapy Advances in Squamous Lung Cancer: Biomarker Challenges and Emerging Multi-Omics Strategies Nature reviews. Clinical oncology 2025 Significance 7/10 Precision Imaging in Oncology: Bridging the Gap Between Liquid Biopsy and Treatment Monitoring The Lancet. Oncology 2025 Significance 7/10 Patient-Derived Xenograft Models for Functional Precision Oncology in the AI Era Nature reviews. Cancer 2024 Significance 7/10 Multiplexed Tissue Imaging Poised to Transform Precision Oncology Workflows Cancer discovery 2024 Significance 7/10 Treatment Landscape for Nodal Peripheral T-Cell Lymphomas Moving Toward Biomarker-Driven Subtype-Specific Therapy Blood 2024 Significance 7/10 Capivasertib-Fulvestrant Maintains Quality of Life While Improving PFS in HR-Positive Breast Cancer The Lancet. Oncology 2024 Significance 7/10 Deep Learning in Cancer Genomics and Histopathology: Applications, Biases, and Future Workflows Genome medicine 2024 Significance 7/10 AI in Diagnostic Pathology: From Whole-Slide Imaging to FDA-Approved Clinical Tools Diagnostic pathology 2023 Significance 7/10 Machine Learning for Personalized Drug Dosing: Systematic Review Finds High Potential but Poor Validation Clinical pharmacology and therapeutics 2023 Significance 7/10 Lancet Seminar Reviews Precision Medicine Opportunities in Type 2 Diabetes Including Pharmacogenomics Lancet (London, England) 2022 Significance 7/10 Clinical Trial Design Evolves for the Precision Oncology Era Genome medicine 2022 Significance 7/10 Integrating Computational Pathology and Proteomics to Overcome Tumor Heterogeneity The Journal of pathology 2022 Significance 7/10 Korean Pan-Cancer Sequencing Reveals Genomic Diversity Versus Western Cohorts Cancer discovery 2022 Significance 7/10 Inflammation Downregulates Drug-Metabolising Enzymes: Implications for Therapeutic Drug Monitoring Clinical pharmacology and therapeutics 2021 Significance 7/10 Multimodal Data Integration for Precision Oncology: Merging Genomics, Imaging, and Clinical Data Nature reviews. Cancer 2021 Significance 7/10 PERMED-01 Trial: Extensive Molecular Profiling Finds Actionable Targets in 71% of Advanced Cancers Genome medicine 2021 Significance 7/10 SMAD4 Alteration Plus Low MAPK9 Expression Predicts Erlotinib Benefit in Resected Pancreatic Cancer EBioMedicine 2021 Significance 7/10 AI in Cancer Research: From Molecular Characterisation to Treatment Prediction Cancer discovery 2021 Significance 7/10 Biomarker-Targeted Therapy Landscape in Gastric Cancer Expands Beyond HER2, MSI and PD-L1 Nature reviews. Clinical oncology 2021 Significance 7/10 Next-Generation Sequencing in Clinical Laboratory Medicine: A Comprehensive Review Annals of laboratory medicine 2020 Significance 7/10 AI in Pathology: Current Clinical Applications and the Road to Precision Medicine Journal of clinical pathology 2020 Significance 7/10 When to Order NGS in Oncology: A Practical Guide to Precision Medicine in Clinical Practice EClinicalMedicine 2020 Significance 7/10 Molecular Diagnostics and Targeted Therapy Transform Management of Advanced Systemic Mastocytosis Blood 2020 Significance 7/10 Circulating Tumour Cells: From Metastatic Biology to Clinical Liquid Biopsy Applications Genome medicine 2020 Significance 7/10 Policy Challenges in Genomic Medicine: Reimbursement, FDA Oversight, and Gene Patent Threats Clinical chemistry 2020 Significance 7/10 MALDI Imaging Mass Spectrometry Poised to Complement IHC in Pathology Workflows Journal of clinical pathology 2019 Significance 7/10 Circulating Tumour Cells in Prostate Cancer: From Enumeration to Precision Oncology Clinical chemistry 2019 Significance 7/10 EPA and aspirin fail to reduce colorectal adenoma rates in high-risk screening patients Lancet (London, England) 2018 Significance 7/10 Point-of-Care Testing Trends: From Wearables and Microfluidics to Mass Spectrometry Clinical chemistry 2018 Significance 7/10 Precision Medicine in Biliary Tract Cancers: Actionable Mutations and Emerging Targeted Therapies Cancer discovery 2017 Significance 7/10 Blood-Based Protein Signatures Could Enable Early Cancer Detection Nature reviews. Cancer 2017 Significance 7/10 Genomic Evolution of Ductal Carcinoma In Situ: Clonal Models of Invasion The Journal of pathology 2016 Significance 7/10 Technological Considerations for Clinical Cancer Genome Profiling: From FFPE to Liquid Biopsy Genome medicine 2016 Significance 7/10 Metabolic Imaging Biomarkers Offer a Non-Invasive Window into Brain Tumor Biology Nature reviews. Clinical oncology 2016 Significance 7/10 Beyond EpCAM: Non-Epithelial Methods for Capturing Circulating Tumor Cells Clinical chemistry 2016 Significance 7/10 Eliminating MRD as a Therapeutic Endpoint Could Move CLL Treatment Toward Cure Blood 2015 Significance 7/10 Liquid Biopsy Meets Mutational Signatures: A Framework for Longitudinal Cancer Monitoring NPJ precision oncology 2026 Significance 6/10 Troponin Variation Interpretation: Reference Change Values Versus Analytical Performance Specifications Clinical chemistry and laboratory medicine 2025 Significance 6/10 VMAT2 Inhibitors in Movement Disorders: Pharmacogenetics Shapes Personalised Dosing Lancet (London, England) 2025 Significance 6/10 Emerging Molecular Targets in Breast Cancer: From NGS and Liquid Biopsy to Spatial Transcriptomics Human pathology 2025 Significance 6/10 AI and Molecular Biomarkers Drive Precision Diagnosis in Lupus Nephritis EBioMedicine 2025 Significance 6/10 Large Language Models in Precision Oncology: From Screening to Treatment Recommendation EBioMedicine 2025 Significance 6/10 Comprehensive Review Maps ctDNA Treatment Monitoring Across Lung, Colorectal, and Breast Cancer NPJ precision oncology 2025 Significance 6/10 AI-Powered Cardiovascular Risk Assessment: A Scoping Review of Machine Learning and Deep Learning Approaches EClinicalMedicine 2024 Significance 6/10 AI in Neuro-Oncology: Advances in Glioma Diagnosis, Molecular Profiling, and Precision Treatment NPJ precision oncology 2024 Significance 6/10 Circulating Tumour Cells in Breast Cancer: Current Clinical Validity and Emerging Utility Clinical chemistry 2024 Significance 6/10 Circulating Tumor Cells: From Metastatic Biology to Precision Medicine Applications Clinical chemistry 2024 Significance 6/10 Co-Occurring Genomic Alterations in Sarcomas: Secondary Hits That Drive Sarcomagenesis The Journal of pathology 2023 Significance 6/10 Genetics of Human Infertility: Expanding Demand for Reproductive Genomic Testing Science (New York, N.Y.) 2023 Significance 6/10 Thyroid Cancer Biomarkers: From Thyroglobulin and Calcitonin Harmonization Challenges to Emerging Diagnostics Clinical chemistry and laboratory medicine 2022 Significance 6/10 Rethinking Histopathology Reporting: Focus on What Changes Patient Management Journal of clinical pathology 2022 Significance 6/10 Precision Diagnostics for Advanced Cutaneous Squamous Cell Carcinoma: Liquid Biopsy and Molecular Profiling NPJ precision oncology 2022 Significance 6/10 AI-Powered Biomarker Evaluation for Personalised Treatment in Breast and Prostate Cancer Journal of clinical pathology 2021 Significance 6/10 Novel Biomarkers Show Promise for Monitoring Anti-TNF Therapy in IBD EBioMedicine 2021 Significance 6/10 Patient-Derived Organoids as Predictive Biomarker for Cancer Treatment Response NPJ precision oncology 2021 Significance 6/10 Sex and Gender Differences in Diagnostics: Implications for Laboratory Reference Ranges Lancet (London, England) 2020 Significance 6/10 NGS and Flow Cytometry Reshape Treatment Paradigms in Acute Myeloid Leukemia Clinical pharmacology and therapeutics 2020 Significance 6/10 Software-Assisted Decision Support in Digital Histopathology: From Biomarker Scoring to Multiplexed Analysis The Journal of pathology 2020 Significance 6/10 Circulating Tumour DNA in Molecular Oncology: Clinical Applications and Pre-Analytical Considerations Clinical chemistry and laboratory medicine 2020 Significance 6/10 Epilepsy Diagnostics: From EEG to Genomic Testing and Pharmacogenomics Lancet (London, England) 2019 Significance 6/10 Personalised Thrombosis Medicine: Genomics Has Not Yet Replaced Functional Coagulation Testing Blood 2016 Significance 6/10 Precision oncology trials need standardised biomarker reporting to unlock their data Clinical chemistry 2015 Significance 6/10 Mass Spectrometry as a Phenotypic Complement to Pharmacogenomics in Precision Medicine Clinical chemistry 2015 Significance 6/10 Single-Dose Lysergide (MM120) Shows Dose-Dependent Anxiety Reduction in GAD Trial JAMA 2025 Significance 5/10 Brazil Charts a Path for Companion Diagnostics Amid Complex Health System Challenges The Lancet. Oncology 2016 Significance 5/10 Anxiety Disorders: The Search for Objective Diagnostic Biomarkers Lancet (London, England) 2021 Significance 3/10